CKS1B and ROPN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CKS1B	ROPN1
Description		CDC28 protein kinase regulatory subunit 1B	rhophilin associated tail protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleoplasm SCF Ubiquitin Ligase Complex	Nucleus Cytoplasm Cilium Motile Cilium Cell Projection
	Molecular Function	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Histone Binding Ubiquitin Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Mitotic Cell Cycle Cell Division	Flagellated Sperm Motility Cilium Organization Sperm Capacitation Protein Localization To Cilium
Pathways		SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1	RHO GTPases Activate Rhotekin and Rhophilins
Drugs		Fluoxetine 2,8-bis[oxido(oxo)vanadio]-1,1,1,3,5,5,7,7,9,9,9-undecaoxopentavanadoxane-2,8-diium
Diseases
GWAS		Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Prostate cancer ( 23535732)	Benign childhood epilepsy with centro-temporal spikes ( 32580138) Household income ( 31844048) Household income (MTAG) ( 31844048)
Interacting Genes		58 interacting genes: AP2M1 ARID5A CBY2 CCDC120 CCNA1 CCNB2 CCNC CDC27 CDC37 CDK2 CDKN1B CDX4 CKS1BP7 CKS2 CT45A1 CUL1 DCDC2 DRC4 DUSP1 ECPAS HSF2BP HSP90AA1 IKZF1 IKZF3 INCA1 KPRP KRTAP10-9 KRTAP5-9 LDHB LHX3 LZTS1 MED12L MEOX1 MEOX2 MIPOL1 NR5A1 PAX5 PAX6 PPP1R13B PSMD9 REL ROPN1 SEPTIN3 SERTAD1 SERTAD2 SKP1 SKP2 SNRNP35 SSBP1 SUMO1P1 TCF12 TCF4 TRIM14 TRIM27 TRIM49C WASF3 XIAP ZBTB9	51 interacting genes: AKAIN1 AKAP14 AKAP3 AKAP5 AKAP7 AP1M1 BTBD16 CDC37 CEP57L1 CKS1B CNST DBF4B ERCC3 FAM110A FAM153A FAM153B FAM161A FAM162A FAM90A1 GNL3L GPKOW HNRNPUL1 KIAA0753 KIF9 LENG1 LMO4 LNX1 LNX2 NTAQ1 PICK1 PKP2 POLR3C PRDM6 PRKAA1 PSMA1 RHPN1 RTP5 SDCBP SERTAD1 SORBS3 SPA17 SPG21 SYTL4 TRIM3 TSGA10IP TSHZ3 TSNAXIP1 TULP3 UBE2W VPS33A XKR3
Entrez ID		1163	54763
HPRD ID		00299	15269
Ensembl ID		ENSG00000173207	ENSG00000065371
Uniprot IDs		P61024 Q5T178	A0A140VKB2 Q9HAT0
PDB IDs		1BUH 1DKS 1DKT 2ASS 2AST 4YC6 7B5L 7B5M 7B5R 7NJ0 8BYA 8BYL 8OR0 8OR4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nucleus Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Identical Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process HMG Box Domain Binding Positive Regulation Of Macromolecule Metabolic Process Cyclin A1-CDK2 Complex Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Cyclin A2-CDK2 Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Protein Serine/threonine Kinase Activity SCF Ubiquitin Ligase Complex Meiosis I Cell Cycle Process Regulation Of Transcription By RNA Polymerase II Somite Specification Cytoplasm Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Cyclin Binding Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Macromolecule Metabolic Process Response To Gonadotropin-releasing Hormone Regulation Of Macromolecule Biosynthetic Process Ubiquitin Ligase Complex Scaffold Activity Meiosis I Protein Polyubiquitination Positive Regulation Of DNA Replication Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription Coregulator Binding Transcription Coactivator Activity	Protein Kinase A Binding Protein Binding Protein Kinase A Regulatory Subunit Binding
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