DNAJB4 and HSPA6

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		DNAJB4	HSPA6
Description		DnaJ heat shock protein family (Hsp40) member B4	heat shock protein family A (Hsp70) member 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Z Disc	Extracellular Region Nucleus Cytoplasm Centriole Cytosol Plasma Membrane COP9 Signalosome Secretory Granule Lumen Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	ATPase Activator Activity Protein Binding Unfolded Protein Binding Protein-folding Chaperone Binding	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Folding Response To Unfolded Protein Response To Heat	Protein Folding Response To Unfolded Protein Cellular Response To Heat Protein Refolding Cellular Heat Acclimation
Pathways			Regulation of HSF1-mediated heat shock response Neutrophil degranulation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cutaneous melanoma or hair colour ( 32341527) Diastolic blood pressure ( 30224653) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Waist circumference ( 25673412)	Alanine aminotransferase levels ( 33547301) Birth weight ( 31043758) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 23128233 28067908) Offspring birth weight ( 31043758) Ulcerative colitis ( 21297633 28067908)
Interacting Genes		11 interacting genes: HSPA1A HSPA6 MDM2 OPRM1 PABPN1 POLR1D RUVBL2 SDIM1 SMAD3 TBL1X TBPL2	20 interacting genes: ADCK5 AHCYL1 BAG4 C22orf15 CISH COMMD6 CYP4F12 DNAJB4 FCGR2B FLNA KRT222 LGALS7 LGALS7B MPZ PPIB PRAP1 RPA1 SNCA TERF1 WEE2-AS1
Entrez ID		11080	3310
HPRD ID		07486	00775
Ensembl ID		ENSG00000162616	ENSG00000173110
Uniprot IDs		B4DNN2 Q9UDY4	A0A384NKX5 B3KSM6 P17066
PDB IDs			3FE1
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Stability Protein Folding Cellular Heat Acclimation Protein Stabilization Unfolded Protein Binding Negative Regulation Of Cytosolic Calcium Ion Concentration Enzyme Binding Disordered Domain Specific Binding Protein Refolding Transcription Corepressor Activity ATP-dependent Protein Folding Chaperone COP9 Signalosome Regulation Of Cellular Response To Stress Cellular Response To Alkaloid Cellular Response To Heat Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Protein Folding Chaperone Heat Shock Protein Binding Regulation Of Canonical Wnt Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Lung Blood Pressure Positive Regulation Of Nucleocytoplasmic Transport Nuclear Mineralocorticoid Receptor Binding Regulation Of Nitric Oxide Metabolic Process Transcription Repressor Complex Response To Formaldehyde Cellular Response To Vitamin B1 Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Positive Regulation Of Polynucleotide Adenylyltransferase Activity Ubiquitin Protein Ligase Binding Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process ATP Hydrolysis Activity Denatured Protein Binding Negative Regulation Of RNA Metabolic Process Response To Unfolded Protein Response To Heat Regulation Of Protein Catabolic Process Negative Regulation Of Biosynthetic Process Response To Lipid Positive Regulation Of Transforming Growth Factor Beta3 Production Chromatin DNA Binding Positive Regulation Of Intracellular Protein Transport Response To Alkaloid Cellular Response To UV Nuclear DNA-directed RNA Polymerase Complex Ribonucleoprotein Complex	Regulation Of B Cell Antigen Processing And Presentation Negative Regulation Of Exocytosis Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Type I Hypersensitivity Negative Regulation Of Antibody-dependent Cellular Cytotoxicity Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Protein Stability Positive Regulation Of Organelle Organization Protein Sequestering Activity Intracellular Membrane-bounded Organelle Telomere Maintenance Via Telomere Lengthening RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomerase G-rich Strand Telomeric DNA Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of MRNA Modification Positive Regulation Of Triglyceride Transport Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Cellular Component Organization
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