GPRASP2 and MICU2

Number of citations of the paper that reports this interaction (PubMedID 26871637)
43

Data Source:
BioGRID (two hybrid)

		GPRASP2	MICU2
Description		G protein-coupled receptor associated sorting protein 2	mitochondrial calcium uptake 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Calcium Channel Complex Uniplex Complex
	Molecular Function	Amyloid-beta Binding G Protein-coupled Receptor Binding Protein Binding	Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Protein Heterodimerization Activity Calcium Ion Sensor Activity
	Biological Process	Hematopoietic Stem Cell Homeostasis	Mitochondrial Calcium Ion Transmembrane Transport Calcium Import Into The Mitochondrion Mitochondrial Calcium Ion Homeostasis Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Mitochondrial Calcium Ion Concentration Cellular Response To Calcium Ion
Pathways			Mitochondrial calcium ion transport Processing of SMDT1 Mitochondrial protein degradation
Drugs
Diseases
GWAS			Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732)
Interacting Genes		52 interacting genes: ADRB1 ARHGEF6 BARD1 CALCR CAVIN3 CBX8 CCDC146 CEP126 CFAP206 CHRM1 CHRM2 DISC1 DSCR9 EFCAB3 FAM124B FCHSD2 FOXD4L1 FRAT1 GADD45GIP1 HAP1 HRH2 HTR7 HTT LRIF1 MBD3L2 MICU2 MYOT NOL4L-DT PIH1D2 PLAC9 PRPF3 PTN RABGEF1 REX1BD RHPN1 RNF8 RPS6KA5 SAPCD2 SEZ6L SH2D4A SREK1 STMN2 TBRG4 TCF25 TSPOAP1 TTC23 TXN TXN2 USP20 ZC2HC1C ZFYVE26 ZNF688	3 interacting genes: GPRASP2 MBP UBC
Entrez ID		114928	221154
HPRD ID		06612	16852
Ensembl ID		ENSG00000158301	ENSG00000165487
Uniprot IDs		B3KW05 Q96D09	A0A0S2Z6V5 Q8IYU8
PDB IDs			6AGH 6IIH 6K7Y 6LB7 6LB8 6LE5 6WDN 6WDO 6XJV 6XJX 6XQN 6XQO
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Trans-synaptic Signaling G Protein-coupled Acetylcholine Receptor Activity Synaptic Signaling Neuromuscular Synaptic Transmission Regulation Of Protein Export From Nucleus Negative Regulation Of Protein Export From Nucleus Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Microtubule Cytoskeleton Organization Cholinergic Synapse Dendrite	Positive Regulation Of Metalloendopeptidase Activity Regulation Of Metallopeptidase Activity Internode Region Of Axon Compact Myelin Negative Regulation Of Heterotypic Cell-cell Adhesion Structural Constituent Of Myelin Sheath Positive Regulation Of Peptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Multicellular Organismal-level Homeostasis Protein Tag Activity Regulation Of Endopeptidase Activity Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Hematopoietic Stem Cell Homeostasis Myelin Sheath Maintenance Of Blood-brain Barrier
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