CLIC2 and TPRN

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		CLIC2	TPRN
Description		chloride intracellular channel 2	taperin
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Monoatomic Ion Channel Complex Chloride Channel Complex	Nucleus Nucleoplasm Cytoplasm Microvillus Stereocilium Cell Projection Stereocilium Base
	Molecular Function	Glutathione Transferase Activity Glutathione Peroxidase Activity Chloride Channel Activity Protein Binding Oxidoreductase Activity	Actin Binding Protein Phosphatase Inhibitor Activity Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding Phosphatase Binding Protein Phosphatase Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport Signal Transduction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Monoatomic Ion Transmembrane Transport Cellular Oxidant Detoxification Chloride Transmembrane Transport	Sensory Perception Of Sound Auditory Receptor Cell Stereocilium Organization Stereocilium Maintenance
Pathways		Stimuli-sensing channels Ion homeostasis	Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Interacting Genes		5 interacting genes: EP300 NEDD4 NEDD4L TPRN TRAPPC2	9 interacting genes: CLIC1 CLIC2 CLIC4 CLIC5 EPS8 MYO15B PPP1CA PPP1CC WHRN
Entrez ID		1193	286262
HPRD ID		02139	12977
Ensembl ID		ENSG00000155962	ENSG00000176058
Uniprot IDs		O15247	Q4KMQ1
PDB IDs		2PER 2R4V 2R5G	6Y9Q
Enriched GO Terms of Interacting Partners?		Sodium Channel Inhibitor Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Transmembrane Transporter Binding Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Channel Inhibitor Activity Negative Regulation Of Sodium Ion Transport Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transport Neuromuscular Junction Development Receptor Metabolic Process Protein Monoubiquitination Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Neuron Projection Development Receptor Internalization Regulation Of Dendrite Morphogenesis Negative Regulation Of Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transport Cellular Response To UV Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Neuron Projection Development Regulation Of Potassium Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Formation Of Structure Involved In A Symbiotic Process Regulation Of Dendrite Development Negative Regulation Of Monoatomic Ion Transport Cellular Response To Light Stimulus Negative Regulation Of Transmembrane Transport Regulation Of Plasma Membrane Bounded Cell Projection Organization Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Regulation Of Cell Projection Organization Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Regulation Of Nucleocytoplasmic Transport Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Channel Inhibitor Activity Nucleoplasm Positive Regulation Of Intracellular Transport N-terminal Peptidyl-lysine Acetylation	Chloride Channel Complex Chloride Channel Activity Chloride Transmembrane Transport Chloride Transport Inorganic Anion Transmembrane Transport Monoatomic Ion Channel Complex Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Monoatomic Anion Transport Stereocilium PTW/PP1 Phosphatase Complex Stereocilium Bundle Stereocilium Tip Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding Photoperiodism Entrainment Of Circadian Clock Oxidoreductase Activity Inorganic Ion Transmembrane Transport Monoatomic Ion Transmembrane Transport Brush Border Glycogen Metabolic Process Circadian Regulation Of Gene Expression Energy Reserve Metabolic Process Polysaccharide Metabolic Process Phosphatase Activity Monoatomic Ion Transport Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Cerebellar Purkinje Cell Layer Formation Paranodal Junction Maintenance Regulation Of Circadian Rhythm Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Stereocilia Ankle Link USH2 Complex Extracellular Exosome Plasma Membrane Transmembrane Transport Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Termination Of DNA-templated Transcription Dephosphorylation Positive Regulation Of Termination Of RNA Polymerase II Transcription Branching Morphogenesis Of An Epithelial Tube Circadian Rhythm Phosphoprotein Phosphatase Activity Growth Cone Glutamatergic Synapse Dendritic Spine Stereocilia Ankle Link Complex
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