CHD3 and FBP2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CHD3	FBP2
Description		chromodomain helicase DNA binding protein 3	fructose-bisphosphatase 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytoskeleton NuRD Complex PML Body Centriolar Satellite	Nucleus Cytoplasm Cytosol Plasma Membrane Z Disc Extracellular Exosome Anchoring Junction
	Molecular Function	Nucleotide Binding Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Histone Binding Metal Ion Binding ATP-dependent Chromatin Remodeler Activity	Catalytic Activity Protein Binding Hydrolase Activity Phosphatase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Phosphoric Ester Hydrolase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Spindle Organization Centrosome Cycle Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of Stem Cell Differentiation	Carbohydrate Metabolic Process Fructose Metabolic Process Fructose 6-phosphate Metabolic Process Gluconeogenesis Fructose 1,6-bisphosphate Metabolic Process
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	Gluconeogenesis
Drugs
Diseases
GWAS		Ischemic stroke ( 26089329) Macular thickness ( 30535121) Prostate cancer ( 29892016) Refractive error ( 32231278) Stroke ( 26089329)	Caudal middle frontal gyrus volume ( 31530798) Colorectal cancer (alcohol consumption interaction) ( 27723779) Height ( 19893584)
Interacting Genes		104 interacting genes: ACTR1B ADH5 AIMP2 ATP5IF1 BARD1 BCL6 BHLHE40 C4orf17 CASP6 CASP8 CBX4 CHMP2A CPE CRCT1 CREB1 CREBBP CSTF2 CTBP1 CTTN CUL2 ENTR1 ETV5 FABP4 FBP2 FUBP1 GADD45A GIT1 GPS2 GSK3B HABP4 HDAC2 HSD17B10 HSPH1 HTT IK IKZF1 IKZF3 IMMT IVNS1ABP KIF15 KPNA2 KPNB1 LRIF1 LUC7L2 MAFG MAN2A2 MX1 MYB NEFL NR1H2 NR4A1 PAICS PCMT1 PIAS1 PIAS4 PLK4 PRG2 PRPF40A PSME1 PTN PTPRS PUF60 RAD51 RETREG2 RGS2 RIF1 RNF10 RPL29 SAFB SAT1 SATB1 SERBP1 SERF2 SETX SGSM2 SIRT6 SKIL SLC27A6 SPOP SRRT STIP1 SUMO1 SUMO2 TAL1 TCERG1 THOC7 TNFRSF14 TNNT1 TP53 TP73 TRIM28 TRIM54 TSC22D1 TSPAN6 TTR TXNDC9 UBA3 UBC UBE2I UROD VIM XRCC4 YAE1 ZHX1	20 interacting genes: AURKA AXIN2 BMPR1A BUB1 CHD3 CTNNA1 DLC1 FBXW7 MAP2K4 MLH3 MSH2 NFRKB NRAS PDGFRL PIK3CA RB1 SMAD2 SMAD4 SRC STK11
Entrez ID		1107	8789
HPRD ID		09071	04322
Ensembl ID		ENSG00000170004	ENSG00000130957
Uniprot IDs		A0A8V8TR54 B3KWV4 Q12873 Q2TAZ1	O00757
PDB IDs			3IFA 3IFC 4HE0 4HE1 4HE2 5ET5 5ET6 5ET7 5ET8 5K54 5K55 5K56 5L0A 5Q0C
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Negative Regulation Of Transcription By RNA Polymerase II Identical Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process SUMO Transferase Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process PML Body Protein Sumoylation Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Cytoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Apoptotic Process Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Programmed Cell Death RNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Gene Expression Ubiquitin Protein Ligase Binding Regulation Of Cell Development Presynaptic Cytosol Postsynaptic Cytosol Enzyme Binding Positive Regulation Of Metabolic Process Nucleic Acid Metabolic Process Nuclear Speck Regulation Of Neurogenesis Macromolecule Metabolic Process DNA Repair Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gliogenesis Protein-containing Complex Regulation Of Proteolysis Positive Regulation Of Neuron Apoptotic Process Regulation Of Cellular Response To Stress Regulation Of Cell Differentiation Transcription Corepressor Activity Promoter-specific Chromatin Binding	Regulation Of Developmental Process Axis Specification Chromosome Organization Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Dorsal/ventral Axis Specification Heart Valve Morphogenesis I-SMAD Binding ATP Binding Intracellular Signal Transduction Animal Organ Morphogenesis Positive Regulation Of Cellular Component Organization Regulation Of Cell Development Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway Signal Transduction Kinase Activity Organelle Organization Regulation Of Organelle Organization Activin Responsive Factor Complex Odontogenesis Protein Serine/threonine Kinase Activity Regulation Of Cell Population Proliferation Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Developmental Process Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Nucleotide Binding Endoderm Development Regulation Of Chromosome Organization Reproductive Process Aortic Valve Morphogenesis Negative Regulation Of Metabolic Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Centromeric Sister Chromatid Cohesion Regulation Of Cell Cycle Anatomical Structure Morphogenesis Protein Kinase Activity Centromeric DNA Binding Regulation Of Multicellular Organismal Process Ubiquitin Protein Ligase Binding SMAD Binding Regulation Of Cellular Component Organization Response To Growth Factor Mesendoderm Development SMAD Protein Complex Maintenance Of DNA Repeat Elements Regulation Of Signal Transduction
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