CCR5 and CCL16

Number of citations of the paper that reports this interaction (PubMedID 11470772)
0

Data Source:
HPRD (in vivo)

		CCR5	CCL16
Description		C-C motif chemokine receptor 5	C-C motif chemokine ligand 16
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Extracellular Region Extracellular Space
	Molecular Function	Virus Receptor Activity Actin Binding Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding Identical Protein Binding Chemokine (C-C Motif) Ligand 5 Binding	Cytokine Activity Protein Binding Chemokine Activity Chemoattractant Activity CCR Chemokine Receptor Binding
	Biological Process	MAPK Cascade Dendritic Cell Chemotaxis Calcium Ion Transport Apoptotic Process Chemotaxis Defense Response Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling Signaling Symbiont Entry Into Host Cell Cell Chemotaxis Chemokine-mediated Signaling Pathway Response To Cholesterol Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Negative Regulation Of Macrophage Apoptotic Process	Chemotaxis Inflammatory Response Immune Response Cell Communication Cell-cell Signaling Positive Regulation Of Cell Migration Eosinophil Chemotaxis Positive Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway
Pathways		Binding and entry of HIV virion Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		Maraviroc AMD-070 CCR5 mAb Leronlimab Aplaviroc Vicriviroc Ibalizumab INCB-9471
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Celiac disease ( 20190752) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 26192919) Type 1 diabetes ( 25751624) Ulcerative colitis ( 26192919 28067908)	Initial pursuit acceleration ( 29064472)
Interacting Genes		43 interacting genes: AFP ARL6IP5 ARRB1 CCL11 CCL13 CCL14 CCL16 CCL2 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCL8 CD4 CST9L CTBP2 CXCR4 DNM2 EMP1 ETV5 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GRK2 GRK3 IL24 JAK1 JAK2 LCK ORM1 PRAF2 PSMA5 PTK2 PTK2B SLC20A2 STAT1 STAT3 STAT5A TXK	9 interacting genes: CCL5 CCR1 CCR5 CCR8 HRH4 MX1 SDF2 SMG6 UBQLN2
Entrez ID		1234	6360
HPRD ID		03223	03233
Ensembl ID		ENSG00000160791	ENSG00000275152
Uniprot IDs		P51681 Q38L21	O15467
PDB IDs		2L87 2MZX 2RLL 2RRS 4MBS 5UIW 5YD3 5YD4 5YD5 5YY4 6FGP 6MEO 6MET 7F1Q 7F1R 7F1S 7NJZ 7NW3 7O7F 8AS2 8AS3	5LTL 7SCT 8FK9
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway CCR Chemokine Receptor Binding Cytokine-mediated Signaling Pathway Chemokine Activity G Protein-coupled Receptor Signaling Pathway Eosinophil Chemotaxis Eosinophil Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Antimicrobial Humoral Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cell Chemotaxis Cytokine Activity CCR5 Chemokine Receptor Binding Immune System Process Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Cell Migration Humoral Immune Response Regulation Of Cell Motility Signal Transduction Regulation Of Locomotion Granulocyte Chemotaxis Leukocyte Migration Chemotaxis Granulocyte Migration Defense Response Cell Migration Leukocyte Chemotaxis Inflammatory Response Locomotion Response To Other Organism Response To External Biotic Stimulus Cell Motility Regulation Of Lymphocyte Chemotaxis Myeloid Leukocyte Migration Defense Response To Symbiont Positive Regulation Of Natural Killer Cell Chemotaxis Defense Response To Other Organism Guanyl Nucleotide Binding CCR1 Chemokine Receptor Binding G Protein-coupled Receptor Binding Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Lymphocyte Chemotaxis Cell Surface Receptor Signaling Pathway Via STAT Non-membrane Spanning Protein Tyrosine Kinase Activity G-protein Beta/gamma-subunit Complex Binding Protein Kinase Activity Interleukin-9-mediated Signaling Pathway	Chemokine Receptor Activity Chemokine-mediated Signaling Pathway Dendritic Cell Migration Dendritic Cell Chemotaxis C-C Chemokine Binding C-C Chemokine Receptor Activity Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Chemokine (C-C Motif) Ligand 5 Binding Positive Regulation Of Cytosolic Calcium Ion Concentration Cytokine-mediated Signaling Pathway Cell Chemotaxis Response To Cytokine Response To Peptide Negative Regulation Of Macrophage Apoptotic Process Chemotaxis Mononuclear Cell Migration G Protein-coupled Receptor Signaling Pathway Locomotion G Protein-coupled Receptor Activity Cellular Response To Cytokine Stimulus Leukocyte Chemotaxis Positive Regulation Of Neuroinflammatory Response Negative Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Monocyte Chemotaxis Monocyte Chemotaxis Calcium-mediated Signaling Inflammatory Response Regulation Of Monocyte Chemotaxis Regulation Of Myeloid Cell Apoptotic Process Immune Response Cell-cell Signaling Leukocyte Migration Regulation Of Neuroinflammatory Response Signaling Calcium Ion Transport Cell Communication Negative Regulation Of Viral Genome Replication Defense Response G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Leukocyte Apoptotic Process Coreceptor Activity Chemokine Receptor Antagonist Activity Chemokine (C-C Motif) Ligand 5 Signaling Pathway CCR4 Chemokine Receptor Binding Intracellular Signaling Cassette External Side Of Plasma Membrane Negative Regulation Of Viral Process Regulation Of Viral Genome Replication Cell Migration Chemokine (C-C Motif) Ligand 7 Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?