COL6A2 and SLC38A3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		COL6A2	SLC38A3
Description		collagen type VI alpha 2 chain	solute carrier family 38 member 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type VI Trimer Extracellular Space Endoplasmic Reticulum Lumen Membrane Extracellular Matrix Protein-containing Complex Sarcolemma Extracellular Exosome Extracellular Vesicle	Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane
	Molecular Function	Protein Binding Collagen Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength	L-histidine Transmembrane Transporter Activity Neutral L-amino Acid:sodium Symporter Activity Amino Acid Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity L-asparagine Transmembrane Transporter Activity L-glutamine Transmembrane Transporter Activity Symporter Activity Antiporter Activity L-glutamine, Sodium:proton Antiporter Activity L-asparagine, Sodium:proton Antiporter Activity L-histidine, Sodium:proton Antiporter Activity
	Biological Process	Cell Adhesion Response To UV Response To Glucose Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Neuron Apoptotic Process	Amino Acid Transmembrane Transport Monoatomic Ion Transport Sodium Ion Transport Amino Acid Transport Asparagine Transport Glutamine Transport Female Pregnancy Glutamine Secretion L-alanine Transport Histidine Transport Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Potassium Ion Starvation Intracellular Amino Acid Homeostasis Transport Across Blood-brain Barrier L-histidine Transport L-glutamine Import Across Plasma Membrane L-histidine Import Across Plasma Membrane L-asparagine Import Across Plasma Membrane Positive Regulation Of Glutamine Transport
Pathways		Collagen degradation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions ECM proteoglycans ECM proteoglycans NCAM1 interactions Collagen chain trimerization	Amino acid transport across the plasma membrane
Drugs			Histidine Asparagine
Diseases		Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS		Appendicular lean mass ( 33097823) Central corneal thickness ( 29760442 32528159) Height ( 31562340) Intraocular pressure ( 29235454) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Body mass index ( 26426971) Conotruncal heart defects (maternal effects) ( 28468790) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sleep duration (short sleep) ( 30846698) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		8 interacting genes: ABCD3 COL6A1 COX6A2 ERG FN1 RUNX1 SIRPA SLC38A3	4 interacting genes: COL6A2 HMGN1 SETDB1 TNFSF14
Entrez ID		1292	10991
HPRD ID		02110	11980
Ensembl ID		ENSG00000142173	ENSG00000188338
Uniprot IDs		A0A384MDP3 P12110	Q99624
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Extracellular Matrix Organization Positive Regulation Of Cell Adhesion Core-binding Factor Complex Tissue Regeneration Collagen Binding Collagen Type VI Trimer Basement Membrane Endodermal Cell Differentiation Multicellular Organismal Locomotion Response To Polyamine Macromolecule Response To Activity Response To Muscle Activity Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Phytanic Acid Metabolic Process Organic Acid Transmembrane Transport Carboxylic Acid Transmembrane Transport Cellular Response To Potassium Ion Starvation Asparagine Transport Asparagine Transmembrane Transport Positive Regulation Of Glutamine Transport Glutamine Secretion L-asparagine, Sodium:proton Antiporter Activity L-asparagine Transmembrane Transporter Activity Histidine Transport L-histidine Import Across Plasma Membrane L-glutamine, Sodium:proton Antiporter Activity L-asparagine Import Across Plasma Membrane L-histidine, Sodium:proton Antiporter Activity Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Cellular Response To Interleukin-12 Cardiac Muscle Tissue Regeneration Ossification Regeneration Calcium-independent Cell-matrix Adhesion Methyl-branched Fatty Acid Metabolic Process Long-chain Fatty Acid Import Into Peroxisome L-histidine Transport Protein Binding Involved In Heterotypic Cell-cell Adhesion Response To Interleukin-12 Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Neutral L-amino Acid:sodium Symporter Activity L-glutamine Import Across Plasma Membrane L-histidine Transmembrane Transporter Activity L-histidine Transmembrane Transport Monocyte Extravasation Response To Reactive Oxygen Species Regulation Of Cell Activation Response To Bleomycin Apoptotic Nuclear Changes	Collagen Type VI Trimer Response To Radiation Response To Light Stimulus Response To UV Pyrimidine Dimer Repair Regulation Of Development, Heterochronic Pyrimidine Dimer Repair By Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair Female Germ Cell Nucleus Post-embryonic Camera-type Eye Morphogenesis Response To UV-C Post-embryonic Eye Morphogenesis T Cell Chemotaxis Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Positive Regulation Of T Cell Chemotaxis Regulation Of T Cell Chemotaxis Positive Regulation Of Myoblast Fusion Heterochromatin Organization Histone H3K9 Trimethyltransferase Activity Histone H3K9 Monomethyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K9 Methyltransferase Activity Chromatin Binding Response To UV-B Positive Regulation Of Lymphocyte Chemotaxis Regulation Of Myoblast Fusion Regulation Of Lymphocyte Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Histone H3 Methyltransferase Activity Transposable Element Silencing By Heterochromatin Formation
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