RNF19B and GOSR2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RNF19B	GOSR2
Description		ring finger protein 19B	golgi SNAP receptor complex member 2
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Cytolytic Granule	Golgi Membrane Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane SNARE Complex Late Endosome Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	SNARE Binding SNAP Receptor Activity Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Natural Killer Cell Mediated Cytotoxicity Protein Autoubiquitination	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Vesicle Fusion Protein Transport Vesicle-mediated Transport
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	COPII-mediated vesicle transport XBP1(S) activates chaperone genes Cargo concentration in the ER COPI-mediated anterograde transport Intra-Golgi traffic
Drugs
Diseases
GWAS		Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)	Aortic root size ( 28394258) Aortic valve area ( 33125279) Atrial fibrillation ( 29892015) Blood pressure ( 21909110) Blood urea nitrogen levels ( 31152163 29403010) Body mass index ( 26426971) Congenital heart disease (anomalies of thoracic arteries and veins) ( 33201861) Coronary artery disease ( 33020668 29212778) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Feeling guilty ( 29500382) Feeling worry ( 29500382) Hemoglobin levels ( 32327693) Idiopathic pulmonary fibrosis ( 29066090) Ischemic stroke ( 29930801) Mean arterial pressure ( 27618448) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Myocardial infarction ( 30226566) Nonsyndromic cleft lip with cleft palate ( 28232668) Pulse pressure ( 28739976 27841878 30578418) QRS duration ( 27577874 21076409 30012220) QT interval ( 29874175) Systolic blood pressure ( 30578418 27618447 28739976 27618452 28135244 21909115 27841878)
Interacting Genes		30 interacting genes: APOL3 ASGR1 CDIPT CLEC1A DHODH FDPS GIMAP5 GOSR2 ICMT MEST MS4A1 NIPAL4 PPP1CC RAP1GDS1 SACM1L SEC22A SEC23A SELENOK SLC30A3 SLC61A1 TAP1 TMEM100 TMEM120B TMEM208 TMEM31 TNF TSPAN2 UBE2D2 UBE2D3 UBE2L3	54 interacting genes: APP AQP6 ARF1 ARL13B BIK BLCAP CREB3L1 CYB561 CYBRD1 EBP ELOVL4 ELOVL5 ERGIC3 FAM174A FAM209A FATE1 GOLGA8EP GOLGA8F GPR152 GPR42 GPX8 HDAC5 HIBADH HSD17B13 IER3IP1 JAGN1 KASH5 LEUTX LIME1 LMNA MARCHF8 MFF NAPA PELI1 RETREG3 RIC3 RNF19B SLC10A1 SLC10A6 SLC35H1 SLC61A1 SLC71A2 SPAG4 STX1A STX4 STX5 TLCD4 TM4SF19 TMCO5A TMEM106A TMEM106C TMEM205 TMEM35A USO1
Entrez ID		127544	9570
HPRD ID		13725	04937
Ensembl ID		ENSG00000116514	ENSG00000108433
Uniprot IDs		Q6ZMZ0	A0A1W2PPP5 A0A1W2PQ77 A0A1W2PQE0 A0A1W2PQM3 A0A1W2PR02 A0A1W2PRC2 A0A1W2PRL0 I3NI02 O14653
PDB IDs			3EG9
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Ubiquitin Conjugating Enzyme Activity	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Ascorbate Homeostasis Positive Regulation Of Protein Localization To Cell Surface Transmembrane Monodehydroascorbate Reductase Activity Synaptobrevin 2-SNAP-25-syntaxin-1a Complex SNARE Binding Vesicle Docking Bile Acid:sodium Symporter Activity Organelle Localization By Membrane Tethering Membrane Fusion Regulation Of Toll Signaling Pathway Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Membrane Docking SNAP Receptor Activity Protein Binding Fatty Acid Elongation, Saturated Fatty Acid Vesicle Fusion Regulation Of Protein Localization To Cell Surface Organelle Membrane Fusion Meiotic Nuclear Membrane Microtubule Tethering Complex SNARE Complex Regulation Of Synaptic Vesicle Priming SNARE Complex Assembly Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Acetylcholine Receptor Binding Very Long-chain Fatty Acid Biosynthetic Process Organelle Fusion Fatty Acid Elongation Endoplasmic Reticulum Organization
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