ABCC2 and RDX

Number of citations of the paper that reports this interaction (PubMedID 25163515)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		ABCC2	RDX
Description		ATP binding cassette subfamily C member 2	radixin
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Intercellular Canaliculus	Ruffle Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Microvillus Adherens Junction Focal Adhesion Membrane Apical Plasma Membrane Lamellipodium Filopodium T-tubule Midbody Cortical Actin Cytoskeleton Cleavage Furrow Stereocilium Cell Projection Apical Part Of Cell Cell Tip Extracellular Exosome Cell Periphery Stereocilium Base
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Organic Anion Transmembrane Transporter Activity ABC-type Xenobiotic Transporter Activity Bilirubin Transmembrane Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity ATP Hydrolysis Activity Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity ABC-type Transporter Activity	RNA Binding Actin Binding Protein Binding Cytoskeletal Protein Binding Protein Domain Specific Binding Cadherin Binding Cell Adhesion Molecule Binding Protein Kinase A Binding ATPase Binding
	Biological Process	Xenobiotic Metabolic Process Xenobiotic Transmembrane Transport Lipid Transport Negative Regulation Of Gene Expression Bile Acid And Bile Salt Transport Bilirubin Transport Heme Catabolic Process Xenobiotic Export From Cell Carboxylic Acid Transport Transmembrane Transport Transepithelial Transport Leukotriene Transport Monoatomic Anion Transmembrane Transport Transport Across Blood-brain Barrier Xenobiotic Transport Across Blood-brain Barrier	Regulation Of Cell Shape Positive Regulation Of Gene Expression Protein Kinase A Signaling Microvillus Assembly Regulation Of Rap Protein Signal Transduction Cellular Response To Platelet-derived Growth Factor Stimulus Apical Protein Localization Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Barbed-end Actin Filament Capping Actin Filament Capping Establishment Of Endothelial Barrier Establishment Of Protein Localization To Plasma Membrane Protein Localization To Plasma Membrane Cellular Response To Thyroid Hormone Stimulus Regulation Of Postsynaptic Neurotransmitter Receptor Diffusion Trapping Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Organelle Assembly Positive Regulation Of Protein Localization To Early Endosome Regulation Of Adherens Junction Organization Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways		Heme degradation ABC-family proteins mediated transport Defective ABCC2 causes DJS Aspirin ADME Paracetamol ADME Atorvastatin ADME	Recycling pathway of L1 Recycling pathway of L1 Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs		ATP Sulfinpyrazone Azvudine	1D-myo-inositol 1,4,5-trisphosphate
Diseases		Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611) Colorectal cancer ( 24737748 26151821) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Serum metabolite levels ( 33031748) Stent thrombosis in response to clopidogrel treatment ( 32472697)	Cognitive function ( 24684796) Computer vision syndrome ( 33941792) Coronary artery disease ( 32469254) Multiple sclerosis ( 31604244)
Interacting Genes		12 interacting genes: AZIN1 CANX HSPA4 MCPH1 NFKB1 NHERF1 NHERF4 PDZK1 RDX SHANK3 TUBB3 UBQLN1	25 interacting genes: ABCC2 ARHGDIA C1QTNF9 CALM1 CPNE1 CPNE2 CPNE4 DRD3 EZR FTCD GNA13 ICAM2 ITGB2 KMT2A L1CAM LINC01554 NHERF1 NHERF2 PRPF38A PSME3 RBPMS ROCK1 TSC1 VPS11 VWA5A
Entrez ID		1244	5962
HPRD ID		03065	01534
Ensembl ID		ENSG00000023839	ENSG00000137710
Uniprot IDs		Q92887	B0YJ88 P35241 Q6PKD3
PDB IDs		8IZQ 8IZR 8JX7 8JXQ 8JXU 8JY4 8JY5 9BR2 9BUK 9C12 9C2I
Enriched GO Terms of Interacting Partners?		Protein-membrane Adaptor Activity Protein Localization To Membrane Intracellular Protein Localization Protein Localization To Plasma Membrane Microvillus Assembly Protein Localization To Cell Periphery Microvillus Organization Localization Within Membrane Filopodium Apical Part Of Cell Cell Periphery Apical Plasma Membrane Microvillus Membrane Regulation Of Transport Stereocilium Brush Border Membrane Regulation Of Cellular Component Size Renal Phosphate Ion Absorption Negative Regulation Of Store-operated Calcium Channel Activity Guanylate Cyclase Inhibitor Activity Brush Border Extracellular Exosome NF-kappaB P50/p65 Complex PDZ Domain Binding Microvillus Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Cell Size Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Netrin Receptor Binding Ornithine Decarboxylase Activator Activity Positive Regulation Of Polyamine Transmembrane Transport Guanylate Kinase-associated Protein Clustering ERAD Pathway Positive Regulation Of Hyaluronan Biosynthetic Process I-kappaB/NF-kappaB Complex Regulation Of Protein Catabolic Process Regulation Of Postsynaptic Neurotransmitter Receptor Diffusion Trapping Type 3 Metabotropic Glutamate Receptor Binding Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Ornithine Decarboxylase Activity Putrescine Biosynthetic Process From Arginine, Via Ornithine Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Negative Regulation Of Vitamin D Biosynthetic Process Signaling Receptor Binding Cellular Localization Regulation Of Monoatomic Ion Transport Scavenger Receptor Binding Stereocilium Base	Type 2 Metabotropic Glutamate Receptor Binding Membrane Docking Type 3 Metabotropic Glutamate Receptor Binding Membrane To Membrane Docking Response To Calcium Ion Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Cell Shape Leukocyte Cell-cell Adhesion Protein Localization To Membrane Microvillus Organization Positive Regulation Of Early Endosome To Late Endosome Transport Microvillus Assembly Calcium-dependent Phospholipid Binding Plasma Membrane Response To Metal Ion Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Rho Protein Signal Transduction Microvillus Receptor Internalization Uropod Protein Localization To Plasma Membrane Cellular Response To Calcium Ion Regulation Of Intracellular Signal Transduction Establishment Of Epithelial Cell Apical/basal Polarity Protein Localization To Cell Periphery Regulation Of Early Endosome To Late Endosome Transport Focal Adhesion Extracellular Exosome Associative Learning Cell Periphery Regulation Of Cell Morphogenesis G Protein-coupled Dopamine Receptor Signaling Pathway Cell-matrix Adhesion Ruffle Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Negative Regulation Of Intracellular Signal Transduction Cell-cell Adhesion Acid Secretion Microvillus Membrane Gland Morphogenesis Establishment Of Epithelial Cell Polarity Localization Within Membrane Positive Regulation Of Focal Adhesion Assembly Cortical Actin Cytoskeleton Organization Monocarboxylic Acid Transport Regulation Of Vesicle-mediated Transport Protein-membrane Adaptor Activity
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