COL12A1 and WDR37

Number of citations of the paper that reports this interaction (PubMedID 34642815)
38

Data Source:
BioGRID (two hybrid)

		COL12A1	WDR37
Description		collagen type XII alpha 1 chain	WD repeat domain 37
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type XII Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Exosome Extracellular Vesicle	Nucleus Cytoplasm
	Molecular Function	Extracellular Matrix Structural Constituent Conferring Tensile Strength	Protein Binding
	Biological Process	Cell Adhesion Tissue Development Collagen Fibril Organization Endodermal Cell Differentiation	Lymphocyte Homeostasis Corpus Callosum Development
Pathways		Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Collagen chain trimerization
Drugs
Diseases
GWAS		Central corneal thickness ( 29760442 32528159) Joint mobility (Beighton score) ( 27182965) Keratoconus ( 33649486) Systemic juvenile idiopathic arthritis ( 27927641)	Chronic kidney disease ( 20383146 26831199) Estimated glomerular filtration rate ( 30604766 31015462) Glomerular filtration rate (creatinine) ( 26831199 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		4 interacting genes: DYSF HSP90AA1 MYBPC2 WDR37	6 interacting genes: COL12A1 EIF4G3 EWSR1 LARP4B MEOX2 TRIP11
Entrez ID		1303	22884
HPRD ID		00377	15668
Ensembl ID		ENSG00000111799	ENSG00000047056
Uniprot IDs		Q99715	Q9Y2I8
PDB IDs
Enriched GO Terms of Interacting Partners?		CTP Binding DATP Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Monocyte Activation Involved In Immune Response Rho GDP-dissociation Inhibitor Binding Chaperone-mediated Autophagy Sperm Mitochondrial Sheath Positive Regulation Of Cardiac Muscle Contraction Nitric-oxide Synthase Regulator Activity Inclusion Body Assembly Dendritic Growth Cone Sperm Plasma Membrane TPR Domain Binding Telomerase Holoenzyme Complex Assembly
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