ZNF513 and PPARGC1B

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		ZNF513	PPARGC1B
Description		zinc finger protein 513	PPARG coactivator 1 beta
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytosol Mediator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleic Acid Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Protein Binding Nuclear Estrogen Receptor Binding AF-2 Domain Binding
	Biological Process	Visual Perception Positive Regulation Of Transcription By RNA Polymerase II Retina Development In Camera-type Eye	Regulation Of DNA-templated Transcription Estrogen Receptor Signaling Pathway Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Energy Homeostasis Positive Regulation Of Cold-induced Thermogenesis
Pathways			PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Drugs			Amiodarone
Diseases		Retinitis pigmentosa (RP)
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) L-selectin levels ( 25576479) Non-oily fish consumption ( 32066663)	Age spots ( 29895819) Apolipoprotein A1 levels ( 32203549) Basal cell carcinoma ( 31174203) Cutaneous malignant melanoma ( 32341527) Deep white matter hyperintensities ( 32517579) Electrocardiographic traits (multivariate) ( 32602732) Facial pigmentation measurement (polar light) ( 32835660) Facial pigmentation measurement (UV light) ( 32835660) Freckles ( 29895819) HDL cholesterol levels ( 32203549) Keratinocyte cancer (MTAG) ( 31174203) Low tan response ( 29739929) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480) Nontraumatic osteonecrosis of the femoral head ( 32701715) Obesity-related traits ( 23251661) Tanning ( 19340012) Vitiligo ( 27723757)
Interacting Genes		5 interacting genes: DNMT3A KAT5 PPARGC1B ZFP64 ZZZ3	13 interacting genes: AKT1 ESR1 ESRRG HCFC1 HNF4A PPARA SRC THRB ZBTB9 ZFP64 ZNF200 ZNF212 ZNF513
Entrez ID		130557	133522
HPRD ID		15813	10594
Ensembl ID		ENSG00000163795	ENSG00000155846
Uniprot IDs		Q8N8E2	B7ZM40 Q86YN6
PDB IDs			3SP6 6D0Y
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Response To Estradiol Regulation Of RNA Metabolic Process Protein-cysteine Methyltransferase Activity Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Histone H2AK5 Acetyltransferase Activity Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Megasporocyte Nucleus Chromosome, Centromeric Region Zinc Ion Binding Response To Ionizing Radiation DNA (cytosine-5-)-methyltransferase Activity Histone H2A Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Cellular Response To Hypoxia Cellular Response To Bisphenol A Chromatin Organization Positive Regulation Of Leukocyte Differentiation Piccolo Histone Acetyltransferase Complex AF-2 Domain Binding Autosome Genomic Imprinting Regulation Of Macromolecule Biosynthetic Process Response To Bisphenol A Regulation Of Gene Expression Intracellular Receptor Signaling Pathway Positive Regulation Of Protein Acetylation Positive Regulation Of Aggrephagy Regulation Of Primary Metabolic Process Lipid Droplet Disassembly Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Histone H4K16 Acetyltransferase Activity Unmethylated CpG Binding Positive Regulation Of Mitotic Sister Chromatid Segregation Transcription Coactivator Activity Phosphatidylethanolamine Biosynthetic Process Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Transposable Element Silencing By PiRNA-mediated DNA Methylation Response To Vitamin A Regulation Of Macromolecule Metabolic Process Regulation Of Metaphase Plate Congression Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Triglyceride Biosynthetic Process Aggrephagy Peptidyl-lysine Acetylation Protein Targeting To Vacuole Involved In Autophagy Swr1 Complex	Intracellular Receptor Signaling Pathway Nuclear Receptor Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Hormone-mediated Signaling Pathway Zinc Ion Binding Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Nuclear Steroid Receptor Activity Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleus Regulation Of Primary Metabolic Process DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Binding Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nitric-oxide Synthase Regulator Activity Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Metal Ion Binding Estrogen Response Element Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Hormone Regulation Of Fatty Acid Beta-oxidation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Small Molecule Metabolic Process Branching Involved In Mammary Gland Duct Morphogenesis Cellular Response To Hormone Stimulus Regulation Of Generation Of Precursor Metabolites And Energy Uterus Development Intracellular Signal Transduction Retinoic Acid Receptor Signaling Pathway Enzyme Binding
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