HOGA1 and CIMAP1A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HOGA1	CIMAP1A
Description		4-hydroxy-2-oxoglutarate aldolase 1	ciliary microtubule associated protein 1A
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Outer Dense Fiber Cytoplasm Cytoskeleton Cilium Motile Cilium Sperm Flagellum Cell Projection
	Molecular Function	Protein Binding (R,S)-4-hydroxy-2-oxoglutarate Aldolase Activity Lyase Activity Protein Homodimerization Activity (4S)-4-hydroxy-2-oxoglutarate Aldolase Activity	Protein Binding
	Biological Process	Glyoxylate Catabolic Process Trans-4-hydroxy-L-proline Catabolic Process Oxalate Metabolic Process Pyruvate Biosynthetic Process Glyoxylate Metabolic Process	Spermatogenesis Cell Differentiation Flagellated Sperm Motility
Pathways		Glyoxylate metabolism and glycine degradation
Drugs
Diseases
GWAS		Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598)
Interacting Genes		1 interacting genes: CIMAP1A	2 interacting genes: DYNLL1 HOGA1
Entrez ID		112817	113746
HPRD ID		12584	16323
Ensembl ID		ENSG00000241935	ENSG00000177947
Uniprot IDs		Q86XE5	Q96PU9
PDB IDs		3S5N 3S5O
Enriched GO Terms of Interacting Partners?		Outer Dense Fiber Sperm Flagellum Sperm Motility Flagellated Sperm Motility Cilium Movement Involved In Cell Motility Cilium-dependent Cell Motility Cilium Movement Motile Cilium	(4S)-4-hydroxy-2-oxoglutarate Aldolase Activity Oxalate Metabolic Process (R,S)-4-hydroxy-2-oxoglutarate Aldolase Activity Deoxyribonuclease Inhibitor Activity Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Glyoxylate Catabolic Process Trans-4-hydroxy-L-proline Catabolic Process Pyruvate Biosynthetic Process Nitric-oxide Synthase Regulator Activity Glyoxylate Metabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Intraciliary Retrograde Transport DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of DNA-templated DNA Replication Aldehyde Catabolic Process Cytoplasmic Dynein Complex Negative Regulation Of DNA Replication Modified Amino Acid Catabolic Process Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus COP9 Signalosome Dynein Intermediate Chain Binding Dynein Complex Microtubule Associated Complex Ciliary Tip Substantia Nigra Development Motile Cilium Assembly Intraciliary Transport Enzyme Inhibitor Activity Ficolin-1-rich Granule Membrane Neural Nucleus Development Regulation Of Nitric Oxide Metabolic Process Axon Cytoplasm Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Nitric Oxide Biosynthetic Process Tertiary Granule Membrane Aldehyde Metabolic Process Pyruvate Metabolic Process Scaffold Protein Binding Mitochondrion L-amino Acid Catabolic Process Positive Regulation Of Insulin Secretion Dicarboxylic Acid Metabolic Process Spermatid Development Site Of Double-strand Break Secretory Granule Amino Acid Catabolic Process Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion
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