UBE2J2 and HERC4

Number of citations of the paper that reports this interaction (PubMedID 22496338)
65

Data Source:
BioGRID (pull down)

		UBE2J2	HERC4
Description		ubiquitin conjugating enzyme E2 J2	HECT and RLD domain containing E3 ubiquitin protein ligase 4
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane	Fibrillar Center Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Response To Unfolded Protein Protein Ubiquitination ERAD Pathway Protein K6-linked Ubiquitination Positive Regulation Of Protein Targeting To Mitochondrion	Ubiquitin-dependent Protein Catabolic Process Spermatogenesis Protein Ubiquitination Cell Differentiation Negative Regulation Of Smoothened Signaling Pathway
Pathways		E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 28067908) Systemic lupus erythematosus ( 28714469) Ulcerative colitis ( 28067908)	Appendicular lean mass ( 33097823) Body mass index ( 28892062)
Interacting Genes		23 interacting genes: AQP6 ATP13A2 ELOVL7 FBXO7 HECW1 HERC4 ITCH MARCHF6 MDM2 MGRN1 NEDD4L PRKN PUSL1 RBP1 RNF10 TMEM14B TRIM25 TRIM59 UBA1 UBC UBE2G2 WWP2 XIAP	7 interacting genes: HERC6 MAFA UBC UBE2D2 UBE2E3 UBE2J2 UBE2L3
Entrez ID		118424	26091
HPRD ID		15600	13646
Ensembl ID		ENSG00000160087	ENSG00000148634
Uniprot IDs		A6NGS0 Q8N2K1	Q5GLZ8
PDB IDs		2F4W
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Macromolecule Catabolic Process Protein Modification Process Proteolysis Catabolic Process Protein K48-linked Ubiquitination Protein Monoubiquitination Proteasomal Protein Catabolic Process Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Protein Metabolic Process Protein Autoubiquitination Macromolecule Metabolic Process Positive Regulation Of Protein Linear Polyubiquitination Protein K63-linked Ubiquitination Negative Regulation Of Signal Transduction ERAD Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Ubiquitin Ligase Complex Ligase Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Autophagy Of Mitochondrion Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Manganese Ion Potassium Channel Inhibitor Activity Response To Oxidative Stress Protein K29-linked Ubiquitination Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Protein Catabolic Process Regulation Of Protein Localization Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Manganese Ion Positive Regulation Of Protein Catabolic Process Cellular Response To Oxidative Stress Negative Regulation Of Protein Localization Regulation Of Protein Transport Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Polyubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Exosomal Secretion	Ubiquitin Conjugating Enzyme Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Polyubiquitination Protein Modification Process Macromolecule Catabolic Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein K11-linked Ubiquitination Protein Metabolic Process Regulation Of Protein Targeting To Mitochondrion Ubiquitin Protein Ligase Binding Transferase Activity Catabolic Process Protein K48-linked Ubiquitination Ubiquitin Ligase Complex ATP Binding Macromolecule Metabolic Process Nucleotide Binding Ubiquitin-protein Transferase Activator Activity Cytosol Protein Tag Activity Positive Regulation Of Establishment Of Protein Localization Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Activity Nucleoplasm
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