UHRF2 and PCNP

Number of citations of the paper that reports this interaction (PubMedID 14741369)
0

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		UHRF2	PCNP
Description		ubiquitin like with PHD and ring finger domains 2	PEST proteolytic signal containing nuclear protein
Image			No pdb structure
GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin	Nucleus Nucleoplasm Nuclear Body
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Histone Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Protein Ligase Activity Histone H3K9me2/3 Reader Activity	Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Protein Sumoylation Cell Differentiation Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of Cell Cycle Protein Autoubiquitination	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		SUMOylation of transcription cofactors
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474 31959851) Asthma or allergic disease (pleiotropy) ( 29785011) Periodontal microbiota ( 22699663)	Height ( 31562340)
Interacting Genes		42 interacting genes: ATR ATXN1 BAX BCAR1 BCL2L1 CCND1 CD27 CDK1 CDK2 CDK4 CDK6 CTNNB1 DESI1 FANCD2 FYN H3C1 HMGB1 HMGB2 JAK3 LCK LYN MCL1 PCNP PTPRC RAD51 RBCK1 RUNX1 SKP1 SMAD4 TP53 TRIM27 TRIM8 UBE2D1 UBE2D2 UBE2D4 UBE2K UBE2W UHRF1 XRCC1 YY1 ZNF410 ZNF618	5 interacting genes: CDC42 CEBPA RBFOX2 TERF2IP UHRF2
Entrez ID		115426	57092
HPRD ID		18257	17826
Ensembl ID		ENSG00000147854	ENSG00000081154
Uniprot IDs		Q96PU4	Q8WW12
PDB IDs		1WY8 1Z6U 2E6S 3OLN 4PW5 4PW6 4PW7 4TVR 5YCO
Enriched GO Terms of Interacting Partners?		DNA Damage Response Response To Gamma Radiation Post-translational Protein Modification Nucleus Regulation Of Apoptotic Process Protein Modification Process Regulation Of Programmed Cell Death Chromosome Organization Lymphocyte Activation Cellular Response To Stress Macromolecule Metabolic Process Regulation Of Metabolic Process Protein Polyubiquitination Protein Ubiquitination Regulation Of Multicellular Organismal Development Negative Regulation Of Metabolic Process Response To Ionizing Radiation DNA Repair Double-strand Break Repair Cell Activation Response To Stress Positive Regulation Of Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Damage Checkpoint Signaling Regulation Of Macromolecule Metabolic Process Regulation Of Hemopoiesis Regulation Of Cell Development Positive Regulation Of Programmed Cell Death Protein Modification By Small Protein Conjugation Leukocyte Activation Intracellular Signal Transduction Regulation Of Primary Metabolic Process Response To Alcohol Signal Transduction Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Macromolecule Metabolic Process Ubiquitin Conjugating Enzyme Activity Regulation Of DNA Metabolic Process Leukocyte Differentiation Condensed Chromosome Regulation Of Apoptotic Signaling Pathway Regulation Of T Cell Activation Response To Xenobiotic Stimulus Transferase Activity T Cell Activation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway	Macrophage Differentiation Intracellular Signal Transduction GBD Domain Binding Storage Vacuole RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Negative Regulation Of DNA Recombination At Telomere Leading Edge Membrane Endothelin Receptor Signaling Pathway Thioesterase Binding Positive Regulation Of Pinocytosis Apolipoprotein A-I Receptor Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Endothelin Receptor Signaling Pathway Involved In Heart Process Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Mononuclear Cell Differentiation Establishment Of Golgi Localization Neuropilin Signaling Pathway Golgi Transport Complex Myeloid Cell Differentiation Regulation Of Cell Cycle Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Myeloid Leukocyte Differentiation Urea Metabolic Process CHOP-C/EBP Complex HMG Box Domain Binding Response To Phenylpropanoid Negative Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Urea Cycle Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Binding White Fat Cell Proliferation STAT Family Protein Binding Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Fat Cell Proliferation Protein Localization To Chromosome, Telomeric Region Nuclear Telomere Cap Complex Protection From Non-homologous End Joining At Telomere Shelterin Complex Telomere Capping G-rich Strand Telomeric DNA Binding Leukocyte Differentiation Positive Regulation Of Pseudopodium Assembly Golgi Localization Cardiac Conduction System Development
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