CLTC and AFTPH

Number of citations of the paper that reports this interaction (PubMedID 15758025)
32

Data Source:
BioGRID (pull down)

		CLTC	AFTPH
Description		clathrin heavy chain	aftiphilin
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Trans-Golgi Network Spindle Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Focal Adhesion Membrane Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Protein-containing Complex Centriolar Satellite Endolysosome Membrane Melanosome Clathrin-coated Endocytic Vesicle Extracellular Exosome Clathrin Complex Mitotic Spindle Extracellular Vesicle Mitotic Spindle Microtubule	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol AP-1 Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Double-stranded RNA Binding Structural Molecule Activity Protein Binding Protein Kinase Binding Clathrin Light Chain Binding Low-density Lipoprotein Particle Receptor Binding Disordered Domain Specific Binding Ubiquitin-specific Protease Binding	Protein Binding Clathrin Binding
	Biological Process	Mitotic Cell Cycle Osteoblast Differentiation Intracellular Protein Transport Receptor-mediated Endocytosis Autophagy Vesicle-mediated Transport Receptor Internalization Transferrin Transport Retrograde Transport, Endosome To Golgi Clathrin Coat Assembly Cell Division Regulation Of Mitotic Spindle Organization Clathrin Coat Disassembly Clathrin-dependent Endocytosis Amyloid-beta Clearance By Transcytosis Negative Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Protein Localization To Plasma Membrane	Protein Transport Intracellular Transport
Pathways		Entry of Influenza Virion into Host Cell via Endocytosis Retrograde neurotrophin signalling Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance RHOU GTPase cycle RHOV GTPase cycle ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS			Delirium ( 29631748) Lung adenocarcinoma ( 31326317) Metabolite levels ( 23823483)
Interacting Genes		70 interacting genes: ACO1 AFTPH AMPH ANXA1 AP1B1 AP1G1 AP3B1 AP3B2 ARF6 ARMCX3 ARR3 ARRB1 ARRB2 BTG3 C10orf88 CEBPA CLINT1 CLTA CLTB DNAJC6 DSCAM DSCR9 DUX4 EPN1 EPN2 ERG FYN GAK GGA1 GGA2 GGA3 GRIN1 GRIN2D HGS HIP1 HIP1R ITSN1 KIT LDLRAP1 MAP3K10 MAU2 NCALD NDRG1 OCRL OPTN PICALM PPP1CC PRKACA PXN QARS1 RIPK4 SCYL2 SMAP1 SNX5 SNX9 SPATC1L SRC STAMBP SUMO2 SYNJ1 TFAP2A TNK2 TOM1 USP7 VCL WNK1 XRCC6 YWHAG YWHAQ ZFYVE9	11 interacting genes: AP1G1 AP1G2 CLTC GGA1 GGA2 GGA3 LIG4 MAP1LC3B PEX14 STAT5B UBE3A
Entrez ID		1213	54812
HPRD ID		00350	10635
Ensembl ID		ENSG00000141367	ENSG00000119844
Uniprot IDs		A0A087WVQ6 Q00610	A0A8Q3SI61 A0A8Q3SIA4 A0A8Q3WKU6 A0A8Q3WM48 Q53GW0 Q6ULP2
PDB IDs		2XZG 4G55 6E4L 6QNN 6QNP 7BN1 7BN2 7ZX4 9C0Y 9C0Z
Enriched GO Terms of Interacting Partners?		Endocytosis Clathrin Binding Vesicle-mediated Transport Import Into Cell Clathrin-coated Vesicle Cytoplasmic Vesicle Clathrin-coated Pit Receptor-mediated Endocytosis Early Endosome Synaptic Vesicle Endocytosis Regulation Of Vesicle-mediated Transport Cytosol Presynaptic Endocytosis Endosome Establishment Of Localization In Cell Intracellular Transport Regulation Of Endocytosis Clathrin-dependent Endocytosis Regulation Of Receptor-mediated Endocytosis Cellular Localization Establishment Of Protein Localization Clathrin Vesicle Coat Clathrin Coat Assembly Clathrin Heavy Chain Binding Phosphatidylinositol Binding Protein Transport Protein Localization To Cell Surface Intracellular Protein Localization Cytoplasm Vesicle-mediated Transport In Synapse Clathrin-coated Vesicle Membrane Regulation Of Transport Clathrin Coat Of Coated Pit Early Endosome Membrane Receptor Internalization Intracellular Protein Transport Golgi Apparatus Cytoplasmic Vesicle Membrane Presynapse Phospholipid Binding Regulation Of Clathrin Coat Assembly Synaptic Vesicle Uncoating Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Endosomal Transport Membrane Coat Perinuclear Region Of Cytoplasm Protein Domain Specific Binding Positive Regulation Of Cellular Component Organization Clathrin Coat Disassembly Clathrin Adaptor Activity	Post-Golgi Vesicle-mediated Transport Intracellular Protein Transport Trans-Golgi Network Golgi Vesicle Transport Protein Localization To Cell Surface Protein Transport Golgi To Plasma Membrane Protein Transport Vesicle-mediated Transport Intracellular Transport Establishment Of Protein Localization Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Cellular Localization Establishment Of Localization In Cell Clathrin-coated Vesicle Small GTPase Binding Endosome Membrane AP-1 Adaptor Complex Intracellular Protein Localization Ubiquitin Binding Phosphatidylinositol Binding Clathrin Adaptor Activity Endosome Golgi To Vacuole Transport Cytosolic Transport Intracellular Vesicle Vesicle-mediated Transport To The Plasma Membrane Protein-containing Complex Disassembly Vacuolar Transport Membrane Coat Cytoplasmic Vesicle Membrane Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Protein Localization To Plasma Membrane Positive Regulation Of Natural Killer Cell Mediated Immunity Early Endosome Membrane Establishment Of Protein Localization To Membrane T Cell Differentiation In Thymus Protein Localization To Cell Periphery Regulation Of Natural Killer Cell Mediated Cytotoxicity Endosomal Transport Regulation Of Natural Killer Cell Mediated Immunity Establishment Of Integrated Proviral Latency Peroxisome Transport Along Microtubule Sperm Entry Positive Regulation Of Golgi Lumen Acidification Positive Regulation Of Leukocyte Mediated Cytotoxicity Golgi Apparatus Positive Regulation Of Cell Killing Protein Localization To Membrane Clathrin-coated Pit
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