CDC42EP1 and MAPKAP1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CDC42EP1	MAPKAP1
Description		CDC42 effector protein 1	MAPK associated protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Endomembrane System Membrane	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Cilium Membrane Early Endosome Membrane Late Endosome Membrane TORC2 Complex Perinuclear Region Of Cytoplasm Serine/threonine Protein Kinase Complex
	Molecular Function	Protein Binding Small GTPase Binding Cadherin Binding Involved In Cell-cell Adhesion	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Kinase Binding Small GTPase Binding Phosphatidylinositol-3,4-bisphosphate Binding Molecular Adaptor Activity Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding Enzyme-substrate Adaptor Activity
	Biological Process	Rho Protein Signal Transduction Regulation Of Cell Shape Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly Cell-cell Adhesion	Ubiquitin-dependent Protein Catabolic Process Cytoskeleton Organization Insulin Receptor Signaling Pathway Substantia Nigra Development Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels Cellular Response To Insulin Stimulus TORC2 Signaling Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Insulin Receptor Signaling Pathway Protein Stabilization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cellular Response To Oxidative Stress
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle	PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs
Diseases
GWAS			Body mass index ( 28892062) Diverticular disease ( 30177863) Fish- and plant-related diet ( 32066663) Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Medication use (calcium channel blockers) ( 31015401) Raw vegetable consumption ( 32066663) Resting heart rate ( 27798624) Sleep duration ( 30531941) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		14 interacting genes: AP1B1 ARMC7 CDC42 DEF6 FHL3 KRTAP4-12 MAPKAP1 MDFI OGT PLSCR1 PRKAA2 RBPMS RHOQ SAT1	12 interacting genes: ABCB1 AKT1 CDC42EP1 ECI1 MAPK8 MLST8 MTOR NRAS PRKCA SGK1 UBC YWHAG
Entrez ID		11135	79109
HPRD ID		07303	17464
Ensembl ID		ENSG00000128283	ENSG00000119487
Uniprot IDs		Q00587	Q9BPZ7
PDB IDs			3VOQ 5ZCS 6ZWM 6ZWO 7LC1 7LC2 7PE7 7PE8 7PE9 7TZO 7VV8 7VV9 7VVB 7VVG
Enriched GO Terms of Interacting Partners?		GBD Domain Binding TOR Signaling Organelle Organization Protein Kinase Binding Cytosol Filopodium Endothelin Receptor Signaling Pathway Involved In Heart Process Substantia Nigra Development Regulation Of Filopodium Assembly Neural Nucleus Development Positive Regulation Of Filopodium Assembly Intracellular Signal Transduction Storage Vacuole Phosphatidylserine Biosynthetic Process Mercury Ion Binding Lead Ion Binding Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Protein Localization To Lysosome Cellular Response To Glucose Stimulus Positive Regulation Of TOR Signaling Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Regulation Of Glycolytic Process Positive Regulation Of TORC1 Signaling Cellular Response To Carbohydrate Stimulus Negative Regulation Of Translational Initiation [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Histone H2BS36 Kinase Activity Intracellular Glucose Homeostasis Positive Regulation Of Translational Initiation Regulation Of Purine Nucleotide Metabolic Process Cellular Response To Nutrient Levels TORC1 Signaling Response To Hormone Cellular Response To Hormone Stimulus Diamine N-acetyltransferase Activity Spermidine Acetylation Putrescine Catabolic Process Spermidine Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Small GTPase Mediated Signal Transduction Phosphatidylinositol-3,4,5-trisphosphate Binding Response To Peptide Hormone Response To Insulin Regulation Of Insulin Receptor Signaling Pathway Protein O-acetylglucosaminyltransferase Activity Insulin Receptor Signaling Pathway Establishment Of Cell Polarity	Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation TORC1 Signaling TOR Signaling Intracellular Signal Transduction Positive Regulation Of TOR Signaling Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Nutrient Levels Positive Regulation Of Cellular Component Biogenesis Intracellular Signaling Cassette Cellular Response To Nutrient Levels Response To Peptide Hormone Response To Hormone Cellular Response To Hormone Stimulus Protein Serine Kinase Activity Regulation Of TOR Signaling Positive Regulation Of Pentose-phosphate Shunt Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein Serine/threonine Kinase Activity Cellular Response To Osmotic Stress Positive Regulation Of Actin Filament Polymerization Regulation Of Biological Quality Negative Regulation Of Translation Cellular Response To Starvation TORC1 Complex Regulation Of Pentose-phosphate Shunt SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein-containing Complex Assembly Cellular Response To Oxygen-containing Compound Negative Regulation Of TORC1 Signaling Response To Ketone Positive Regulation Of TORC1 Signaling Response To Starvation Regulation Of NADP Metabolic Process Protein Kinase Activity Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Response To Osmotic Stress TORC2 Complex Response To Alcohol Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Polymerization Cellular Response To Chemical Stress Cellular Response To Stress Anoikis Negative Regulation Of TOR Signaling Post-transcriptional Regulation Of Gene Expression Mitochondrion Positive Regulation Of Endothelial Cell Proliferation Regulation Of TORC2 Signaling
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