EGLN3 and FOXJ2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		EGLN3	FOXJ2
Description		egl-9 family hypoxia inducible factor 3	forkhead box J2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Chromatin Fibrillar Center Nucleus Nucleoplasm
	Molecular Function	Iron Ion Binding Protein Binding Ferrous Iron Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen 2-oxoglutarate-dependent Dioxygenase Activity L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity Metal Ion Binding Dioxygenase Activity Hypoxia-inducible Factor-proline Dioxygenase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Apoptotic Process DNA Damage Response Protein Hydroxylation Regulation Of Neuron Apoptotic Process Cellular Response To Hypoxia	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Male Meiosis I Spermatogenesis Negative Regulation Of Angiogenesis Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Meiotic Cell Cycle Negative Regulation Of Blood Vessel Endothelial Cell Differentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	Positive Regulation of CDH1 Gene Transcription
Drugs		Ascorbic acid Roxadustat Daprodustat Vadadustat
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Daytime sleep phenotypes ( 27126917) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Iron status biomarkers (ferritin levels) ( 33536631) Red blood cell count ( 32888494)	Granulocyte percentage of myeloid white cells ( 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		41 interacting genes: ABI2 ADRB2 ATF4 CDC20 CFTR CTBP2 DUSP7 EFHC2 EPAS1 EPOR FAM168B FOXJ2 GSC2 HIF1A HIF3A IK IKBKG IKZF3 LDB2 LNX1 MAPK1 MAPK7 MDM2 NCAPH2 NTAQ1 OS9 PKM PLEKHA2 PRPF19 RBBP8NL SERTAD1 SIAH2 SRP54 SUMO1 SUMO2 SUMO3 TP53 TTC23L WDR83 ZC2HC1A ZNF655	3 interacting genes: APP CSTF2T EGLN3
Entrez ID		112399	55810
HPRD ID		06972	17014
Ensembl ID		ENSG00000129521	ENSG00000065970
Uniprot IDs		B3KVT0 F8W1G2 Q3T1B0 Q9H6Z9	Q9P0K8
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Nuclear Speck Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Protein Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Intracellular Oxygen Homeostasis Cellular Response To Oxygen Levels Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Hypoxia Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Sumoylation PML Body Protein Tag Activity Regulation Of Nucleobase-containing Compound Metabolic Process Response To Decreased Oxygen Levels Positive Regulation Of RNA Metabolic Process Cellular Response To Stress Response To Oxygen Levels Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Response To Actinomycin D Transcription Regulator Complex Cytoplasm Protein Modification By Small Protein Conjugation Positive Regulation Of Macromolecule Metabolic Process Identical Protein Binding Response To Actinomycin D Ubiquitin-like Protein Ligase Binding Regulation Of Apoptotic Signaling Pathway Enzyme Binding Embryonic Organ Development Intracellular Signal Transduction Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Binding Cellular Response To UV-C Regulation Of Primary Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Biosynthetic Process Protein Modification Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Regulation Of Neuron Apoptotic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Hypoxia-inducible Factor-proline Dioxygenase Activity Peptidyl-proline 4-dioxygenase Activity Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel High-density Lipoprotein Particle
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