CGAS and IRGM

Number of citations of the paper that reports this interaction (PubMedID 32715615)
109

Data Source:
BioGRID (pull down)

		CGAS	IRGM
Description		cyclic GMP-AMP synthase	immunity related GTPase M
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Body Site Of Double-strand Break	Golgi Membrane Autophagosome Membrane Phagocytic Cup Mitochondrion Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Mitochondrial Membrane Cell Projection
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding ATP Binding GTP Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Transferase Activity Nucleotidyltransferase Activity Nucleosome Binding Protein Homodimerization Activity Metal Ion Binding 2',3'-cyclic GMP-AMP Synthase Activity Molecular Condensate Scaffold Activity Poly-ADP-D-ribose Modification-dependent Protein Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Protein Kinase Binding Protein-macromolecule Adaptor Activity Protein Serine/threonine Kinase Activator Activity CARD Domain Binding BH3 Domain Binding Cardiolipin Binding
	Biological Process	Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Defense Response To Virus By Host Immune System Process Regulation Of Immunoglobulin Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway DNA Repair DNA Damage Response Determination Of Adult Lifespan CAMP-mediated Signaling CGMP-mediated Signaling Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Paracrine Signaling Innate Immune Response Negative Regulation Of DNA Repair Regulation Of Immune Response Regulation Of T Cell Activation Defense Response To Virus Cellular Response To Exogenous DsRNA CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Cellular Senescence	Autophagosome Assembly Positive Regulation Of Protein Phosphorylation Immune System Process Autophagy Inflammatory Response Lysosome Organization Positive Regulation Of Autophagy Positive Regulation Of Peptidyl-threonine Phosphorylation Protein Catabolic Process Protein Destabilization Negative Regulation Of Type I Interferon Production Negative Regulation Of Type II Interferon Production Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Interferon-beta Defense Response To Bacterium Positive Regulation Of Macrophage Activation Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein-containing Complex Assembly NLRP3 Inflammasome Complex Assembly Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus Negative Regulation Of Inflammatory Response Protein Stabilization Defense Response To Gram-negative Bacterium Positive Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Protein Complex Stability Protein Lipidation Involved In Autophagosome Assembly CAMKK-AMPK Signaling Cascade Protein-containing Complex Assembly Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Targeting To Vacuole Involved In Autophagy Cellular Response To Lipopolysaccharide Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Mitochondrial Fission Autophagosome Maturation Cellular Response To Virus Antibacterial Innate Immune Response Negative Regulation Of CGAS/STING Signaling Pathway Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Autophagosome Maturation Positive Regulation Of Mitophagy Positive Regulation Of Xenophagy Positive Regulation Of Lysosome Organization
Pathways		STING mediated induction of host immune responses
Drugs
Diseases
GWAS			Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 17554261 17554300 18587394 21102463 28067908) Dimensional psychopathology (Arousal) ( 29496196) Inflammatory bowel disease ( 23128233 28067908)
Interacting Genes		4 interacting genes: IRGM MARCHF8 OTUD3 RNF185	10 interacting genes: ATG10 ATG5 CGAS MAP1LC3C NLRP3 NOD1 NOD2 RIGI SH3GLB1 TLR3
Entrez ID		115004	345611
HPRD ID		12857	19559
Ensembl ID		ENSG00000164430	ENSG00000237693
Uniprot IDs		A0A7P0TBQ3 Q8N884	A1A4Y4
PDB IDs		4KM5 4LEV 4LEW 4MKP 4O67 4O68 4O69 5V8O 5VDO 5VDP 5VDQ 5VDR 5VDS 5VDT 5VDU 5VDV 5VDW 6CT9 6CTA 6EDB 6EDC 6LRC 6LRE 6LRI 6LRJ 6LRK 6LRL 6MJU 6MJW 6MJX 6NAO 6NFG 6NFO 6O47 6Y5D 6Y5E 7C0M 7CCQ 7CCR 7FTF 7FTG 7FTH 7FTI 7FTJ 7FTK 7FTL 7FTM 7FTN 7FTO 7FTP 7FTQ 7FTR 7FTS 7FTT 7FTU 7FTV 7FTW 7FTX 7FTY 7FTZ 7FU0 7FU1 7FU2 7FU3 7FU4 7FU5 7FU6 7FU7 7FU8 7FU9 7FUA 7FUB 7FUC 7FUD 7FUE 7FUF 7FUG 7FUH 7FUI 7FUJ 7FUK 7FUL 7FUM 7FUN 7FUO 7FUP 7FUQ 7FUR 8IME 8IMF 8IMG 8OKX 8OL1 8SHZ 8SI0 8SJ8 8WR8 9C3G 9ELX 9MDC 9MDD
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Lipidation Involved In Autophagosome Assembly Protein K6-linked Deubiquitination Protein K27-linked Deubiquitination Protein Metabolic Process Innate Immune Response-activating Signaling Pathway Endoplasmic Reticulum Membrane Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Regulation Of Cytokine-mediated Signaling Pathway Late Endosome Membrane Positive Regulation Of Lysosome Organization C-terminal Protein Lipidation Protein Stabilization Protein Polyubiquitination Immune Response Autophagy Ubiquitin-like Protein Conjugating Enzyme Binding Positive Regulation Of Innate Immune Response Intracellular Receptor Signaling Pathway Ubiquitin-protein Transferase Activity MHC Protein Binding Positive Regulation Of Xenophagy Positive Regulation Of Response To Type II Interferon Positive Regulation Of Type II Interferon-mediated Signaling Pathway Positive Regulation Of Autophagosome Maturation BH3 Domain Binding CAMKK-AMPK Signaling Cascade Positive Regulation Of Peptidyl-threonine Phosphorylation Ubiquitin Protein Ligase Activity Immune Response-activating Signaling Pathway Protein K11-linked Deubiquitination Regulation Of Protein Stability Protein Alpha-1,2-demannosylation Regulation Of Innate Immune Response Response To Virus Immune Response-regulating Signaling Pathway Endoplasmic Reticulum Mannose Trimming Protein K27-linked Ubiquitination Activation Of Immune Response Lysosomal Membrane Regulation Of Protein Complex Stability Negative Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Lysosome Organization Protein Targeting To Vacuole Involved In Autophagy Regulation Of Type II Interferon-mediated Signaling Pathway	Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of Cytokine Production Involved In Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Cytokine Production Involved In Immune Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Pattern Recognition Receptor Activity Autophagy Positive Regulation Of Innate Immune Response Innate Immune Response Immune Response-activating Signaling Pathway Defense Response To Symbiont Positive Regulation Of Interleukin-8 Production Immune Response-regulating Signaling Pathway Defense Response To Other Organism Response To Stress Activation Of Immune Response Regulation Of Cytokine Production Regulation Of Defense Response Positive Regulation Of Defense Response Cellular Response To Exogenous DsRNA Regulation Of Dendritic Cell Cytokine Production Intracellular Receptor Signaling Pathway Peptidoglycan Binding Positive Regulation Of Cytokine Production Regulation Of Interleukin-8 Production Regulation Of Immune Response Cellular Response To DsRNA Positive Regulation Of Interleukin-6 Production Positive Regulation Of Immune Effector Process Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Response To Other Organism Positive Regulation Of Immune Response Detection Of Biotic Stimulus Regulation Of Type I Interferon Production Immune Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Regulation Of Interleukin-6 Production Response To Exogenous DsRNA Response To Virus Response To External Biotic Stimulus Macroautophagy Defense Response Detection Of Virus Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Autophagy
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