IFT43 and NEK9

		IFT43	NEK9
Description		intraflagellar transport 43	NIMA related kinase 9
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GO Annotations	Cellular Component	Cytoplasm Centriole Cytoskeleton Cilium Microtubule Cytoskeleton Intraciliary Transport Particle A Centriolar Satellite Ciliary Basal Body Cell Projection Intercellular Bridge Mitotic Spindle Ciliary Tip	Nucleus Cytoplasm Centrosome Cytosol
	Molecular Function	Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Kinase Activator Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Cell Projection Organization Intraciliary Retrograde Transport Cilium Assembly	Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Cell Division Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Pathways		Intraflagellar transport	Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation
Drugs			Fostamatinib
Diseases
GWAS		Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Carpal tunnel syndrome ( 30833571) Emotional lability in attention deficit hyperactivity disorder ( 31085060)	Coronary artery disease ( 29212778) Feeling fed-up ( 29500382)
Interacting Genes		3 interacting genes: LMO2 NEK9 ZMYND10	25 interacting genes: BICD2 CSN2 GABARAP GZMB IFT43 JDP2 LIN52 MALL MAP1LC3A MAP1LC3B MBP NEK6 NEK7 NEK8 PALS1 PELI2 RAN RARG RPS6KL1 SSRP1 SUPT16H TTN UBC WDR33 WEE2-AS1
Entrez ID		112752	91754
HPRD ID		14449	11386
Ensembl ID		ENSG00000119650	ENSG00000119638
Uniprot IDs		Q96FT9	A0A7I2V454 A0A7I2V5R1 Q6PKF2 Q8TD19
PDB IDs		8BBE 8BBG 8FGW	3ZKE 3ZKF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Motile Cilium Assembly	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Protein-containing Complex Disassembly FACT Complex Organelle Assembly Autophagosome Maturation Ubiquitin Protein Ligase Binding Autophagosome Membrane Mitophagy Structural Constituent Of Myelin Sheath Microtubule Protein Serine Kinase Activity Autophagy Of Mitochondrion Autophagosome Protein Serine/threonine Kinase Activity Cellular Component Assembly Autophagosome Assembly Nucleosome Disassembly Microtubule Cytoskeleton Organization Protein-DNA Complex Disassembly Autophagosome Organization Endomembrane System Protein-containing Complex Organization Protein Kinase Activity Phospholipid Binding Cytoskeleton Microtubule-based Process Nucleosome Binding Positive Regulation Of Metalloendopeptidase Activity Protein Localization To Myelin Sheath Abaxonal Region DRM Complex Macroautophagy Spindle Organization Kinase Activity Pyroptotic Inflammatory Response Organelle Membrane Vacuole Organization
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