MBD6 and ATXN1L

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)

		MBD6	ATXN1L
Description		methyl-CpG binding domain protein 6	ataxin 1 like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Chromosome Chromocenter	Nucleus Nucleoplasm Nucleolus Dendrite Cell Projection
	Molecular Function	DNA Binding Chromatin Binding Protein Binding	DNA Binding Chromatin Binding RNA Binding Protein Binding POZ Domain Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Brain Development Learning Memory Extracellular Matrix Organization Social Behavior Lung Alveolus Development Positive Regulation Of Hematopoietic Stem Cell Proliferation
Pathways		UCH proteinases
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		4 interacting genes: ATXN1L DUSP12 NCK2 RBM10	84 interacting genes: ACO2 ACOT7 ADORA1 AFAP1L2 AGXT ALG13 ANKHD1 AP1G2 AP2M1 APBB1 ARID5A ATXN1 C1orf94 CAMSAP2 CBFA2T2 CDSN CHD6 COIL CTBP1 DAB2 DAZAP2 EPB41L2 EPB41L3 FADS2 FAM168A FOXH1 FUS GAS7 GMEB2 GORASP2 GPATCH8 HGS HIVEP1 HLX HSFX1 KRTAP11-1 KRTAP13-1 KRTAP19-7 KRTAP21-2 KRTAP8-1 LARP4B MACROH2A1 MATN2 MBD1 MBD6 MEIS3 MEOX2 METTL17 METTL27 MYOZ3 NBR1 NCOR1 NCOR2 NIT1 NUTM2F PHPT1 PICALM PICK1 PMFBP1 PRRC2B RAD54L2 RBFOX1 RBFOX2 RRAGC SCAF11 SHISA2 SMARCC2 SPMIP9 SREBF1 ST6GALNAC6 STAC2 SUGP2 TBX2 THY1 TMEM25 TMEM8B TRIP11 UNKL USP54 YPEL3 YY1AP1 ZBTB32 ZC3H7B ZSWIM8
Entrez ID		114785	342371
HPRD ID		11296	19555
Ensembl ID		ENSG00000166987	ENSG00000224470
Uniprot IDs		Q6P0P0 Q96DN6	P0C7T5
PDB IDs
Enriched GO Terms of Interacting Partners?		Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Ribosomal Large Subunit Export From Nucleus Smooth Muscle Cell Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Ribosome Biogenesis Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress POZ Domain Binding Regulation Of Ribosome Biogenesis Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Translation In Response To Stress Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Smooth Muscle Cell Proliferation Signal Complex Assembly Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Cell Population Proliferation Immunological Synapse Formation Dendritic Spine Development Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Hematopoietic Stem Cell Proliferation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Muscle Cell Apoptotic Process Protein Tyrosine/serine/threonine Phosphatase Activity Negative Regulation Of MRNA Splicing, Via Spliceosome 3'-UTR-mediated MRNA Stabilization Cytoskeletal Anchor Activity Regulation Of Translation In Response To Stress Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of RNA Splicing Post-transcriptional Regulation Of Gene Expression MiRNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Biosynthetic Process Signaling Receptor Complex Adaptor Activity Lamellipodium Assembly Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response	Negative Regulation Of Androgen Receptor Signaling Pathway Low-density Lipoprotein Particle Receptor Binding Regulation Of Androgen Receptor Signaling Pathway Axolemma Chromatin Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Clathrin Adaptor Activity Regulation Of Protein Localization To Cell Periphery Transcription Corepressor Activity Clathrin Coat Assembly Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nuclear Body Positive Regulation Of Response To Oxidative Stress Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Extrinsic Component Of Presynaptic Endocytic Zone Membrane Double-stranded Methylated DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of 3'-UTR-mediated MRNA Stabilization Regulation Of Protein Localization Clathrin-coated Pit Clathrin-dependent Endocytosis Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Protein Localization Chromatin Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process
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