TDRD9 and COA8

		TDRD9	COA8
Description		tudor domain containing 9	cytochrome c oxidase assembly factor 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm PiP-body	Mitochondrion Mitochondrial Inner Membrane Membrane Matrix Side Of Mitochondrial Inner Membrane
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity ATP Binding Hydrolase Activity ATP Hydrolysis Activity	Protein Binding
	Biological Process	Male Meiotic Nuclear Division Male Meiosis I Spermatogenesis Fertilization Transposable Element Silencing Cell Differentiation Regulatory NcRNA-mediated Gene Silencing PiRNA Processing Meiotic Cell Cycle Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation Transposable Element Silencing By PiRNA-mediated DNA Methylation	Response To Reactive Oxygen Species Apoptotic Process Mitochondrial Cytochrome C Oxidase Assembly Protein Stabilization Intrinsic Apoptotic Signaling Pathway
Pathways		PIWI-interacting RNA (piRNA) biogenesis
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Hip bone mineral density and total body fat mass (bivariate analysis) ( 32963334) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Refractive error ( 32231278) Schizophrenia ( 29483656)	Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)
Interacting Genes		4 interacting genes: CLK1 COA8 RNF10 TRMT61A	5 interacting genes: AHNAK2 IGHV5-78 INF2 TDRD9 TRMT61A
Entrez ID		122402	84334
HPRD ID		15484	12637
Ensembl ID		ENSG00000156414	ENSG00000256053
Uniprot IDs		Q86WA0 Q8NDG6	A0A6Q8JUI0 G3V4L6 Q96IL0
PDB IDs
Enriched GO Terms of Interacting Partners?		Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Matrix Side Of Mitochondrial Inner Membrane MRNA (adenine-N1-)-methyltransferase Activity TRNA (m1A) Methyltransferase Complex TRNA (adenine(58)-N1)-methyltransferase Activity Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Schwann Cell Proliferation	MRNA (adenine-N1-)-methyltransferase Activity TRNA (m1A) Methyltransferase Complex TRNA (adenine(58)-N1)-methyltransferase Activity Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation PiP-body
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