ADAMTS6 and ARSB

		ADAMTS6	ARSB
Description		ADAM metallopeptidase with thrombospondin type 1 motif 6	arylsulfatase B
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix	Extracellular Region Lysosome Endoplasmic Reticulum Lumen Cell Surface Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding	N-acetylgalactosamine-4-sulfatase Activity Arylsulfatase Activity Sulfuric Ester Hydrolase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Kidney Development Cardiac Septum Development Proteolysis Heart Development Extracellular Matrix Organization Aorta Development Coronary Vasculature Development	Autophagy Lysosome Organization Lysosomal Transport Response To Nutrient Response To PH Regulation Of Epithelial Cell Migration Positive Regulation Of Neuron Projection Development Response To Estrogen Response To Methylmercury Colon Epithelial Cell Migration
Pathways		Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins	The activation of arylsulfatases CS/DS degradation MPS VI - Maroteaux-Lamy syndrome Neutrophil degranulation Glycosphingolipid catabolism
Drugs
Diseases			Mucopolysaccharidosis type VI (MPS6); Maroteaux-Lamy syndrome
GWAS		A body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159 31798171 29760442) Corneal structure ( 23291589) Corpus callosum anterior volume ( 31530798) Cortical surface area (MOSTest) ( 32665545) Feeling tense ( 29500382) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) Height ( 31562340) Inguinal hernia ( 26686553) Intraocular pressure ( 29617998 29785010 30054594) LDL levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Non-response to bupropion and depression ( 27622933) Osteosarcoma ( 23727862) Schizophrenia ( 23212062) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)	Attention deficit hyperactivity disorder ( 23728934) Birth weight ( 31043758) Blood and toenail selenium levels ( 25343990) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Depressive symptom improvement ( 30468137) Heel bone mineral density ( 30598549) Hippocampal atrophy ( 19668339) Iron status biomarkers ( 19084217) Macular thickness ( 30535121) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Non-word reading ( 30741946) Toenail selenium levels ( 25343990)
Interacting Genes		6 interacting genes: ARSB CD180 CDK7 ERCC8 PART1 SNTA1	2 interacting genes: ADAMTS6 FOXP2
Entrez ID		11174	411
HPRD ID		05421	08358
Ensembl ID		ENSG00000049192	ENSG00000113273
Uniprot IDs		Q5IR90 Q9UKP5	A8K4A0 P15848
PDB IDs			1FSU
Enriched GO Terms of Interacting Partners?		Colon Epithelial Cell Migration RNA Polymerase II CTD Heptapeptide Repeat S5 Kinase Activity Regulation Of Transcription-coupled Nucleotide-excision Repair N-acetylgalactosamine-4-sulfatase Activity Intestinal Epithelial Cell Migration	Putamen Development Caudate Nucleus Development Righting Reflex Vocal Learning Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Observational Learning Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Cerebellar Purkinje Cell Differentiation Auditory Behavior Mechanosensory Behavior Reflex Cell Differentiation In Hindbrain Vocalization Behavior Smooth Muscle Tissue Development Coronary Vasculature Development Positive Regulation Of Mesenchymal Cell Proliferation Aorta Development Regulation Of Mesenchymal Cell Proliferation Artery Development Cardiac Septum Development Transcription Coregulator Binding Lung Alveolus Development Cerebellum Development Animal Organ Development Neural Nucleus Development Skeletal Muscle Tissue Development Post-embryonic Development Cerebral Cortex Development Camera-type Eye Development Metalloendopeptidase Activity Lung Development
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