NACC1 and PRPF3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NACC1	PRPF3
Description		nucleus accumbens associated 1	pre-mRNA processing factor 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cell Junction Nuclear Lumen	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Cajal Body Nuclear Speck Protein-containing Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Histone Deacetylase Binding	RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Negative Regulation Of DNA-templated Transcription	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases			Retinitis pigmentosa (RP)
GWAS		Obesity-related traits ( 23251661)	Alanine aminotransferase levels ( 33339817) Ambidextrousness ( 32989287) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 27494321) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Hip index ( 34021172) Low density lipoprotein cholesterol levels ( 30498476) Morning person ( 30696823) Morning vs. evening chronotype ( 27494321) Platelet count ( 32888494 27863252) Plateletcrit ( 27863252) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White blood cell count ( 32888494)
Interacting Genes		20 interacting genes: BCOR C8orf33 CCNB1 EHHADH ELOA HDAC3 HDAC4 LGALS8 LSM3 PML POLR2L PRKCI PRPF18 PRPF3 SENP1 SENP2 TARDBP UBE2I UBTFL1 ZNF512B	50 interacting genes: BRCA1 CARD10 CASK CCDC125 CCDC136 CCDC85B CDC5L CEBPA CEP70 CTNNBL1 DPY30 DVL2 DVL3 FAM9B FCHO1 FRA10AC1 GOLGA2 GPRASP2 GTPBP3 HSF2BP LZTS1 MAPRE1 MID2 NACC1 NAV2 NINL NKAP NKAPD1 OSBPL3 PCBP1 PHC2 PIP4K2B PRPF31 PSMD3 RABEP1 RNF151 SART3 SHKBP1 SNIP1 SNRNP200 SSX2IP TRIM39 TSPYL1 TXLNA USP4 WBP4 ZBTB8A ZCCHC10 ZFPM2 ZGPAT
Entrez ID		112939	9129
HPRD ID		10692	07389
Ensembl ID		ENSG00000160877	ENSG00000117360
Uniprot IDs		Q96RE7	O43395
PDB IDs		3GA1 4U2N 7BV9 8YZS	1X4Q 3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7N2N 7N2R 7N2S 8H6E 8H6J 8H6K 8H6L 8Q7N 8QO9 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y6O
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Nucleoplasm Regulation Of RNA Metabolic Process SUMO Transferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process U4/U6 X U5 Tri-snRNP Complex SUMO-specific Endopeptidase Activity Nucleus DeSUMOylase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Desumoylation Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Gene Expression RNA Metabolic Process Protein Deacetylation Protein Lysine Deacetylase Activity Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Transcription By RNA Polymerase I Negative Regulation Of Myotube Differentiation Histone Deacetylase Activity Negative Regulation Of Macromolecule Metabolic Process PML Body Regulation Of Circadian Rhythm Negative Regulation Of Macromolecule Biosynthetic Process Maintenance Of Protein Location In Nucleus Macromolecule Deacylation Negative Regulation Of Metabolic Process Positive Regulation Of Post-translational Protein Modification Histone Deacetylase Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Presynaptic Cytosol Postsynaptic Cytosol Positive Regulation Of MRNA Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process RNA Splicing Regulation Of Protein Stability Response To DDT Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Interleukin-1 Production Negative Regulation Of Translation In Response To Oxidative Stress Negative Regulation Of Catabolic Process Maintenance Of Protein Localization In Organelle Regulation Of Transcription By RNA Polymerase I SUMO Conjugating Enzyme Activity	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Identical Protein Binding RNA Splicing Spliceosomal Complex U2-type Precatalytic Spliceosome Spliceosomal Tri-snRNP Complex Assembly Nucleus MRNA Processing Hematopoietic Stem Cell Proliferation Nucleoplasm Protein Binding U4 SnRNA Binding Positive Regulation Of Neuron Projection Arborization U4/U6 X U5 Tri-snRNP Complex Spliceosomal SnRNP Assembly Protein-RNA Complex Assembly MRNA Metabolic Process Centrosome Cycle Protein Domain Specific Binding RNA Metabolic Process Prp19 Complex RNA Processing Protein Localization To Microtubule Cytoplasm Protein-containing Complex Assembly Regulation Of Neuron Projection Arborization
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