DUSP15 and POFUT1

		DUSP15	POFUT1
Description		dual specificity phosphatase 15	protein O-fucosyltransferase 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Endoplasmic Reticulum Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity	Transferase Activity Glycosyltransferase Activity Peptide-O-fucosyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction Dephosphorylation Regulation Of Oligodendrocyte Differentiation Positive Regulation Of ERK1 And ERK2 Cascade	Angiogenesis Somitogenesis Fucose Metabolic Process Protein Glycosylation Notch Signaling Pathway Nervous System Development Heart Development Regulation Of Notch Signaling Pathway Protein O-linked Glycosylation Via Fucose
Pathways			Pre-NOTCH Processing in the Endoplasmic Reticulum
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Blood protein levels ( 30072576) Chronic obstructive pulmonary disease ( 28166215) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908)
Interacting Genes		3 interacting genes: IGF1R POFUT1 PTK7	13 interacting genes: AKT2 DEFB115 DEFB116 DLL1 DUSP15 ERGIC3 ID1 JAG1 NAP1L2 NOTCH1 PTPRA USH2A ZIC3
Entrez ID		128853	23509
HPRD ID		13252	06319
Ensembl ID		ENSG00000149599	ENSG00000101346
Uniprot IDs		Q9H1R2	Q9H488
PDB IDs		1YZ4	5UX6 5UXH
Enriched GO Terms of Interacting Partners?		Insulin-like Growth Factor Receptor Activity Protein Kinase Complex Insulin Receptor Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Insulin Binding Insulin Receptor Activity Heart Development Protein O-linked Glycosylation Via Fucose Peptide-O-fucosyltransferase Activity Axon Peptidyl-tyrosine Autophosphorylation Insulin-like Growth Factor Binding Protein Kinase Activity Cell Surface Receptor Signaling Pathway Insulin-like Growth Factor I Binding Dendritic Spine Maintenance Insulin Receptor Substrate Binding Protein Transporter Activity Lung-associated Mesenchyme Development Axon Guidance Receptor Activity Convergent Extension Fucose Metabolic Process Phosphatidylinositol 3-kinase Binding Establishment Of Epithelial Cell Apical/basal Polarity Axis Elongation Transcytosis Insulin Receptor Binding Establishment Of Planar Polarity Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Amyloid-beta Clearance Coronary Vasculature Development Cochlea Morphogenesis Establishment Of Epithelial Cell Polarity Regulation Of Signal Transduction Dendritic Spine Organization Insulin-like Growth Factor Receptor Signaling Pathway Ventricular Septum Development Positive Regulation Of Protein-containing Complex Disassembly Anatomical Structure Formation Involved In Morphogenesis Regulation Of Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Activity Neuron Projection Organization Cellular Response To Amyloid-beta Plasma Membrane Bounded Cell Projection Organization Postsynapse Organization Peptidyl-tyrosine Phosphorylation Cellular Response To Oxygen-containing Compound	Neuron Differentiation Inhibition Of Neuroepithelial Cell Differentiation Regulation Of Timing Of Cell Differentiation Regulation Of Development, Heterochronic Left/right Axis Specification Inner Ear Auditory Receptor Cell Differentiation Hair Cell Differentiation Inner Ear Receptor Cell Differentiation Epidermal Cell Differentiation Nephron Tubule Development Renal Tubule Development Neuronal Stem Cell Population Maintenance Notch Binding Mechanoreceptor Differentiation Tube Morphogenesis Stem Cell Population Maintenance Maintenance Of Cell Number Neuroepithelial Cell Differentiation Distal Tubule Development Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Compartment Pattern Specification Positive Regulation Of Notch Signaling Pathway Loop Of Henle Development Negative Regulation Of Epithelial Cell Differentiation Epithelial Cell Differentiation Regulation Of Somitogenesis Regulation Of Neuron Differentiation Heart Looping Embryonic Heart Tube Morphogenesis Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Kidney Epithelium Development Negative Regulation Of Neuron Differentiation Epithelium Development Regulation Of Inner Ear Auditory Receptor Cell Differentiation Axis Specification Regulation Of Embryonic Development Nephron Development Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Regulation Of Notch Signaling Pathway Negative Regulation Of Epidermal Cell Differentiation Regulation Of Cell Differentiation Blood Vessel Morphogenesis Notch Signaling Pathway Pulmonary Valve Morphogenesis Epithelial Tube Morphogenesis Morphogenesis Of An Epithelium Cell Differentiation Neuroendocrine Cell Differentiation
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