TMEM219 and GSG1L

		TMEM219	GSG1L
Description		transmembrane protein 219	GSG1 like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane Membrane Asymmetric Synapse Synapse Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Apoptotic Process	Regulation Of Cell Communication Transmission Of Nerve Impulse Regulation Of Signaling Regulation Of Short-term Neuronal Synaptic Plasticity Synapse Organization Regulation Of Transport Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Pathways		TP53 Regulates Transcription of Death Receptors and Ligands
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety/tension (special factor of neuroticism) ( 30867560) Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Dentures ( 31235808) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Schizophrenia ( 25056061 28991256 29483656) Waist circumference adjusted for body mass index ( 34021172)	Hemoglobin levels in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683) Lateral ventricle temporal horn volume ( 31530798) Obesity-related traits ( 23251661) Refractive error ( 32231278)
Interacting Genes		9 interacting genes: GSG1L KRABD5 PRRT2 PRSS36 SGF29 STX1B ZNF688 ZNF689 ZNF785	3 interacting genes: LXN MAL TMEM219
Entrez ID		124446	146395
HPRD ID		18546	14464
Ensembl ID		ENSG00000149932	ENSG00000169181
Uniprot IDs		A0A024R618 Q86XT9	B3KY67 Q6UXU4
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle Fusion To Plasma Membrane Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Synaptic Vesicle Membrane Organization Negative Regulation Of Short-term Synaptic Potentiation Positive Regulation Of Spontaneous Neurotransmitter Secretion Negative Regulation Of Macropinocytosis Negative Regulation Of Synaptic Vesicle Recycling Vesicle Fusion Negative Regulation Of SNARE Complex Assembly Postsynaptic Density Membrane Organelle Membrane Fusion Regulation Of Calcium-dependent Activation Of Synaptic Vesicle Fusion Methylation-dependent Protein Binding Modulation Of Chemical Synaptic Transmission Negative Regulation Of Vesicle Fusion Organelle Fusion Regulation Of Synaptic Activity Regulation Of Vesicle-mediated Transport Negative Regulation Of Pinocytosis Membrane Fusion Regulation Of Spontaneous Synaptic Transmission Spontaneous Neurotransmitter Secretion SAGA-type Complex Histone H3K36me3 Reader Activity Regulation Of Synaptic Plasticity Calcium Ion-regulated Exocytosis Of Neurotransmitter Establishment Of Protein Localization To Chromatin Neuromuscular Process Controlling Posture Presynapse Nuclear Lamina Synaptic Vesicle Docking Regulation Of Synaptic Vesicle Priming Asymmetric Synapse ATAC Complex Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of SNARE Complex Assembly	Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Protein Localization To Paranode Region Of Axon Protein Localization To Axon Schmidt-Lanterman Incisure Membrane Raft Distribution Membrane Raft Localization Apical Protein Localization Structural Constituent Of Myelin Sheath Membrane Raft Polarization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Central Nervous System Myelination Peptidase Activator Activity Involved In Apoptotic Process Metalloendopeptidase Inhibitor Activity Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Temperature Stimulus Involved In Sensory Perception Detection Of Temperature Stimulus Membrane Raft Organization Plasma Membrane Raft Cell Death Programmed Cell Death Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Enzyme Inhibitor Activity Protein Insertion Into Membrane
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