SCRG1 and NPHP4

		SCRG1	NPHP4
Description		stimulator of chondrogenesis 1	nephrocystin 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Neuron Projection Terminus	Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cell-cell Junction Bicellular Tight Junction Cilium Nuclear Body Photoreceptor Connecting Cilium Ciliary Transition Zone Ciliary Basal Body Cell Projection Anchoring Junction Ribbon Synapse Ciliary Base Non-motile Cilium Photoreceptor Distal Connecting Cilium
	Molecular Function	Protein Binding	Structural Molecule Activity Protein Binding
	Biological Process	Nervous System Development	Signal Transduction Visual Behavior Actin Cytoskeleton Organization Flagellated Sperm Motility Photoreceptor Cell Outer Segment Organization Photoreceptor Cell Maintenance Retina Development In Camera-type Eye Negative Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Positive Regulation Of Bicellular Tight Junction Assembly Protein Localization To Ciliary Transition Zone
Pathways			Signaling by Hippo Anchoring of the basal body to the plasma membrane
Drugs
Diseases			Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Senior-Loken syndrome
GWAS		Chin dimples ( 27182965) Diverticular disease ( 30177863) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Refractive error ( 32231278)	Dimensional psychopathology (Positive) ( 29496196) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) QT interval ( 19305408) Response to taxane treatment (paclitaxel) ( 23006423)
Interacting Genes		6 interacting genes: CATSPER1 CD36 FAM209A MANBAL NPHP4 TMEM14B	8 interacting genes: CIROZ EDIL3 FBXO44 NPHP1 RBP7 RPGRIP1 SCRG1 TMEM201
Entrez ID		11341	261734
HPRD ID		11932	06238
Ensembl ID		ENSG00000164106	ENSG00000131697
Uniprot IDs		O75711 Q6FGG5	B3KW36 O75161
PDB IDs
Enriched GO Terms of Interacting Partners?		Oleate Transmembrane Transporter Activity Regulation Of Removal Of Superoxide Radicals Short-chain Fatty Acid Transport Response To Linoleic Acid Cholesterol Import Toll-like Receptor Binding Lipoteichoic Acid Immune Receptor Activity Long-chain Fatty Acid Import Across Plasma Membrane Thrombospondin Receptor Activity Short-chain Fatty Acid Transmembrane Transporter Activity Lipid Transport Across Blood-brain Barrier Cellular Response To Diacyl Bacterial Lipopeptide Positive Regulation Of Blood Microparticle Formation Oxidised Low-density Lipoprotein Particle Receptor Activity Triglyceride Transport Low-density Lipoprotein Particle Mediated Signaling Oxidised Low-density Lipoprotein Particle Clearance Sperm Motility Cilium Movement Flagellated Sperm Motility Cilium Movement Involved In Cell Motility Cilium-dependent Cell Motility Protein Localization To Ciliary Transition Zone Ribbon Synapse Photoreceptor Distal Connecting Cilium Intestinal Cholesterol Absorption Positive Regulation Of Cholesterol Storage Lipoprotein Particle Binding Cellular Response To Lipoteichoic Acid Regulation Of Response To Reactive Oxygen Species Response To Stilbenoid Nitric Oxide-cGMP-mediated Signaling Amyloid-beta Clearance By Cellular Catabolic Process Cellular Response To Hydroperoxide Long-chain Fatty Acid Import Into Cell Cellular Response To Bacterial Lipopeptide High-density Lipoprotein Particle Binding Calcium-activated Cation Channel Activity CatSper Complex Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Positive Regulation Of Bicellular Tight Junction Assembly Response To Bacterial Lipoprotein Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Intestinal Lipid Absorption Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Phagocytosis, Engulfment Lipid Import Into Cell Phagocytosis, Recognition Photoreceptor Cell Outer Segment Organization Low-density Lipoprotein Particle Receptor Activity	Photoreceptor Connecting Cilium
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