CLK2 and RSRP1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		CLK2	RSRP1
Description		CDC like kinase 2	arginine and serine rich protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Nuclear Speck	Nucleus
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	Protein Phosphorylation Response To Ionizing Radiation Regulation Of RNA Splicing Negative Regulation Of Gluconeogenesis Protein Autophosphorylation	Spliceosomal Complex Assembly
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		62 interacting genes: AKT1 AP2M1 ASPSCR1 CACTIN CLASRP CLK1 CLK3 CPSF7 DDIT4L ECE1 EHHADH GMCL1 GTPBP2 KLHL2 LNX1 LUC7L LUZP4 MRPL2 MRPL4 NIP7 NXF1 PATL1 PRM1 PRPF38A PRPF6 PTPN1 RBM39 RBM6 RNF8 RNPS1 RSRP1 SDCBP SNRNP27 SRPK2 SRRM1 SRSF1 SRSF10 SRSF8 TACC2 TRIM27 TRIM50 U2AF1 UBE2I UBL5 YTHDC1 YTHDF1 YWHAG ZNF136 ZNF263 ZNF317 ZNF394 ZNF398 ZNF436 ZNF440 ZNF473 ZNF491 ZNF558 ZNF764 ZNF768 ZNF837 ZRSR2 ZSCAN21	8 interacting genes: APP CCNL1 CEP350 CLK2 CLK3 PRMT5 SRPK1 SRPK2
Entrez ID		1196	57035
HPRD ID		04289	14835
Ensembl ID		ENSG00000176444	ENSG00000117616
Uniprot IDs		A8K7I0 B1AVT0 B7Z8N6 P49760	Q9BUV0
PDB IDs		3NR9 5UNP 6FYI 6FYK 6FYL 6KHE
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Processing RNA Splicing MRNA Splicing, Via Spliceosome RNA Binding RNA Splicing, Via Transesterification Reactions RS Domain Binding RNA Processing Nucleus RNA Metabolic Process Nuclear Speck Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleic Acid Metabolic Process Regulation Of MRNA Metabolic Process Spliceosomal Complex Regulation Of RNA Metabolic Process Zinc Ion Binding Protein-RNA Complex Assembly Nucleic Acid Binding Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Binding Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splice Site Recognition Macromolecule Metabolic Process Catalytic Step 2 Spliceosome Regulation Of Metabolic Process Spliceosomal Complex Assembly Mammalian Oogenesis Stage Protein Binding MRNA Alternative Polyadenylation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein K6-linked Ubiquitination Protein Serine/threonine/tyrosine Kinase Activity Pre-mRNA 3'-splice Site Binding U2AF Complex MRNA 3'-end Processing RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Positive Regulation Of Translational Initiation Regulation Of Transcription By RNA Polymerase II Negative Regulation Of PERK-mediated Unfolded Protein Response N6-methyladenosine-containing RNA Reader Activity	Regulation Of RNA Splicing Nuclear Speck Phosphorylation Protein Phosphorylation Protein Serine Kinase Activity Regulation Of MRNA Splicing, Via Spliceosome Protein Serine/threonine Kinase Activity Regulation Of MRNA Processing Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein-RNA Complex Assembly Positive Regulation Of Viral Genome Replication Kinase Activity Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Nucleoplasm Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Amyloid-beta Complex Growth Cone Lamellipodium Chromatin Organization Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Nucleus Protein Modification Process Transferase Activity Regulation Of MRNA Metabolic Process Positive Regulation Of Viral Process Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Protein Metabolic Process Regulation Of Viral Genome Replication Negative Regulation Of Viral Process Regulation Of Gene Expression Acetylcholine Receptor Activator Activity Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Regulation Of Cell Cycle Peptidyl-arginine N-methylation PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization
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