ZNF641 and SQLE

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ZNF641	SQLE
Description		zinc finger protein 641	squalene epoxidase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Squalene Monooxygenase Activity Protein Binding Oxidoreductase Activity Flavin Adenine Dinucleotide Binding FAD Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Lipid Metabolic Process Cholesterol Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process Sterol Biosynthetic Process Regulation Of Cell Population Proliferation Lipid Droplet Formation Response To Biphenyl
Pathways		Generic Transcription Pathway	Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs			Naftifine Terbinafine Butenafine Ellagic acid
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462 31152163) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Red blood cell count ( 27863252)	Amyotrophic lateral sclerosis ( 24931836) Amyotrophic lateral sclerosis or frontotemporal dementia ( 24931836) Metabolite levels ( 23823483)
Interacting Genes		8 interacting genes: APP DTX2 KDM1A LMO1 LMO2 LMO3 SCNM1 SQLE	8 interacting genes: ALDOC BCL2L13 CREB3 CREB3L1 MARCHF6 REEP4 TMEM14B ZNF641
Entrez ID		121274	6713
HPRD ID		08711	11802
Ensembl ID		ENSG00000167528	ENSG00000104549
Uniprot IDs		Q96N77	Q14534
PDB IDs			6C6N 6C6P 6C6R
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Binding Transcription Coactivator Activity Neuron Maturation Positive Regulation Of Transcription By RNA Polymerase II Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of RNA Biosynthetic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Positive Regulation Of DNA-templated Transcription Squalene Monooxygenase Activity Flavin Adenine Dinucleotide Binding Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Enzyme Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of RNA Metabolic Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Nucleobase-containing Compound Metabolic Process Lipoprotein Particle Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To CAMP Regulation Of T Cell Homeostatic Proliferation Response To Biphenyl Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Metal Ion Binding Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Protein Demethylase Activity Response To Purine-containing Compound Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Amyloid Fibril Formation	ADP Catabolic Process Pyruvate Metabolic Process ADP Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Glycolytic Process Ribonucleoside Diphosphate Catabolic Process Response To Endoplasmic Reticulum Stress ER Ubiquitin Ligase Complex Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Deacetylase Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Purine Nucleotide Catabolic Process Nucleoside Diphosphate Metabolic Process Response To Unfolded Protein Endoplasmic Reticulum Membrane Regulation Of Response To Endoplasmic Reticulum Stress Nucleotide Catabolic Process Nicotinamide Nucleotide Metabolic Process Carbohydrate Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Fructose-bisphosphate Aldolase Activity Extracellular Matrix Constituent Secretion Glucose Metabolic Process Nucleoside Phosphate Catabolic Process Release From Viral Latency ATP Metabolic Process Hexose Metabolic Process Monosaccharide Metabolic Process Carbohydrate Derivative Catabolic Process Organophosphate Catabolic Process Endoplasmic Reticulum CCR1 Chemokine Receptor Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Fructose 1,6-bisphosphate Metabolic Process Negative Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Cholesterol Metabolic Process Carbohydrate Derivative Metabolic Process CAMP Response Element Binding Protein Binding Mitotic Nuclear Membrane Reassembly Negative Regulation Of Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process CAMP Response Element Binding Fructose Metabolic Process Endoplasmic Reticulum Mannose Trimming
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