LEAP2 and GHSR

Number of citations of the paper that reports this interaction (PubMedID 32803260)
0

Data Source:
BioGRID (pull down)

		LEAP2	GHSR
Description		liver enriched antimicrobial peptide 2	growth hormone secretagogue receptor
Image
GO Annotations	Cellular Component	Extracellular Region	Plasma Membrane Cell Surface Membrane Neuron Projection Membrane Raft Synaptic Membrane Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse
	Molecular Function		Growth Hormone Secretagogue Receptor Activity G Protein-coupled Receptor Activity Protein Binding Growth Hormone-releasing Hormone Receptor Activity Peptide Hormone Binding Hormone Binding Identical Protein Binding
	Biological Process	Defense Response To Bacterium Defense Response To Fungus Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	G Protein-coupled Receptor Internalization Signal Transduction G Protein-coupled Receptor Signaling Pathway Spermatogenesis Female Pregnancy Learning Or Memory Actin Polymerization Or Depolymerization Adult Feeding Behavior Response To Hormone Hormone-mediated Signaling Pathway Negative Regulation Of Norepinephrine Secretion Peptide Hormone Secretion Growth Hormone Secretion Response To Food Negative Regulation Of Appetite Positive Regulation Of Appetite Response To Follicle-stimulating Hormone Response To Estradiol Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Ghrelin Secretion Positive Regulation Of Multicellular Organism Growth Regulation Of Hindgut Contraction Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Growth Negative Regulation Of Insulin Secretion Decidualization Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Regulation Of Synapse Assembly Regulation Of Transmission Of Nerve Impulse Regulation Of Growth Hormone Secretion Regulation Of Feeding Behavior Response To Growth Hormone Cellular Response To Lipopolysaccharide Response To Dexamethasone Negative Regulation Of Locomotion Involved In Locomotory Behavior Cellular Response To Thyroid Hormone Stimulus Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Organization Positive Regulation Of Small Intestinal Transit Response To L-glutamate Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Eating Behavior Positive Regulation Of Small Intestine Smooth Muscle Contraction Regulation Of Gastric Motility Positive Regulation Of Vascular Endothelial Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Macrophage Apoptotic Process
Pathways		Antimicrobial peptides	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs			Ulimorelin Macimorelin Echinacoside
Diseases
GWAS		Asthma ( 31619474) Blood protein levels ( 30072576)	Appendicular lean mass ( 33097823) Chronotype ( 30696823) Cocaine dependence ( 31212010) Height ( 20881960 23563607 25282103 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483)
Interacting Genes		1 interacting genes: GHSR	5 interacting genes: CORT DRD1 GHRL LEAP2 SIGMAR1
Entrez ID		116842	2693
HPRD ID		17269	03541
Ensembl ID		ENSG00000164406	ENSG00000121853
Uniprot IDs		Q969E1	Q92847
PDB IDs		2L1Q	6KO5 7F9Y 7F9Z 7NA7 7NA8 7W2Z 8JSR
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Locomotion Involved In Locomotory Behavior Regulation Of Hindgut Contraction Positive Regulation Of Eating Behavior Regulation Of Gastric Motility Positive Regulation Of Response To Food Positive Regulation Of Appetite Positive Regulation Of Small Intestinal Transit Growth Hormone-releasing Hormone Receptor Activity Growth Hormone Secretagogue Receptor Activity Ghrelin Secretion Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Norepinephrine Secretion Growth Hormone Secretion Negative Regulation Of Macrophage Apoptotic Process Regulation Of Norepinephrine Secretion Cellular Response To Thyroid Hormone Stimulus Negative Regulation Of Catecholamine Secretion Negative Regulation Of Appetite Regulation Of Eating Behavior Positive Regulation Of Digestive System Process Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Response To Insulin-like Growth Factor Stimulus Adult Feeding Behavior Positive Regulation Of Feeding Behavior Regulation Of Growth Hormone Secretion G Protein-coupled Receptor Internalization Response To Growth Hormone Response To Follicle-stimulating Hormone Hormone Binding Regulation Of Response To Food Regulation Of Transmission Of Nerve Impulse Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Response To L-glutamate Positive Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of Myeloid Cell Apoptotic Process Response To Thyroid Hormone Decidualization Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Appetite Regulation Of Protein Localization To Synapse Positive Regulation Of Sprouting Angiogenesis Regulation Of Feeding Behavior Positive Regulation Of Behavior Positive Regulation Of Smooth Muscle Contraction Response To Gonadotropin Regulation Of Receptor Localization To Synapse Response To Food Postsynaptic Modulation Of Chemical Synaptic Transmission	G Protein-coupled Receptor Signaling Pathway Hormone Activity G Protein-coupled Receptor Binding Habituation Conditioned Taste Aversion Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs Operant Conditioning Sensitization G Protein-coupled Receptor Complex Synapse Assembly Glutamatergic Synapse Feeding Behavior Organic Hydroxy Compound Transport Adult Behavior Regulation Of Postsynapse Organization Regulation Of Synapse Assembly Positive Regulation Of Eating Behavior Positive Regulation Of Cortisol Secretion Ghrelin Receptor Binding Positive Regulation Of Response To Food Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Appetite Growth Hormone-releasing Hormone Activity Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Cortisol Secretion Positive Regulation Of Small Intestinal Transit Positive Regulation Of Growth Rate Positive Regulation Of Small Intestine Smooth Muscle Contraction Regulation Of Gastric Motility Positive Regulation Of Bone Development Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Gastric Mucosal Blood Circulation Synapse Dopamine Neurotransmitter Receptor Activity Neuronal Dense Core Vesicle Lumen Regulation Of Growth Rate Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Regulation Of Locomotion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Heterotrimeric G-protein Binding Interneuron Migration From The Subpallium To The Cortex Cell Junction Assembly Dopamine Binding Nonassociative Learning Phospholipase C-activating Dopamine Receptor Signaling Pathway Cerebral Cortex GABAergic Interneuron Migration Synapse Organization
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