KLHDC3 and RSPH9

		KLHDC3	RSPH9
Description		kelch domain containing 3	radial spoke head component 9
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GO Annotations	Cellular Component	Chromatin Nucleoplasm Cytoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex	Radial Spoke Radial Spoke Head Cytoplasm Cytoskeleton Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection Kinocilium 9+2 Motile Cilium Radial Spoke Head 1 Radial Spoke Head 3
	Molecular Function	Chromatin Binding Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding
	Biological Process	Reciprocal Meiotic Recombination Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Meiotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway	Cilium Movement Cell Projection Organization Axoneme Assembly Motile Cilium Assembly Cilium Movement Involved In Cell Motility Radial Spoke Assembly Axonemal Central Apparatus Assembly
Pathways		XBP1(S) activates chaperone genes
Drugs
Diseases			Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS			Intracranial aneurysm ( 29531279) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		5 interacting genes: DRC5 ENAH HLA-DQA1 RSPH9 UBC	11 interacting genes: ADCY10P1 DRC5 HMG20A KLHDC3 LINC03040 LRRC73 OARD1 PNMA1 SPATS1 TAF8 TSPO2
Entrez ID		116138	221421
HPRD ID		13922	12875
Ensembl ID		ENSG00000124702	ENSG00000172426
Uniprot IDs		Q9BQ90	Q9H1X1
PDB IDs		9D1I 9D1Y 9D1Z	8J07
Enriched GO Terms of Interacting Partners?		Endocytic Vesicle Membrane Sperm Flagellum Cilium Movement Cilium Movement Involved In Cell Motility Radial Spoke Head 1 Radial Spoke Assembly Radial Spoke Head 3 Motile Cilium Axonemal Central Apparatus Assembly Radial Spoke Head Actin Polymerization-dependent Cell Motility Endosome Membrane MHC Class II Receptor Activity Kinocilium Profilin Binding Cell Projection Radial Spoke Peptide Antigen Assembly With MHC Class II Protein Complex Protein Tag Activity MHC Class II Protein Complex Microtubule-based Movement Cytoskeleton Postsynaptic Cytoskeleton Organization WW Domain Binding MHC Class II Protein Complex Binding Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Lumenal Side Of Endoplasmic Reticulum Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II 9+2 Motile Cilium Peptide Antigen Binding Cilium	DNA-templated Transcription Open Complex Formation ADP-ribosyl-[dinitrogen Reductase] Hydrolase Activity 5-aminolevulinic Acid Import Across Plasma Membrane 5-aminolevulinic Acid Transmembrane Transporter Activity
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