SP7 and NFIX

Number of citations of the paper that reports this interaction (PubMedID 35140242)
106

Data Source:
BioGRID (pull down)

		SP7	NFIX
Description		Sp7 transcription factor	nuclear factor I X
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding DEAD/H-box RNA Helicase Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Osteoblast Differentiation Regulation Of Transcription By RNA Polymerase II Gene Expression Response To Insulin Cellular Response To Zinc Ion Starvation Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Differentiation Diphosphate Metabolic Process Cementum Mineralization Positive Regulation Of Stem Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		RUNX2 regulates osteoblast differentiation	RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Bone mineral density (spine) ( 19079262 19801982) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 31562340) Hypospadias (moderate to severe) ( 31856834) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lumbar spine bone mineral density ( 22504420) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Serum alkaline phosphatase levels ( 33547301) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Bipolar disorder ( 28115744) Body mass index ( 25673413) Brain morphology (MOSTest) ( 32665545) Clozapine-induced agranulocytosis ( 25187353) Cortical surface area ( 32963231) Cortical volume ( 32963231) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Hemoglobin ( 32888494) Hip index ( 34021172) Intelligence (MTAG) ( 29326435) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Refractive error ( 32231278)
Interacting Genes		12 interacting genes: CBL CBLB DRC4 FAM124B FBXW7 HNF1B KRT72 MAPK14 NFIC NFIX QARS1 TRIM62	32 interacting genes: ARL4A GADD45B GZMA JMJD6 LHX4 MATK MLLT1 NFIB NRTN PAX2 PAX6 PAX7 PAX8 PIR POLR2E PRDM1 QRICH1 RFX1 RWDD1 SKI SOX10 SOX15 SOX17 SOX5 SOX6 SOX9 SP7 TBR1 TLX2 TLX3 YY1 ZNF614
Entrez ID		121340	4784
HPRD ID		05971	01234
Ensembl ID		ENSG00000170374	ENSG00000008441
Uniprot IDs		Q8TDD2	B4DHW2 D2DXM9 Q14938
PDB IDs			7QQD 7QQE
Enriched GO Terms of Interacting Partners?		Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Cell Communication Regulation Of Signaling Ubiquitin-protein Transferase Activity Protein Ubiquitination Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Receptor Tyrosine Kinase Binding Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Signal Transduction Post-translational Protein Modification Ubiquitin Protein Ligase Activity Animal Organ Development Regulation Protein Catabolic Process At Postsynapse Cellular Response To UV Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Synaptic Membrane Adhesion Cis-regulatory Region Sequence-specific DNA Binding Glutamine-tRNA Ligase Activity Glutaminyl-tRNA Aminoacylation Regulation Of Branch Elongation Involved In Ureteric Bud Branching Mesonephric Duct Morphogenesis Hepatoblast Differentiation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Regulation Of Pronephros Size Positive Regulation Of Antifungal Innate Immune Response Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Negative Regulation Of Hepatocyte Proliferation Phosphothreonine Residue Binding Negative Regulation Of Cell Communication	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Chromatin DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Animal Organ Development Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cellular Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Positive Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Metanephric Nephron Tubule Formation Regulation Of Gene Expression Cell Fate Commitment Gene Expression Regulation Of Macromolecule Biosynthetic Process Glial Cell Differentiation Negative Regulation Of Developmental Process Metanephric Tubule Formation Positive Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Macromolecule Metabolic Process Lacrimal Gland Development Developmental Process Glial Cell Fate Specification Ureter Development Regulation Of Developmental Process Regulation Of Cell Differentiation Neuron Differentiation Positive Regulation Of Macromolecule Metabolic Process Retina Development In Camera-type Eye Regulation Of Stem Cell Differentiation Pattern Specification Process Regionalization
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