PTH2 and PTH2R

Number of citations of the paper that reports this interaction (PubMedID 10854439)
0

Data Source:
HPRD (in vitro, in vivo)

		PTH2	PTH2R
Description		parathyroid hormone 2	parathyroid hormone 2 receptor
Image
GO Annotations	Cellular Component	Extracellular Region	Plasma Membrane Membrane
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Parathyroid Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding
	Biological Process	Neuropeptide Signaling Pathway	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis
Pathways		Class B/2 (Secretin family receptors) G alpha (s) signalling events	Class B/2 (Secretin family receptors) G alpha (s) signalling events
Drugs			Parathyroid hormone
Diseases
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anthropometric traits ( 30576415) Hip bone mineral density and total body fat mass (bivariate analysis) ( 32963334) Metabolite levels ( 23823483) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744)
Interacting Genes		1 interacting genes: PTH2R	6 interacting genes: CALM1 DYNLT1 GRHPR HMG20A PTH PTH2
Entrez ID		113091	5746
HPRD ID		16328	03276
Ensembl ID		ENSG00000142538	ENSG00000144407
Uniprot IDs		Q96A98	B4DFN8 P49190
PDB IDs		7F16	7F16
Enriched GO Terms of Interacting Partners?		Parathyroid Hormone Receptor Activity G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Positive Regulation Of Cold-induced Thermogenesis Regulation Of Cold-induced Thermogenesis Transmembrane Signaling Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway	Catalytic Complex Type 1 Parathyroid Hormone Receptor Binding Parathyroid Hormone Receptor Binding Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Hydroxypyruvate Reductase [NAD(P)H] Activity Hydroxypyruvate Reductase (NADH) Activity Glyoxylate Reductase (NADPH) Activity Hydroxypyruvate Reductase (NADPH) Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Intracellular Transport Of Viral Protein In Host Cell Positive Regulation Of Osteoclast Proliferation Negative Regulation Of Apoptotic Process In Bone Marrow Cell Regulation Of Ryanodine-sensitive Calcium-release Channel Activity G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Hormone-mediated Apoptotic Signaling Pathway Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Positive Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Cell Differentiation Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Bone Mineralization Involved In Bone Maturation Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Negative Regulation Of Voltage-gated Calcium Channel Activity Autophagosome Membrane Docking Extracellular Region Spindle Intracellular Transport Of Virus Carboxylic Acid Binding Glyoxylate Metabolic Process Negative Regulation Of Developmental Process Host Cell Secretory Vesicle Negative Regulation Of Protein Sumoylation Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Peptide Hormone Receptor Binding Positive Regulation Of Inositol Phosphate Biosynthetic Process Magnesium Ion Homeostasis Titin Binding Calcium Channel Inhibitor Activity Regulation Of Voltage-gated Calcium Channel Activity Detection Of Calcium Ion Response To Metal Ion Response To Parathyroid Hormone
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