CLCN5 and CXCR4

		CLCN5	CXCR4
Description		chloride voltage-gated channel 5	C-X-C motif chemokine receptor 4
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GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Endosome Early Endosome Golgi Apparatus Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Apical Part Of Cell	Cytoplasm Lysosome Endosome Early Endosome Late Endosome Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cell Leading Edge Cytoplasmic Vesicle Protein-containing Complex Extracellular Exosome Anchoring Junction
	Molecular Function	Nucleotide Binding Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity Identical Protein Binding	Virus Receptor Activity Actin Binding G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Cytokine Binding C-C Chemokine Binding Ubiquitin Protein Ligase Binding Myosin Light Chain Binding C-X-C Motif Chemokine 12 Receptor Activity Ubiquitin Binding
	Biological Process	Renal System Process Monoatomic Ion Transport Chloride Transport Endocytosis Monoatomic Ion Transmembrane Transport Transmembrane Transport Chloride Transmembrane Transport	Response To Hypoxia Dendritic Cell Chemotaxis Apoptotic Process Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Brain Development Response To Virus Cell Migration Calcium-mediated Signaling Neurogenesis Regulation Of Cell Adhesion Regulation Of Cell Migration Positive Regulation Of Cell Migration CXCL12-activated CXCR4 Signaling Pathway Myelin Maintenance Symbiont Entry Into Host Cell Positive Regulation Of Oligodendrocyte Differentiation Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Vasculature Development Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway
Pathways		Stimuli-sensing channels	Binding and entry of HIV virion Signaling by ROBO receptors Chemokine receptors bind chemokines G alpha (i) signalling events Formation of definitive endoderm Specification of primordial germ cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs			Baclofen Framycetin AMD-070 Plerixafor Ulocuplumab Ibalizumab MSX-122
Diseases		Dent disease, including: Dent disease 1; Dent disease 2; X-linked recessive nephrolithiasis ; Hypophosphatemic rickets; Low-molecular-weight proteinuria with hypercalciuria and nephrocalcinosis	Chemokine receptor defect, including the following disease: WHIM syndrome
GWAS		Height ( 28552196) Hip circumference adjusted for BMI ( 28552196) Red blood cell count ( 32888494)	Albumin-globulin ratio ( 29403010) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arthritis (juvenile idiopathic) ( 27005825) Attention deficit hyperactivity disorder ( 32595297) Body mass index ( 26426971) Colorectal cancer ( 29228715) Estimated glomerular filtration rate ( 31152163) Lung function (low FEV1 vs high FEV1) ( 26423011) Monocyte count ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 19525953 31604244) Non-albumin protein levels ( 29403010) Smoking status (ever vs never smokers) ( 30643258) Telomere length ( 20421499) White blood cell count ( 32888494)
Interacting Genes		5 interacting genes: CFL1 CXCR4 MAGI1 WWP1 WWP2	43 interacting genes: ACAT1 AGO3 ARRB2 ATP13A2 B2M CCR5 CD4 CDRT15P3 CLCN5 COL4A1 CTSG CXCL12 DHX57 DPP4 DUXAP9 ELANE FTO GNA13 GNAI1 GRK3 HSPA8 ITCH JAK1 JAK2 JAK3 MYBL2 MYH9 PTK2 PTPN11 PTPN6 PTPRC RALB RNF113A SCAMP2 SDC4 SOCS1 SOCS3 STAT1 STAT2 STAT3 STAT5B USP14 VAV1
Entrez ID		1184	7852
HPRD ID		02053	01217
Ensembl ID		ENSG00000171365	ENSG00000121966
Uniprot IDs		A8K4H5 B3KRR2 P51795 V9GYG7	A0A0U3FJG0 A0A0U3GXA9 A0A8Q3WLL1 P61073
PDB IDs		2J9L 2JA3	2K03 2K04 2K05 2N55 3ODU 3OE0 3OE6 3OE8 3OE9 4RWS 8GP3 8I0Q 8K3Z 8U4N 8U4O 8U4P 8U4Q 8U4R 8U4S 8U4T 8YU7 8ZPL 8ZPM 8ZPN
Enriched GO Terms of Interacting Partners?		Symbiont Entry Into Host Cell Biological Process Involved In Interaction With Host Cofilin-actin Rod Cell Leading Edge Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Positive Regulation Of Barbed-end Actin Filament Capping Positive Regulation Of Protein Localization To Cell Leading Edge C-X-C Motif Chemokine 12 Receptor Activity Anchoring Junction Ubiquitin Ligase Complex Negative Regulation Of Postsynaptic Density Organization Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Protein Localization To Cell Leading Edge Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Cell Adhesion Extracellular Exosome Neural Fold Formation Actin Filament Fragmentation Negative Regulation Of Dendritic Spine Maintenance Regulation Of Barbed-end Actin Filament Capping Cell-cell Junction Negative Regulation Of Lamellipodium Assembly CXCL12-activated CXCR4 Signaling Pathway Negative Regulation Of Potassium Ion Export Across Plasma Membrane Myosin Light Chain Binding C-X-C Chemokine Receptor CXCR4 Signaling Pathway Ubiquitin-protein Transferase Activity Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway C-X-C Chemokine Receptor Activity Negative Regulation Of Cell Size Positive Regulation Of Synaptic Plasticity Potassium Channel Inhibitor Activity Positive Regulation Of Actin Filament Depolymerization Cellular Response To Insulin-like Growth Factor Stimulus Cellular Response To Ether Actin Filament Depolymerization Modification Of Postsynaptic Actin Cytoskeleton Phosphatidylinositol Bisphosphate Binding Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Dendritic Spine Maintenance Actin Filament Severing Endothelial Cell Morphogenesis Ubiquitin Protein Ligase Activity Morphogenesis Of An Epithelial Fold Myelin Maintenance Alpha-actinin Binding Actin Binding Cellular Response To Interleukin-6 Response To Virus	Regulation Of Cell-cell Adhesion Cytokine-mediated Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Immune System Process Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Via STAT Regulation Of T Cell Activation Positive Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Growth Hormone Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Adhesion Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Activation Regulation Of Defense Response Positive Regulation Of T Cell Activation Response To Stress Defense Response Positive Regulation Of Immune System Process Interleukin-9-mediated Signaling Pathway Negative Regulation Of Immune System Process Positive Regulation Of Multicellular Organismal Process Response To Other Organism Cell Activation Immune System Process Negative Regulation Of Leukocyte Cell-cell Adhesion Response To External Biotic Stimulus Regulation Of Cytokine Production Interleukin-15-mediated Signaling Pathway Leukocyte Activation Positive Regulation Of Lymphocyte Activation Regulation Of T Cell Proliferation Cell Migration Regulation Of Leukocyte Proliferation Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Population Proliferation Negative Regulation Of Leukocyte Activation Positive Regulation Of Cell Activation Leukocyte Mediated Cytotoxicity T Cell Activation Negative Regulation Of T Cell Activation Positive Regulation Of Immune Response Regulation Of Developmental Process Interleukin-6-mediated Signaling Pathway Regulation Of Multicellular Organismal Process
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