CHUK and UBE2N

Number of citations of the paper that reports this interaction (PubMedID 11057907)
0

Data Source:
BioGRID (enzymatic study)

		CHUK	UBE2N
Description		component of inhibitor of nuclear factor kappa B kinase complex	ubiquitin conjugating enzyme E2 N
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol IkappaB Kinase Complex Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Ubiquitin Conjugating Enzyme Complex UBC13-MMS2 Complex Protein-containing Complex Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Kinase Activity Transferase Activity Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity Scaffold Protein Binding Transferrin Receptor Binding	Nucleotide Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activator Activity
	Biological Process	Pattern Recognition Receptor Signaling Pathway Skeletal Muscle Contraction Regulation Of Transcription By RNA Polymerase II Inflammatory Response Immune Response Canonical NF-kappaB Signal Transduction Response To Xenobiotic Stimulus Response To Virus Response To Toxic Substance Anatomical Structure Morphogenesis Response To Acetate Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Interferon-alpha Production Response To Hydroperoxide Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Amino Acid Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Striated Muscle Cell Differentiation Response To Cholecystokinin Cellular Response To Tumor Necrosis Factor Cellular Response To Virus	Protein Polyubiquitination Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Repair Regulation Of DNA Repair Postreplication Repair Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination DNA Damage Response Protein Ubiquitination Cellular Response To Nutrient Levels TORC1 Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Repair T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K63-linked Ubiquitination Antiviral Innate Immune Response Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of TORC1 Signaling Positive Regulation Of Double-strand Break Repair
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 AKT phosphorylates targets in the cytosol Downstream TCR signaling FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Constitutive Signaling by AKT1 E17K in Cancer NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Regulation of NF-kappa B signaling PKR-mediated signaling SLC15A4:TASL-dependent IRF5 activation Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Modulation of host responses by IFN-stimulated genes	ISG15 antiviral mechanism NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PINK1-PRKN Mediated Mitophagy CLEC7A (Dectin-1) signaling Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint E3 ubiquitin ligases ubiquitinate target proteins Interleukin-1 signaling IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 Aggrephagy Aggrephagy SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Aminosalicylic acid Mesalazine Acetylcysteine
Diseases		Cocoon syndrome
GWAS		Liver enzyme levels ( 18940312) Psoriasis ( 28537254) Psoriasis or type 2 diabetes (trans-disease meta-analysis) ( 33385400) Type 2 diabetes ( 30054458)	Height ( 18391951) Mean reticulocyte volume ( 32888494)
Interacting Genes		85 interacting genes: AKT1 AKT2 AMBRA1 ATM ATR BCL10 BCL3 BTRC CASP8 CDC37 CHEK1 CREBBP CSF2RA CSNK2A1 CTNNB1 CUEDC2 CUL1 DCUN1D5 E2F4 EIF2AK2 ELP1 ERBIN ESR1 FKBP5 FOXO3 H3-4 H3C1 H3C14 HECTD3 HSP90AA1 HSP90AB1 HTT IKBKB IKBKE IKBKG IRS1 MAP3K1 MAP3K11 MAP3K14 MAP3K4 MAP3K7 MAP3K8 MYC NCOA3 NCOR1 NCOR2 NFKB1 NFKB2 NFKBIA NFKBIB NLRP4 NOTCH3 NR2C2 PAX8 PEBP1 PIAS1 PRKCB PRKCI PRKCQ PRKDC PTPN11 RELA RICTOR RIPK2 RPL27 SAMHD1 SRC SRPK1 SRPK2 STAP2 TANK TGFBR1 TNFAIP3 TNFRSF1A TP53 TRAF2 TRAF3IP2 TRAF4 TRIM27 TRPC4AP TTC3 UBC UBE2E3 UBE2I UBE2N	124 interacting genes: AMFR ARIH1 ARIH2 ARK2C AURKA BARD1 BCL10 BFAR BIRC2 BIRC3 BIRC8 BRCA1 CADPS2 CBL CCNB1 CHFR CHUK CNOT4 DTL DTX1 DTX3 DZIP3 F12 H2AC4 HERC2 HSP90AA1 LRSAM1 MALT1 MARCHF5 MARCHF7 MDM2 MIB1 MIB2 MID1 MKRN3 MUL1 MYLIP NBN NEDD4L NEURL1 NFX1 OTUB2 PEDS1 PEDS1-UBE2V1 PELI1 PELI3 PJA2 PRKN PTTG1 RBCK1 RBX1 RC3H1 RC3H2 RFFL RFWD3 RIPK1 RNF103 RNF11 RNF111 RNF115 RNF122 RNF125 RNF126 RNF128 RNF13 RNF130 RNF135 RNF152 RNF167 RNF168 RNF181 RNF182 RNF38 RNF4 RNF43 RNF5 RNF8 SH3RF1 SH3RF2 SHPRH SIAH1 SIAH2 SLC2A4 STUB1 TNFAIP3 TOPORS TP53 TRAF2 TRAF6 TREX2 TRIM13 TRIM14 TRIM15 TRIM17 TRIM2 TRIM21 TRIM23 TRIM25 TRIM27 TRIM28 TRIM31 TRIM32 TRIM33 TRIM34 TRIM39 TRIM5 TRIM50 TRIM54 TRIM63 TRIM65 TRIM69 TRIM7 TRIM72 UBA1 UBB UBE2V1 UBE2V2 UBE3A UBE3B UHRF1 XIAP ZNRF2 ZNRF3 ZNRF4
Entrez ID		1147	7334
HPRD ID		02811	04725
Ensembl ID		ENSG00000213341	ENSG00000177889
Uniprot IDs		O15111	P61088 V9HW41
PDB IDs		3BRT 5EBZ 5TQW 5TQX 5TQY	1J7D 2C2V 3HCT 3HCU 3VON 3W31 4DHI 4DHJ 4DHZ 4IP3 4NR3 4NRG 4NRI 4ONL 4ONM 4ONN 4ORH 4TKP 4WHV 5AIT 5AIU 5EYA 5H7S 5VNZ 5VO0 5YWR 6D6I 6JKY 6KFP 6KG6 6KL4 6LP2 6P5B 6S53 6ULH 6UMP 6UMS 7BBD 7BBF 7BXG 9BIV
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Cytosol Nucleoplasm Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Signaling Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Communication Ubiquitin Protein Ligase Binding Negative Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Non-canonical NF-kappaB Signal Transduction Regulation Of Primary Metabolic Process Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Kinase Activity Regulation Of Apoptotic Process Protein Modification Process Protein Serine Kinase Activity Immune System Process Regulation Of Programmed Cell Death Macromolecule Metabolic Process Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Immune System Process Regulation Of Immune Response Nucleus Transferase Activity Protein Metabolic Process Kinase Activity Regulation Of Innate Immune Response Intracellular Signaling Cassette Cytoplasm Negative Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Stress Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Transferase Activity Protein Polyubiquitination Zinc Ion Binding Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Macromolecule Catabolic Process Metal Ion Binding Protein K63-linked Ubiquitination Protein Autoubiquitination Proteolysis Catabolic Process Protein K48-linked Ubiquitination Response To Stress Protein Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Regulation Of Signal Transduction Positive Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Metabolic Process Cellular Response To Stress Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of Signaling Regulation Of Cell Communication Protein Monoubiquitination Immune System Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Defense Response To Symbiont Cytoplasm Defense Response To Other Organism Positive Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Response To Other Organism Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Metabolic Process
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