MIEF2 and CIDEA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MIEF2	CIDEA
Description		mitochondrial elongation factor 2	cell death inducing DFFA like effector a
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Peroxisome Membrane	Nucleus Cytoplasm Mitochondrion Mitochondrial Envelope Lipid Droplet Cytosol
	Molecular Function	Protein Binding	Protein Homodimerization Activity Phosphatidic Acid Binding Lipid Transfer Activity
	Biological Process	Mitochondrion Organization Mitochondrial Fusion Regulation Of Mitochondrion Organization Positive Regulation Of Mitochondrial Fission Positive Regulation Of Protein Targeting To Membrane	Temperature Homeostasis Negative Regulation Of Cytokine Production Lipid Metabolic Process Apoptotic Process Lipid Storage Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Production Response To Stilbenoid Fat Cell Differentiation Negative Regulation Of Lipid Catabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Cellular Response To Cold Intermembrane Lipid Transfer Negative Regulation Of Cold-induced Thermogenesis Lipid Droplet Fusion Negative Regulation Of Execution Phase Of Apoptosis Regulation Of Apoptotic DNA Fragmentation
Pathways			Lipid particle organization Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Drugs
Diseases
GWAS		Change in neurofilament light levels ( 31295725)	Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297)
Interacting Genes		30 interacting genes: AGTRAP ARFIP2 ARL6IP1 ATP5PF CIDEA DNM1L FAM114A2 FAM25A FAM25C FAM25G FKBP7 GSG1 HSD17B13 LIME1 MDK NCALD NCS1 PRB2 PSMF1 RABAC1 REEP6 RHBDD2 SFT2D1 SYP TMEM239 UBQLN1 UBQLN2 UBQLN4 YIF1A ZNF628	5 interacting genes: CIDEB CIDEC MIEF2 UCP1 ZBTB16
Entrez ID		125170	1149
HPRD ID		18074	08380
Ensembl ID		ENSG00000177427	ENSG00000176194
Uniprot IDs		Q96C03	B3KVA2 O60543 Q8N5P9
PDB IDs		5WP9	2EEL
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Polyubiquitin Modification-dependent Protein Binding Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Organization Regulation Of Proteasomal Protein Catabolic Process Endoplasmic Reticulum Membrane Regulation Of Macroautophagy Autophagosome Positive Regulation Of ERAD Pathway GTP-dependent Protein Binding ERAD Pathway	Lipid Droplet Fusion Lipid Transfer Activity Organelle Fusion Execution Phase Of Apoptosis Phosphatidic Acid Binding Lipid Storage Intermembrane Lipid Transfer Regulation Of Triglyceride Metabolic Process Lipid Droplet Organization Cellular Response To Dehydroepiandrosterone Purine Ribonucleotide Binding Lipid Droplet Type 2 Angiotensin Receptor Binding Response To Dehydroepiandrosterone Male Germ-line Stem Cell Asymmetric Division Long-chain Fatty Acid Binding Oxidative Phosphorylation Uncoupler Activity Anion Binding Germ-line Stem Cell Division Cell Death Apoptotic Process Programmed Cell Death Positive Regulation Of NK T Cell Differentiation Regulation Of NK T Cell Differentiation Ossification Involved In Bone Maturation Diet Induced Thermogenesis Lipid Transport Very-low-density Lipoprotein Particle Assembly Cardiolipin Binding Regulation Of Lipid Metabolic Process Cellular Response To Cold Mesonephros Development Asymmetric Cell Division COPI-coated Vesicle Negative Regulation Of Triglyceride Metabolic Process Mitochondrial Envelope COPII Vesicle Coat COPII-coated Vesicle Cargo Loading Mitochondrial Fusion Positive Regulation Of Chondrocyte Differentiation Mitochondrial Transmembrane Transport Positive Regulation Of Mitochondrial Fission Adaptive Thermogenesis Plasma Lipoprotein Particle Assembly Proton Transmembrane Transporter Activity Stem Cell Division Protein-lipid Complex Assembly Negative Regulation Of Lipid Catabolic Process Response To Nutrient Levels Positive Regulation Of Protein Targeting To Membrane
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