CLTA and HIP1

Number of citations of the paper that reports this interaction (PubMedID 11889126)
0

Data Source:
HPRD (in vitro)

		CLTA	HIP1
Description		clathrin light chain A	huntingtin interacting protein 1
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Golgi Apparatus Spindle Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Membrane Clathrin Coat Clathrin Vesicle Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Endolysosome Membrane Clathrin-coated Endocytic Vesicle Clathrin Complex Presynaptic Endocytic Zone Membrane Postsynaptic Endocytic Zone	Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Endomembrane System Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Cortical Actin Cytoskeleton Cytoplasmic Vesicle Synapse Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Structural Molecule Activity Protein Binding Clathrin Heavy Chain Binding Peptide Binding Protein-containing Complex Binding GTPase Binding	Actin Binding Epidermal Growth Factor Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Clathrin Binding Clathrin Light Chain Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Glutamate Receptor Binding AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Protein Heterodimerization Activity Actin Filament Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Intracellular Protein Transport Endocytosis Vesicle-mediated Transport Clathrin Coat Assembly Synaptic Vesicle Endocytosis Cell Division Clathrin-dependent Endocytosis	Endocytosis Apoptotic Process Actin Filament Organization Regulation Of Endocytosis Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Protein Stabilization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Apoptotic Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Presynaptic Modulation Of Chemical Synaptic Transmission Neurotransmitter Receptor Transport Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		Entry of Influenza Virion into Host Cell via Endocytosis Retrograde neurotrophin signalling Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance	Clathrin-mediated endocytosis ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bisphosphonate-associated atypical femoral fracture ( 31006051)	Age-related nuclear cataracts ( 24951543) Alcoholism (12-month weekly alcohol consumption) ( 21529783) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 26961502 28448500 28892062 25673413) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Interleukin-6 levels ( 22205395) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Systemic lupus erythematosus ( 26663301) White blood cell count (basophil) ( 27863252)
Interacting Genes		11 interacting genes: CEBPA CLTC EGFR HIP1 HIP1R HSPA8 IFT57 MAP1LC3B RGS2 SHANK3 SYNJ1	37 interacting genes: AP2A1 AP2B1 APAF1 CASP3 CASP8 CASP9 CFAP53 CLTA CLTB CLTC CYRIB DAZAP2 DVL2 EHHADH EIF6 FAM168A FBXO25 HIP1R HTT IFT57 ITSN1 LITAF LNX1 MAP3K1 MAPK6 NECAP1 PFDN1 RAD23B REL RPRM RPS10 SMURF1 SYT17 TCEA2 TCEANC TFAP2A UBC
Entrez ID		1211	3092
HPRD ID		00351	03461
Ensembl ID		ENSG00000122705	ENSG00000127946
Uniprot IDs		C9J8P9 P09496	B4DK46 O00291
PDB IDs		6E5N	2NO2 2QA7 3I00
Enriched GO Terms of Interacting Partners?		Vesicle Uncoating Clathrin Coat Disassembly Clathrin Light Chain Binding Clathrin Coat Assembly Protein-containing Complex Disassembly Protein Depolymerization Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Clathrin Coat Of Coated Pit Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of ERBB Signaling Pathway Clathrin-coated Vesicle Learning Or Memory Regulation Of Cellular Component Organization Cognition Clathrin Adaptor Activity Phospholipid Binding Protein-containing Complex Organization Embryonic Placenta Development Endocytosis Phosphatidylinositol-3,4-bisphosphate Binding Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Supramolecular Fiber Organization Phosphatidylinositol-3,5-bisphosphate Binding Brown Fat Cell Differentiation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Component Assembly Positive Regulation Of ERBB Signaling Pathway Clathrin-coated Vesicle Membrane Clathrin Binding Actin Filament Binding Postsynapse Organization Positive Regulation Of Cellular Component Organization Import Into Cell RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Multivesicular Body, Internal Vesicle Lumen Endomembrane System Cortical Actin Cytoskeleton Chaperone-mediated Autophagy Translocation Complex Disassembly Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Positive Regulation Of Endosome Organization Positive Regulation Of Clathrin Coat Assembly Autophagy Synaptic Membrane Cytosol Ubiquitin Protein Ligase Binding Cytoplasm Clathrin-coated Endocytic Vesicle Membrane Clathrin-coated Pit	Clathrin-coated Pit Clathrin-coated Endocytic Vesicle Postsynaptic Endocytic Zone Clathrin-dependent Endocytosis Clathrin Coat Presynaptic Endocytosis Clathrin Coat Of Trans-Golgi Network Vesicle Synaptic Vesicle Endocytosis Vesicle-mediated Transport In Synapse Endolysosome Membrane Receptor-mediated Endocytosis Clathrin Coat Assembly Response To Anesthetic Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Clathrin Vesicle Coat Response To Cobalt Ion Endocytosis Presynaptic Endocytic Zone Membrane Clathrin Adaptor Activity Apoptosome Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Hyaluronan Biosynthetic Process Protein-containing Complex Import Into Cell Tube Closure Glial Cell Apoptotic Process Cytoplasmic Vesicle Regulation Of Hyaluronan Biosynthetic Process Death-inducing Signaling Complex Clathrin Light Chain Binding Cytosol Vesicle-mediated Transport Postsynaptic Neurotransmitter Receptor Internalization Clathrin Complex Protein Binding Intracellular Transport Positive Regulation Of Pyroptotic Inflammatory Response Tube Formation Clathrin Heavy Chain Binding AP-2 Adaptor Complex Fibroblast Apoptotic Process Establishment Of Localization In Cell Cytoplasm Clathrin Adaptor Complex Cysteine-type Endopeptidase Activity Protein Kinase Binding Clathrin-coated Endocytic Vesicle Membrane Kidney Development Receptor Internalization
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