CLCNKA and SLITRK5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLCNKA	SLITRK5
Description		chloride voltage-gated channel Ka	SLIT and NTRK like family member 5
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane Chloride Channel Complex	Plasma Membrane Membrane Receptor Complex Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding Chloride Transmembrane Transporter Activity Identical Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport Transepithelial Chloride Transport Monoatomic Ion Transmembrane Transport Transmembrane Transport Renal Absorption Chloride Transmembrane Transport	Chemical Synaptic Transmission Axonogenesis Grooming Behavior Response To Xenobiotic Stimulus Striatum Development Adult Behavior Skin Development Dendrite Morphogenesis Positive Regulation Of Synapse Assembly Circulatory System Development Synaptic Membrane Adhesion Regulation Of Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission
Pathways		Stimuli-sensing channels	Receptor-type tyrosine-protein phosphatases RAC2 GTPase cycle RAC3 GTPase cycle
Drugs		Niflumic acid Talniflumate
Diseases		Bartter syndrome
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Left ventricular ejection fraction ( 32382064 33495596) Left ventricular end-diastolic volume ( 33495596) Left ventricular end-systolic volume ( 33495596) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Waist circumference adjusted for body mass index ( 28552196)	Male sexual orientation ( 29217827) Metabolite levels ( 23823483) Mild influenza (H1N1) infection ( 26379185)
Interacting Genes		22 interacting genes: CYSRT1 IKZF3 KLHL20 KPRP KRT31 KRT34 KRT37 KRT39 KRTAP21-2 KRTAP4-12 KRTAP6-3 LHX3 MBD3L1 PBX4 SLITRK5 SPMIP4 SRPK2 TCF12 TCF4 TEPSIN TRIB3 ZNF511	3 interacting genes: BOLA2 BOLA2B CLCNKA
Entrez ID		1187	26050
HPRD ID		03608	18065
Ensembl ID		ENSG00000186510	ENSG00000165300
Uniprot IDs		P51800	O94991
PDB IDs		2PFI
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Epidermis Development Structural Molecule Activity Epithelial Cell Differentiation Morphogenesis Of An Epithelium Establishment Of Skin Barrier DNA-binding Transcription Factor Activity Type II Interferon Binding Coated Vesicle Membrane Skin Epidermis Development Cellular Developmental Process Tissue Morphogenesis Cell Differentiation Anatomical Structure Morphogenesis Tissue Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Skin Development E-box Binding Medial Motor Column Neuron Differentiation Prolactin Secreting Cell Differentiation Regulation Of Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Protein K33-linked Ubiquitination	Iron-sulfur Cluster Assembly Complex [2Fe-2S] Cluster Assembly 2 Iron, 2 Sulfur Cluster Binding Iron-sulfur Cluster Assembly Cell Redox Homeostasis Intracellular Iron Ion Homeostasis Iron-sulfur Cluster Binding Protein Maturation Transepithelial Chloride Transport Voltage-gated Chloride Channel Activity Inorganic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Intracellular Chemical Homeostasis Chloride Transmembrane Transporter Activity Cellular Homeostasis Transepithelial Transport Renal Absorption Chemical Homeostasis Chloride Channel Complex Chloride Channel Activity Homeostatic Process Chloride Transmembrane Transport Chloride Transport Inorganic Anion Transmembrane Transport Renal System Process Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Monoatomic Anion Transport
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