CHRM5 and SLC5A6

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CHRM5	SLC5A6
Description		cholinergic receptor muscarinic 5	solute carrier family 5 member 6
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Synapse Postsynaptic Membrane	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity	Protein Binding Sodium-dependent Multivitamin Transmembrane Transporter Activity Monoatomic Ion Transmembrane Transporter Activity Iodide Transmembrane Transporter Activity Biotin Transmembrane Transporter Activity Pantothenate Transmembrane Transporter Activity Symporter Activity Pantothenate:sodium Symporter Activity Transmembrane Transporter Activity Amide Transmembrane Transporter Activity Vitamin Transmembrane Transporter Activity Monocarboxylate:sodium Symporter Activity Sulfur Compound Transmembrane Transporter Activity
	Biological Process	Gastric Acid Secretion Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Dopamine Transport Transmission Of Nerve Impulse Regulation Of Phosphatidylinositol Dephosphorylation Acetylcholine Receptor Signaling Pathway	Biotin Metabolic Process Monoatomic Ion Transport Sodium Ion Transport Biotin Transport Pantothenate Transmembrane Transport Transmembrane Transport Inorganic Ion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Transport Across Blood-brain Barrier Iodide Transmembrane Transport Biotin Import Across Plasma Membrane
Pathways		Muscarinic acetylcholine receptors G alpha (q) signalling events	Biotin transport and metabolism Vitamin B5 (pantothenate) metabolism Transport of vitamins, nucleosides, and related molecules
Drugs		Ziprasidone Amitriptyline Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Loxapine Meperidine Imipramine Gallamine triethiodide Darifenacin Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Brompheniramine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Promethazine Doxepin Desipramine Ketamine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin ALKS 27 Fesoterodine Methacholine Aclidinium Umeclidinium Dosulepin Etoperidone Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil	Lipoic acid
Diseases
GWAS		Malaria ( 31844061)	Fasting blood glucose adjusted for BMI ( 25625282) Serum metabolite levels ( 33031748)
Interacting Genes		32 interacting genes: ASPH ASTN2 ATP2A2 ATP9A CBFB CD82 EPB41L1 EPC1 ERCC1 GJB6 GOLGA8A GPRASP1 HLA-F MAP3K1 MSMO1 MYH7 NLE1 NPAS3 PRSS16 REEP5 RGS7 RTN1 SCAND2P SLC2A6 SLC5A6 SLC6A8 SMAD6 SNCA SPNS1 STARD3NL TMEM161A USP33	4 interacting genes: CHRM5 ERBIN GALNT6 UBC
Entrez ID		1133	8884
HPRD ID		00331	04934
Ensembl ID		ENSG00000184984	ENSG00000138074
Uniprot IDs		P08912 Q8IVW0	Q9HD19 Q9Y289
PDB IDs		6OL9
Enriched GO Terms of Interacting Partners?		Sarcoplasmic Reticulum Membrane Transition Between Fast And Slow Fiber Negative Regulation Of Exocytosis Sarcoplasmic Reticulum Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Skeletal Muscle Adaptation Supramolecular Fiber Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Transmembrane Transporter Activity Regulation Of Exocytosis Endoplasmic Reticulum Membrane Organization	G Protein-coupled Acetylcholine Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Gastric Acid Secretion Regulation Of Phosphatidylinositol Dephosphorylation Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Hemidesmosome ErbB-2 Class Receptor Binding Basal Protein Localization Negative Regulation Of Monocyte Chemotactic Protein-1 Production Postsynaptic Specialization
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