COL5A1 and LGALS3BP

Number of citations of the paper that reports this interaction (PubMedID 9501082)
41

Data Source:
HPRD (in vitro, in vivo)

		COL5A1	LGALS3BP
Description		collagen type V alpha 1 chain	galectin 3 binding protein
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type V Trimer Collagen Type XI Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix	Extracellular Region Extracellular Space Membrane Extracellular Matrix Platelet Dense Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Proteoglycan Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Scavenger Receptor Activity Protein Binding
	Biological Process	Blood Vessel Development Heart Morphogenesis Cell Adhesion Cell Migration Collagen Fibril Organization Collagen Biosynthetic Process Wound Healing, Spreading Of Epidermal Cells Tendon Development Skin Development Integrin Biosynthetic Process Eye Morphogenesis Regulation Of Cellular Component Organization Supramolecular Fiber Organization Negative Regulation Of Endodermal Cell Differentiation	Cellular Defense Response Cell Adhesion Signal Transduction Vesicle-mediated Transport
Pathways		Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization Attachment of bacteria to epithelial cells Developmental Lineage of Pancreatic Ductal Cells	Platelet degranulation
Drugs
Diseases		Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		Blood pressure ( 24954895) Central corneal thickness ( 20719862 22814818 23493294 32528159 28171582 31798171 29760442 30894546) Corneal structure ( 23291589) Crohn's disease (need for surgery) ( 23665963) Femur bone mineral density x serum urate levels interaction ( 34046847) Intraocular pressure ( 29617998) Keratoconus ( 33649486) Longevity ( 20834067) Metabolite levels ( 23823483) Phosphatidylcholine levels ( 31551469) Refractive error ( 32231278) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Blood protein levels ( 30072576)
Interacting Genes		10 interacting genes: BMP1 COL5A3 DCN LGALS3BP MAG PDGFA PDGFB SDC3 SPARC THBS1	24 interacting genes: CD14 COL5A1 COL6A1 FBXO7 FN1 GALNT6 HSP90AA1 ITGA5 ITGA6 ITGAV ITGB1 LGALS1 LGALS3 NID1 PPIC SELE SIGLEC10 SIGLEC11 SIGLEC5 SIGLEC6 SIGLEC7 SIGLEC9 WNT4 XRN1
Entrez ID		1289	3959
HPRD ID		00368	02796
Ensembl ID		ENSG00000130635	ENSG00000108679
Uniprot IDs		B2ZZ86 P20908 Q59EE7	Q08380
PDB IDs		7Y37	1BY2 6GFB
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Collagen Binding Platelet Alpha Granule Lumen Golgi Lumen Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Extracellular Matrix Binding Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Extracellular Region Extracellular Space Regulation Of Endothelial Cell Migration Negative Regulation Of Phospholipid Biosynthetic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Autophosphorylation Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Hemostasis Regulation Of Blood Coagulation Negative Regulation Of Multicellular Organismal Process Platelet-derived Growth Factor Binding Cell Surface Regulation Of Glomerular Mesangial Cell Proliferation Endoplasmic Reticulum Lumen Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Protein Autophosphorylation Proteoglycan Binding Platelet-derived Growth Factor Receptor Binding Extracellular Matrix Structural Constituent Positive Regulation Of Endothelial Cell Migration Regulation Of Phospholipid Biosynthetic Process Negative Regulation Of Platelet Activation Platelet Alpha Granule Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Regulation Of Wound Healing Regulation Of Anatomical Structure Morphogenesis Regulation Of Endothelial Cell Proliferation Growth Factor Activity Regulation Of Developmental Process Negative Regulation Of Developmental Process Regulation Of Cell Migration Regulation Of Response To Wounding Regulation Of Cell Motility Regulation Of Locomotion Response To Wounding Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Phospholipid Metabolic Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion	Cell Adhesion Sialic Acid Binding Carbohydrate Binding Wound Healing, Spreading Of Epidermal Cells Cell-matrix Adhesion Laminin Binding Integrin Complex Cell-substrate Adhesion Wound Healing, Spreading Of Cells Response To Muscle Activity Endodermal Cell Differentiation Integrin-mediated Signaling Pathway Proteoglycan Binding Regulation Of Cellular Component Organization Plasma Membrane Extracellular Matrix Cell Surface Cell Migration Integrin Binding Integrin Alpha6-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alphav-beta1 Complex Response To Activity Positive Regulation Of Cell Adhesion Cell Motility Basement Membrane Positive Regulation Of Cell Migration Regulation Of Locomotion Cell Adhesion Mediated By Integrin Regulation Of Cell Adhesion Secretory Granule Membrane Positive Regulation Of Cell Motility Calcium-independent Cell-matrix Adhesion Positive Regulation Of Locomotion Basement Membrane Organization Negative Regulation Of Apoptotic Signaling Pathway Heterotypic Cell-cell Adhesion Neuregulin Binding C-X3-C Chemokine Binding Cell-substrate Junction Assembly Cell-substrate Junction Organization Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Dendritic Cell Differentiation Signaling Receptor Activity Regulation Of Cell Migration Cell-cell Adhesion Mediated By Integrin Extracellular Exosome Endoplasmic Reticulum Lumen Extracellular Region Regulation Of Cell Motility
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?