PSMB11 and PROP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PSMB11	PROP1
Description		proteasome subunit beta 11	PROP paired-like homeobox 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Beta-catenin Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Proteolysis T Cell Differentiation In Thymus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process CD8-positive, Alpha-beta T Cell Differentiation Proteolysis Involved In Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Nervous System Development Central Nervous System Development Animal Organ Morphogenesis Dorsal/ventral Pattern Formation Cell Migration Hypothalamus Cell Differentiation Pituitary Gland Development Adenohypophysis Development Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Gland Development Hypophysis Morphogenesis Somatotropin Secreting Cell Differentiation
Pathways		Proteasome assembly Proteasome assembly
Drugs
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Red cell distribution width ( 27863252 28957414 32888494)
Interacting Genes		5 interacting genes: ATG5 HGS PITX1 PROP1 TLX3	55 interacting genes: ABHD11 ACTMAP ARSA BATF2 C1orf94 C6orf15 CFAP68 CIMIP2A COX6B2 CRYBA1 CYSRT1 DAZAP2 EFEMP2 FAM168A HDHD3 HESX1 HNRNPAB HNRNPF HOXA1 INTS11 KHDC1 KRTAP13-1 KRTAP19-1 KRTAP19-6 KRTAP19-7 KRTAP6-3 KRTAP8-1 MAGED1 METTL15 METTL27 NR1D2 OLIG3 OXER1 P4HA3 PITX2 PLEKHB2 POU6F2 PSMB11 PSMB4 RNF144B RNF4 SMUG1 SPMIP6 SUMO1 TBX22 TEKT4 TEKT5 TENT5B TINAGL1 TLE5 TMEM42 TRIM42 UBE2I UFSP1 ZNF503
Entrez ID		122706	5626
HPRD ID		19472	03325
Ensembl ID		ENSG00000222028	ENSG00000175325
Uniprot IDs		A5LHX3 B3KVC3	A0A0G2JQ02 O75360
PDB IDs
Enriched GO Terms of Interacting Partners?		Pituitary Gland Development Branchiomeric Skeletal Muscle Development Myoblast Fate Commitment Sequence-specific Double-stranded DNA Binding Somatotropin Secreting Cell Differentiation Central Nervous System Development Hypophysis Morphogenesis ESCRT-0 Complex Phagocytic Vesicle Lumen Macroautophagy Negative Regulation Of Autophagic Cell Death Otolith Development Phagophore Atg8-family Ligase Activity Response To Fluoride Positive Regulation Of Viral Translation Negative Stranded Viral RNA Replication Cellular Response To Nitrosative Stress Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression System Development Hypothalamus Cell Differentiation Positive Regulation Of Stress Granule Assembly Chaperone-mediated Autophagy Response To Iron(II) Ion Viral RNA Genome Replication Atg12-Atg5-Atg16 Complex Positive Regulation Of Mucus Secretion DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Regulation Of Mucus Secretion Response To Nitrosative Stress Gland Development Adenohypophysis Development Autophagy Ventricular Cardiac Muscle Cell Development Cellular Response To Nitrogen Starvation Cellular Developmental Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Secretion Negative Thymic T Cell Selection Regulation Of Stress Granule Assembly Regulation Of Respiratory Gaseous Exchange By Nervous System Process GABAergic Neuron Differentiation Cardiac Muscle Cell Apoptotic Process Negative T Cell Selection Transferase Complex	Axonemal A Tubule Inner Sheath Intermediate Filament Sperm Flagellum Sperm Motility Flagellated Sperm Motility Cilium Movement Involved In Cell Motility Cilium-dependent Cell Motility Small Protein Activating Enzyme Binding Positive Regulation Of Anoikis Protein Binding Cilium Movement Proteasome Core Complex, Beta-subunit Complex Motile Cilium
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