FCRL3 and SLC30A3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FCRL3	SLC30A3
Description		Fc receptor like 3	solute carrier family 30 member 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Microvillus Membrane Cell Projection	Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Plasma Membrane Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Neuron Projection Synapse Hippocampal Mossy Fiber Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Microvesicle
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Kinase Binding Phosphatase Binding	Zinc Ion Transmembrane Transporter Activity Protein Binding Monoatomic Cation Transmembrane Transporter Activity Antiporter Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Immunoglobulin Production Immune Response Cell Surface Receptor Signaling Pathway Single Fertilization Positive Regulation Of B Cell Proliferation Regulation Of Toll-like Receptor 9 Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of B Cell Differentiation Negative Regulation Of B Cell Receptor Signaling Pathway Regulation Of B Cell Activation Regulation Of Calcium Ion Import	Monoatomic Ion Transport Monoatomic Cation Transport Zinc Ion Transport Response To Zinc Ion Positive Regulation Of Transport Transmembrane Transport Zinc Ion Import Into Organelle Zinc Ion Transmembrane Transport Zinc Ion Import Into Synaptic Vesicle Zinc Ion Import Into Lysosome
Pathways			Zinc efflux and compartmentalization by the SLC30 family
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Graves' disease ( 21841780) IgA nephropathy ( 26028593 32912934) Insulinoma-associated antigen 2 autoantibody levels in type 1 diabetes ( 21829393) Multiple sclerosis ( 21833088 31604244) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Rheumatoid arthritis ( 24390342 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676) Selective IgA deficiency ( 27723758)	Metabolite levels ( 23823483)
Interacting Genes		12 interacting genes: AGPAT4 CMTM5 FCRL1 IGFBP5 MS4A1 PTPN11 PTPN6 SLC2A5 SLC30A3 STATH SYK ZAP70	33 interacting genes: AP3B1 AP3D1 AP3S1 AQP6 CD40 CD79A CGRRF1 CYB5R3 DNAJC5 ELOVL4 FCRL3 FKBP7 GJA8 GOLM1 GPR152 GPR42 GPX8 HSD17B13 LMNA NAALADL2 RETREG3 RNF19B RTN3 SAR1A SCN3B SGPL1 SLC10A6 SLC18A1 SLC30A8 SLC34A2 SLC35H1 TMEM14B TMEM242
Entrez ID		115352	7781
HPRD ID		07352	11924
Ensembl ID		ENSG00000160856	ENSG00000115194
Uniprot IDs		Q96P31	B4DXX8 Q99726
PDB IDs			8XN1
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Neutrophil Activation Involved In Immune Response Leukocyte Activation Neutrophil Activation Beta Selection Cell Activation Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of T Cell Proliferation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Mediated By Integrin B Cell Activation Lymphocyte Activation Negative Regulation Of Neutrophil Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Mononuclear Cell Proliferation Regulation Of Neutrophil Activation Positive Regulation Of T Cell Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Regulation Of Leukocyte Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Immune Response-activating Signaling Pathway T Cell Receptor Complex Myeloid Leukocyte Activation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Cell Adhesion Mediated By Integrin Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Platelet Formation Megakaryocyte Development Positive Regulation Of Alpha-beta T Cell Proliferation Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Leukocyte Activation Involved In Immune Response Cell Activation Involved In Immune Response Regulation Of Lipopolysaccharide-mediated Signaling Pathway T Cell Selection Regulation Of Tumor Necrosis Factor Production Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Developmental Process Regulation Of B Cell Differentiation Positive Regulation Of Cell Adhesion Regulation Of Immune Response Regulation Of Cell Differentiation Regulation Of Cell-cell Adhesion	Membrane Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Vesicle Cargo Loading AP-3 Adaptor Complex Anterograde Synaptic Vesicle Transport Melanosome Assembly Platelet Dense Granule Organization Membrane Coat Positive Regulation Of NK T Cell Differentiation Synaptic Vesicle Transport Synaptic Vesicle Coating Vesicle Coating Melanosome Organization Pigment Granule Organization Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Regulation Of NK T Cell Differentiation Anterograde Axonal Transport Endoplasmic Reticulum Vesicle Transport Along Microtubule Zinc Ion Import Into Organelle Vesicle Cytoskeletal Trafficking Transmembrane Transport Axon Cytoplasm Axonal Transport Secretory Granule Organization Protein Binding Synaptic Vesicle Recycling Axo-dendritic Transport Golgi To Vacuole Transport Organelle Transport Along Microtubule Endoplasmic Reticulum Membrane Endoplasmic Reticulum Tubular Network Organization Inorganic Cation Transmembrane Transport Presynapse Establishment Of Vesicle Localization Zinc Ion Transmembrane Transport Zinc Ion Transport Monoatomic Ion Transport Vesicle Localization Intracellular Zinc Ion Homeostasis Establishment Of Organelle Localization Nitrate Transmembrane Transporter Activity Inorganic Ion Transmembrane Transport Sphinganine-1-phosphate Aldolase Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport
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