AP2M1 and ATG9A

Number of citations of the paper that reports this interaction (PubMedID 37219487)
66

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		AP2M1	ATG9A
Description		adaptor related protein complex 2 subunit mu 1	autophagy related 9A
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GO Annotations	Cellular Component	Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Membrane AP-2 Adaptor Complex Clathrin Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Synapse Clathrin-coated Endocytic Vesicle Extracellular Exosome Postsynapse Extrinsic Component Of Presynaptic Endocytic Zone Membrane Glutamatergic Synapse	Golgi Membrane Phagophore Assembly Site Autophagosome Membrane Cytoplasm Mitochondrion Endosome Late Endosome Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Membrane Cytoplasmic Vesicle Late Endosome Membrane Mitochondrial Membrane Phagophore Assembly Site Membrane Recycling Endosome Recycling Endosome Membrane Synaptic Membrane
	Molecular Function	Signal Sequence Binding Protein Binding Lipid Binding Clathrin Adaptor Activity Transmembrane Transporter Binding Low-density Lipoprotein Particle Receptor Binding Disordered Domain Specific Binding	Protein Binding Phospholipid Scramblase Activity
	Biological Process	Positive Regulation Of Receptor Internalization Intracellular Protein Transport Endocytosis Vesicle Budding From Membrane Protein Transport Vesicle-mediated Transport Receptor Internalization Synaptic Vesicle Endocytosis Protein-containing Complex Assembly Clathrin-dependent Endocytosis Regulation Of Vesicle Size Postsynaptic Neurotransmitter Receptor Internalization Vesicle-mediated Transport In Synapse Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Protein Localization To Plasma Membrane	Autophagosome Assembly Mitophagy Lipid Transport Autophagy Negative Regulation Of Macrophage Cytokine Production Plasma Membrane Phospholipid Scrambling Negative Regulation Of Interferon-beta Production Protein Localization To Golgi Apparatus Protein Localization To Phagophore Assembly Site Piecemeal Microautophagy Of The Nucleus Innate Immune Response Bone Morphogenesis Reticulophagy Programmed Necrotic Cell Death
Pathways		Nef mediated downregulation of CD28 cell surface expression Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS	Macroautophagy PINK1-PRKN Mediated Mitophagy
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)
Interacting Genes		96 interacting genes: ADRA1B AGTR1 AP2B1 AQP4 ARRB2 ATG9A ATXN1L BDKRB2 C1orf35 CACNA1A CD22 CD2BP2 CD3D CDK11B CEBPA CKS1B CLK2 CORO7 CRIP1 CSNK2B CTLA4 CXorf51A CXorf51B DAB2 DCX DNAJB11 DPPA2 DVL2 EAF1 EHD2 EIF1AD EIF4G1 ETV5 FAM90A1 FGF12 FURIN FXR2 GAK GRIN2A GRIN2B H2BC10 H2BC13 H2BC21 H2BC4 H2BC6 H2BC7 H2BC8 HEXIM2 HOOK2 HTR6 IKZF1 IL1RAP IRS2 JADE1 KCNJ11 KNOP1 LAMP1 LPP LTB4R2 LUC7L2 LY9 MAB21L3 MED4 MEGF10 MFAP1 MPP1 MTURN NAA11 NCOR2 NDRG1 NKAPD1 PRPF18 PRPF38A PRR13 PTS RALBP1 RNF111 RPL22 RPL38 RRP12 RSPH14 RUNDC3A SFRP4 SNCA SPATS2 STON2 SYNJ1 TASOR TBC1D5 TGOLN2 TIAM1 TMA16 UBC XPA ZBTB8A ZNF581	49 interacting genes: ADAMTSL4 ANKRD10 AP2M1 CERCAM CFAP68 CHPF CIB4 CYSRT1 ETHE1 HDHD3 KLHL20 KPRP KRT31 KRT33B KRT34 KRT35 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP11-1 KRTAP13-3 KRTAP19-1 KRTAP3-2 KRTAP3-3 KRTAP4-2 KRTAP5-9 KRTAP6-2 KRTAP8-1 KRTAP9-2 LONRF1 MAPK6 MEOX1 MEOX2 MGAT5B NBPF19 NDUFB7 NOTCH2NLA OXER1 REL SRC SRCAP TBK1 TCF4 TRIM42 UBE3A YPEL3 ZBTB42 ZNF581 ZNF620
Entrez ID		1173	79065
HPRD ID		03014	07979
Ensembl ID		ENSG00000161203	ENSG00000198925
Uniprot IDs		B4DNB9 E9PFW3 Q96CW1	Q7Z3C6
PDB IDs		1H6E 6BNT 6URI	6WQZ 6WR4 7JLO 7JLP 7JLQ 8KBZ 8KC3 8Y1L
Enriched GO Terms of Interacting Partners?		Innate Immune Response In Mucosa Mucosal Immune Response Organ Or Tissue Specific Immune Response Protein-containing Complex Organization Protein-containing Complex Assembly Protein Heterodimerization Activity Structural Constituent Of Chromatin Antibacterial Humoral Response Nucleosome Assembly Protein Domain Specific Binding Nucleosome Nucleosome Organization Protein-DNA Complex Assembly AP-2 Adaptor Complex Import Into Cell Endocytosis Receptor-mediated Endocytosis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Defense Response To Gram-positive Bacterium Synaptic Vesicle Endocytosis Synaptic Vesicle Uncoating Presynaptic Endocytosis Trans-synaptic Signaling Clathrin Adaptor Activity Synaptic Signaling Clathrin Coat Assembly Nucleoplasm Positive Regulation Of Receptor-mediated Endocytosis Clathrin-coated Endocytic Vesicle Antimicrobial Humoral Response Positive Regulation Of Endocytosis Clathrin Coat Disassembly Regulation Of Neuronal Synaptic Plasticity Regulation Of Endocytosis Chemical Synaptic Transmission Excitatory Postsynaptic Potential Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Vesicle Uncoating Nucleus Positive Regulation Of Receptor Internalization Synaptic Membrane Protein Binding Cellular Component Assembly NMDA Glutamate Receptor Activity Synapse Clathrin-dependent Endocytosis Synaptic Vesicle Regulation Of Vesicle-mediated Transport NMDA Selective Glutamate Receptor Complex	Intermediate Filament Keratin Filament Structural Constituent Of Skin Epidermis Structural Molecule Activity Epidermis Development Intermediate Filament Organization Somite Specification Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process
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