HHLA2 and BRICD5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HHLA2	BRICD5
Description		HHLA2 member of B7 family	BRICHOS domain containing 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	External Side Of Plasma Membrane Membrane	Extracellular Space Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding	Protein Binding
	Biological Process	Regulation Of Cytokine Production Positive Regulation Of Cytokine Production T Cell Costimulation Positive Regulation Of Activated T Cell Proliferation T Cell Receptor Signaling Pathway Regulation Of T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion	Regulation Of Cell Population Proliferation
Pathways
Drugs
Diseases
GWAS		Regular attendance at a religious group ( 29970889)	Appendicular lean mass ( 33097823)
Interacting Genes		14 interacting genes: AQP9 BRICD5 BTNL8 C3orf52 ERMP1 FAM3C NIPAL4 NRM PGA4 RPRM SMCO4 TMEM140 TNMD UNC93B1	39 interacting genes: AQP6 ARL13B BIK CD69 CD79A CLEC2D CLRN1 CREB3L1 FKBP7 HHLA2 HSD17B13 ICAM3 IFNGR2 IFNLR1 KIR2DL3 KLRC1 LMNA LRRC25 LRRC4C MRM1 MTIF3 MUC1 NEMP1 PLEKHO1 PSCA PVR SCN3B SGPL1 SIGLEC9 SLAMF6 SLC18A1 SLC18A2 SORT1 SYNE4 TMEM234 TMEM248 TMEM79 TMPRSS2 TMX2
Entrez ID		11148	283870
HPRD ID		05082	14482
Ensembl ID		ENSG00000114455	ENSG00000182685
Uniprot IDs		C9J7D0 Q9UM44	Q6PL45
PDB IDs
Enriched GO Terms of Interacting Partners?			Membrane Aminergic Neurotransmitter Loading Into Synaptic Vesicle Serotonin:sodium:chloride Symporter Activity Monoamine:proton Antiporter Activity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Clathrin-sculpted Monoamine Transport Vesicle Membrane Positive Regulation Of Natural Killer Cell Mediated Immunity Neurotransmitter Loading Into Synaptic Vesicle External Side Of Plasma Membrane Serotonin Uptake Monoamine Transmembrane Transporter Activity Plasma Membrane Type III Interferon-mediated Signaling Pathway Regulation Of Natural Killer Cell Mediated Cytotoxicity Amine Transport Regulation Of Natural Killer Cell Mediated Immunity Serotonin Transport Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Trans-Golgi Network Transport Vesicle Carbohydrate Binding Protein Binding Neurotransmitter Reuptake Dopamine Transport
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