NEDD1 and RND1

Number of citations of the paper that reports this interaction (PubMedID 30797814)
0

Data Source:
BioGRID (two hybrid)

		NEDD1	RND1
Description		NEDD1 gamma-tubulin ring complex targeting factor	Rho family GTPase 1
Image		No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Spindle Pole Fibrillar Center Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Ciliary Basal Body Apical Part Of Cell	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Actin Cytoskeleton Membrane
	Molecular Function	Protein Binding Gamma-tubulin Binding	Nucleotide Binding GTPase Activity Signaling Receptor Binding Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Mitotic Cell Cycle Microtubule Nucleation Cell Division	Actin Filament Organization Negative Regulation Of Cell Adhesion Signal Transduction Small GTPase-mediated Signal Transduction Neuron Remodeling Regulation Of Actin Cytoskeleton Organization
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse RND1 GTPase cycle
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Autism ( 24189344) Breast size ( 22747683) Cerebral amyloid angiopathy in Alzheimer’s disease ( 34020725) Frontotemporal dementia ( 29724592) Frontotemporal dementia with GRN mutation ( 29724592) joint destruction in rheumatoid arthritis (rapid vs slow) ( 33585033) Manganese levels ( 26025379) Obstructive sleep apnea (BMI adjusted) ( 33243845)	Bipolar disorder ( 21926972)
Interacting Genes		6 interacting genes: CDK1 CEBPA EP300 FBLN1 PLK1 RND1	23 interacting genes: ARFIP2 CCNI COPS2 CREB3L2 EEF1A1 FRS2 FRS3 GPX8 GRB7 ID3 KRT6A MYH7 MYOM3 MYZAP NEDD1 PAIP1 PDE6D PLXNA1 PLXNB1 PLXNB2 SHMT2 UBXN11 ZNF212
Entrez ID		121441	27289
HPRD ID		02655	12357
Ensembl ID		ENSG00000139350	ENSG00000172602
Uniprot IDs		A8K1Z3 Q8NHV4	Q92730
PDB IDs			2CLS 2REX 3Q3J
Enriched GO Terms of Interacting Partners?		Mitotic Nuclear Membrane Disassembly Protein Localization To Chromosome Positive Regulation Of Protein Localization To Nucleus STAT Family Protein Binding Membrane Disassembly Nuclear Membrane Disassembly Regulation Of Protein Localization To Nucleus Protein Localization To Site Of Double-strand Break Negative Regulation Of Stem Cell Proliferation Mitotic G2 DNA Damage Checkpoint Signaling Intracellular Signal Transduction Spindle Microtubule Chromosome Condensation Intracellular Signaling Cassette Positive Regulation Of Protein Import Into Nucleus Nuclear Membrane Organization Centrosome Cycle Mitotic G2/M Transition Checkpoint G2/M Transition Of Mitotic Cell Cycle Protein Localization To Chromatin Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Import Into Nucleus Protein Destabilization Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Cell Cycle G2/M Phase Transition Pronuclear Fusion Positive Regulation Of Gene Expression Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Biosynthetic Process Regulation Of Organelle Organization Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Signal Transduction Positive Regulation Of Protein Localization Mitotic DNA Damage Checkpoint Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Microtubule Organizing Center Organization Regulation Of Stem Cell Proliferation Negative Regulation Of Macromolecule Metabolic Process Chromatin DNA Binding	Semaphorin Receptor Complex Semaphorin Receptor Activity Semaphorin-plexin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Synapse Assembly
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