IL1RAPL1 and ARHGAP22

Number of citations of the paper that reports this interaction (PubMedID 21926414)
36

Data Source:
BioGRID (pull down)

		IL1RAPL1	ARHGAP22
Description		interleukin 1 receptor accessory protein like 1	Rho GTPase activating protein 22
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Membrane Axon Dendrite Cell Projection Postsynaptic Membrane Glutamatergic Synapse	Nucleus Cytoplasm Cytosol Focal Adhesion Glutamatergic Synapse
	Molecular Function	Signaling Receptor Binding Protein Binding Hydrolase Activity Interleukin-1 Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating	GTPase Activator Activity Protein Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Neuron Projection Development Neuron Differentiation Negative Regulation Of Exocytosis Positive Regulation Of Synapse Assembly Positive Regulation Of Dendritic Spine Morphogenesis Presynaptic Membrane Assembly Regulation Of Postsynapse Organization Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion Regulation Of Presynapse Assembly	Angiogenesis Signal Transduction Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Postsynapse Organization
Pathways		Receptor-type tyrosine-protein phosphatases Interleukin-38 signaling	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases		Non-syndromic X-linked mental retardation
GWAS		Cardiovascular risk factors (age interaction) ( 20838585) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Vitiligo ( 27723757)	Conduct disorder ( 20585324) Daytime sleep phenotypes ( 27126917) Diabetic retinopathy ( 21310492) Femur bone mineral density x serum urate levels interaction ( 34046847) Macular thickness ( 30535121) Refractive error ( 32231278) Self-employment ( 23593239) Systolic blood pressure ( 31134134) Systolic blood pressure (education interaction) ( 31134134)
Interacting Genes		3 interacting genes: ARHGAP22 NCS1 POLA1	13 interacting genes: ALG11 CACNA1A CCNDBP1 CDC42 DEF6 FXR1 GPRIN2 IL1RAPL1 MAPK8 PTPN20 RAC1 RHOA ZNF488
Entrez ID		11141	58504
HPRD ID		02193	12476
Ensembl ID		ENSG00000169306	ENSG00000128805
Uniprot IDs		Q9NZN1 X5DNQ7	A0A2X0SFC0 Q7Z5H3
PDB IDs		1T3G 4M92 5WY8
Enriched GO Terms of Interacting Partners?		Mitotic DNA Replication Initiation Lagging Strand Elongation Alpha DNA Polymerase:primase Complex DNA Synthesis Involved In UV-damage Excision Repair Leading Strand Elongation Calcium Sensitive Guanylate Cyclase Activator Activity DNA Replication, Synthesis Of Primer DNA Strand Elongation Involved In DNA Replication DNA Polymerase Activity DNA Replication Origin Binding DNA Strand Elongation DNA-directed DNA Polymerase Activity DNA Replication Initiation Voltage-gated Calcium Channel Activity	Positive Regulation Of Stress Fiber Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Cell Projection G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Dendrite G Protein Activity Postsynapse Positive Regulation Of Cellular Component Biogenesis Thioesterase Binding Cytoplasmic Ribonucleoprotein Granule Glutamatergic Synapse Regulation Of Stress Fiber Assembly Regulation Of Synapse Organization Establishment Of Epithelial Cell Apical/basal Polarity GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Regulation Of Postsynapse Organization Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Rho Protein Signal Transduction Cerebral Cortex Cell Migration Establishment Of Epithelial Cell Polarity Establishment Or Maintenance Of Cell Polarity Regulation Of Protein-containing Complex Assembly Phagocytosis, Engulfment Regulation Of Cell Development Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cell Development Cell-cell Junction Organization Positive Regulation Of Lamellipodium Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Dendritic Spine Development Positive Regulation Of Protein-containing Complex Assembly Telencephalon Cell Migration Semaphorin-plexin Signaling Pathway Positive Regulation Of Cytokinesis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Substantia Nigra Development Substrate Adhesion-dependent Cell Spreading Regulation Of Cell-substrate Adhesion Forebrain Cell Migration Positive Regulation Of Neurogenesis Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity
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