NOPCHAP1 and BMX

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NOPCHAP1	BMX
Description		NOP protein chaperone 1	BMX non-receptor tyrosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Ruffle Membrane
	Molecular Function	Protein Binding Box C/D Methylation Guide SnoRNP Complex Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding
	Biological Process	Box C/D SnoRNP Assembly	Adaptive Immune Response Protein Phosphorylation Phosphatidylinositol Biosynthetic Process Apoptotic Process Cell Adhesion Signal Transduction Mesoderm Development Intracellular Signal Transduction Protein Autophosphorylation B Cell Receptor Signaling Pathway
Pathways			Apoptotic cleavage of cellular proteins Synthesis of PIPs at the plasma membrane
Drugs			Fostamatinib Zanubrutinib
Diseases
GWAS
Interacting Genes		2 interacting genes: BMX TBC1D23	26 interacting genes: APP BCAR1 BIRC2 BTK CASP3 CAV1 CLNK EGFR ERBB2 FBXO25 ITK KDR NOPCHAP1 PAK1 PTK2 PTPN21 PTPRD RAP1A RUFY1 RUFY2 SRC STAT1 STAT3 STAT5A TEC TNFRSF1B
Entrez ID		121053	660
HPRD ID		17556	02111
Ensembl ID		ENSG00000151131	ENSG00000102010
Uniprot IDs		Q8N5I9	P51813
PDB IDs			2EKX 2YS2 3SXR 3SXS 6I99 8X2A
Enriched GO Terms of Interacting Partners?		Vesicle Tethering To Golgi	Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Immune Response Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Intracellular Signal Transduction Regulation Of Cell Differentiation Regulation Of Defense Response Positive Regulation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Positive Regulation Of Cell Migration Non-membrane Spanning Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Motility Regulation Of Multicellular Organismal Process Positive Regulation Of Immune System Process Positive Regulation Of Locomotion Positive Regulation Of Protein Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Endocytosis Positive Regulation Of Defense Response Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Regulation Of Cell Activation Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Differentiation Membrane Raft Positive Regulation Of Intracellular Signal Transduction Protein Kinase Activity Regulation Of Developmental Process Immune Response-activating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Modification Process Regulation Of Epithelial Cell Proliferation Regulation Of Vesicle-mediated Transport Immune System Process Regulation Of Cell Junction Assembly ERBB Signaling Pathway Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Inflammatory Response Positive Regulation Of Signal Transduction
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