SYNRG and ARL6

		SYNRG	ARL6
Description		synergin gamma	ARF like GTPase 6
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Membrane AP-1 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin-coated Vesicle Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Axonemal Microtubule Plasma Membrane Cilium Axoneme Microtubule Cytoskeleton Membrane Membrane Coat Cell Projection Extracellular Exosome
	Molecular Function	Protein Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Phospholipid Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Endocytosis Protein Transport	Protein Targeting To Membrane Intracellular Protein Transport Determination Of Left/right Symmetry Brain Development Visual Perception Regulation Of Smoothened Signaling Pathway Retina Layer Formation Protein Transport Wnt Signaling Pathway Vesicle-mediated Transport Cell Projection Organization Melanosome Transport Fat Cell Differentiation Protein Polymerization Cilium Assembly Protein Localization To Cilium Protein Localization To Non-motile Cilium Protein Transport From Ciliary Membrane To Plasma Membrane
Pathways			BBSome-mediated cargo-targeting to cilium
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Diseases			Bardet-Biedl syndrome (BBS) Retinitis pigmentosa (RP)
GWAS		Lymphocyte count ( 32888494) Ovarian cancer ( 23535730) Response to angiotensin II receptor blocker therapy ( 22566498)	Male infertility ( 19478329)
Interacting Genes		9 interacting genes: AP1G1 AP1G2 APPBP2 ARL6 CCDC91 GGA1 GGA2 GGA3 SCAMP1	12 interacting genes: ARL13B ARL6IP1 ARL6IP4 ARL6IP5 ARL6IP6 ATL2 CEBPD CRYBG3 GLS PROS1 SEC61B SYNRG
Entrez ID		11276	84100
HPRD ID		06291	10588
Ensembl ID		ENSG00000275066	ENSG00000113966
Uniprot IDs		Q9UMZ2	Q9H0F7
PDB IDs		2MX7	2H57
Enriched GO Terms of Interacting Partners?		Post-Golgi Vesicle-mediated Transport Golgi Vesicle Transport Protein Transport Establishment Of Protein Localization Trans-Golgi Network Establishment Of Localization In Cell Intracellular Protein Transport Intracellular Protein Localization Vesicle-mediated Transport Intracellular Transport Establishment Of Protein Localization To Plasma Membrane Cellular Localization Golgi To Vacuole Transport Membrane Coat Protein Localization To Cell Surface Golgi Apparatus Golgi To Plasma Membrane Protein Transport Vacuolar Transport Cytoplasmic Vesicle Membrane Protein Localization To Plasma Membrane Establishment Of Protein Localization To Membrane Protein Localization To Cell Periphery Golgi To Plasma Membrane Transport Clathrin-coated Vesicle Small GTPase Binding Endosome Membrane Protein Localization To Membrane Golgi To Lysosome Transport AP-1 Adaptor Complex Ubiquitin Binding Endosome Phosphatidylinositol Binding Lysosomal Transport Cytosolic Transport Clathrin Adaptor Activity Vesicle-mediated Transport To The Plasma Membrane Intracellular Vesicle Localization Within Membrane Early Endosome Membrane Membrane Protein Localization To Cilium Early Endosome Synaptic Vesicle Budding From Endosome Recycling Endosome Membrane Trans-Golgi Network Membrane Protein Transport From Ciliary Membrane To Plasma Membrane Recycling Endosome Basolateral Protein Secretion Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Lysosomal Protein Catabolic Process	Regulation Of L-glutamate Import Across Plasma Membrane Sec61 Translocon Complex Endoplasmic Reticulum Tubular Network Membrane Organization Endoplasmic Reticulum Membrane Organization Endoplasmic Reticulum Tubular Network Organization Cellular Localization Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sec Complex Endoplasmic Reticulum Organization Negative Regulation Of L-glutamate Import Across Plasma Membrane Regulation Of Amine Transport
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