WDR6 and SCAP

		WDR6	SCAP
Description		WD repeat domain 6	SREBF chaperone
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane COP9 Signalosome	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus ER To Golgi Transport Vesicle Membrane Membrane Cytoplasmic Vesicle SREBP-SCAP Complex Protein-containing Complex
	Molecular Function	TRNA Binding RNA Binding Protein Binding Enzyme Regulator Activity	Protein Binding Lipid Binding Sterol Binding Protein-containing Complex Binding Unfolded Protein Binding
	Biological Process	Wobble Position Ribose Methylation TRNA Processing Negative Regulation Of Cell Population Proliferation Negative Regulation Of Autophagy TRNA Methylation G1 To G0 Transition	Response To Hypoxia Lipid Metabolic Process Immune Response Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Fatty Acid Metabolic Process Response To Insulin SREBP Signaling Pathway Response To Vitamin B3 Regulation Of Fatty Acid Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process COPII-coated Vesicle Cargo Loading
Pathways		RHOU GTPase cycle RHOV GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle	Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF)
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Menarche (age at onset) ( 25231870) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		7 interacting genes: BRCA1 CDC42EP4 G2E3 GRIP1 PTPN3 SCAP UBC	12 interacting genes: ATG16L1 DHX30 HIPK2 INSIG1 INSIG2 KLHL18 LAMC2 NDUFAF3 PGRMC1 SEC24B SREBF2 WDR6
Entrez ID		11180	22937
HPRD ID		06912	03300
Ensembl ID		ENSG00000178252	ENSG00000114650
Uniprot IDs		A0A087X295 B3KRR8 B4E256 E9PDU5 Q9H9M3 Q9NNW5	B7Z6H0 Q12770
PDB IDs			6M49 7ETW
Enriched GO Terms of Interacting Partners?		Regulation Of Fatty Acid Biosynthetic Process Histone H2AK127 Ubiquitin Ligase Activity Negative Regulation Of Lipid Biosynthetic Process Histone H2AK129 Ubiquitin Ligase Activity Intracellular Signal Transduction Negative Regulation Of Lipid Metabolic Process BRCA1-BARD1 Complex Regulation Of Fatty Acid Metabolic Process Response To Vitamin B3 SREBP-SCAP Complex Negative Regulation Of Small Molecule Metabolic Process Negative Regulation Of Centrosome Duplication Negative Regulation Of Centriole Replication BRCA1-A Complex XY Body BRCA1-B Complex Post-translational Protein Modification Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Lateral Element Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol Regulation Of Anatomical Structure Morphogenesis BRCA1-C Complex Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gamma-tubulin Ring Complex Ubiquitin-modified Histone Reader Activity Regulation Of Ketone Metabolic Process Response To Indole-3-methanol Negative Regulation Of Mitotic Cell Cycle Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation DNA Strand Resection Involved In Replication Fork Processing Ubiquitin-protein Transferase Activity Regulation Of Lipid Biosynthetic Process Protein Ubiquitination DNA Repair Complex Random Inactivation Of X Chromosome Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Membrane Depolarization During Action Potential Protein Tag Activity Sterol Binding Response To Sterol Depletion Negative Regulation Of Cholesterol Biosynthetic Process SREBP Signaling Pathway Negative Regulation Of Cholesterol Metabolic Process Cellular Response To Sterol Depletion Endomembrane System Endosome To Plasma Membrane Protein Transport Establishment Of Protein Localization To Postsynaptic Membrane Positive Regulation Of Neuron Projection Arborization	SREBP-SCAP-Insig Complex SREBP Signaling Pathway Cellular Response To Sterol Depletion Response To Sterol Depletion Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Cargo Loading Into COPII-coated Vesicle Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Biosynthetic Process ER-nucleus Signaling Pathway SREBP-SCAP Complex Retention In Endoplasmic Reticulum Positive Regulation Of Steroid Metabolic Process Negative Regulation Of SREBP Signaling Pathway Regulation Of Cholesterol Metabolic Process Cranial Suture Morphogenesis Regulation Of SREBP Signaling Pathway Regulation Of Steroid Biosynthetic Process Maintenance Of Protein Localization In Endoplasmic Reticulum Positive Regulation Of Lipid Biosynthetic Process Oxysterol Binding Regulation Of Steroid Metabolic Process Craniofacial Suture Morphogenesis Cholesterol Metabolic Process Sterol Metabolic Process Negative Regulation Of Fatty Acid Biosynthetic Process Middle Ear Morphogenesis Positive Regulation Of Lipid Metabolic Process NLS-bearing Protein Import Into Nucleus Negative Regulation Of Steroid Biosynthetic Process Embryonic Morphogenesis Positive Regulation Of Small Molecule Metabolic Process Lung Morphogenesis Negative Regulation Of Steroid Metabolic Process Cholesterol Biosynthetic Process Regulation Of Lipid Biosynthetic Process Negative Regulation Of Fatty Acid Metabolic Process Sterol Biosynthetic Process Maintenance Of Protein Localization In Organelle Protein Sequestering Activity Regulation Of Fatty Acid Biosynthetic Process Steroid Metabolic Process Negative Regulation Of Cargo Loading Into COPII-coated Vesicle Maintenance Of Protein Location In Cell Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Vacuole-isolation Membrane Contact Site ER To Golgi Transport Vesicle Membrane Inner Ear Morphogenesis Triglyceride Metabolic Process Alcohol Metabolic Process Maintenance Of Protein Location
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