ADAP1 and RANBP9

Number of citations of the paper that reports this interaction (PubMedID 18298663)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		ADAP1	RANBP9
Description		ArfGAP with dual PH domains 1	RAN binding protein 9
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane Membrane Nuclear Body
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Zinc Ion Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Metal Ion Binding Phosphatidylinositol Bisphosphate Binding	Protein Binding Enzyme Binding Small GTPase Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Regulation Of GTPase Activity	Cytoskeleton Organization Microtubule Nucleation Protein-containing Complex Assembly Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Pathways		Nuclear signaling by ERBB4	L1CAM interactions RAF/MAP kinase cascade MET activates RAS signaling Regulation of pyruvate metabolism
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Platelet distribution width ( 32888494)	Breast cancer ( 23535729 29059683)
Interacting Genes		25 interacting genes: ANP32A AP3B2 CSNK1A1 DNAAF5 DVL3 GADD45A GOLGA2 GSK3B NCL PIK3CA PLEKHF2 PRKCA PRKCE PRKCI PRKCZ PRKD1 PSME3 PURA RANBP9 RPS9 SDCBP2 SF3A3 SRSF2 SUB1 SUPV3L1	67 interacting genes: ADAP1 ADAP2 APC AR ATM AXL BACE1 BRCA1 BTG3 CACNA1G CALB1 CBR1 CBR3 CBS CCND1 CDK11B CDKN1A CFAP298 CLEC7A DDX4 DISC1 DYRK1B ENTPD1 ESR1 EXOC2 FMR1 GATD3 GID8 GRIK1 HIPK2 HMBS HNF4G ITGAL ITGB2 L1CAM LCOR LMNA MAPK6 MET MORC3 MPHOSPH8 NCOA6 NCOR2 NSRP1 PPARD PPARG PPP1CA PRKACA RAF1 RAN S100A7 SMAD2 SMAD3 SMAD9 SOD1 SOS1 SPOP SPP1 TFRC THRA THRB TP53 TP73 UCHL1 USP11 WNK1 ZBED1
Entrez ID		11033	10048
HPRD ID		09733	04835
Ensembl ID		ENSG00000105963	ENSG00000010017
Uniprot IDs		A0A087WTN6 A8K3A2 B4DUZ7 O75689	Q96S59
PDB IDs		3FEH 3FM8 3LJU 3MDB	5JI7 5JI9 5JIU 7NSC
Enriched GO Terms of Interacting Partners?		Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Phosphorylation Phosphorylation Insulin Receptor Substrate Binding Kinase Activity Intracellular Signal Transduction Protein Kinase Activity Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process PAR Polarity Complex Positive Regulation Of Protein Localization Positive Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Response To Peptide Hormone Positive Regulation Of Cellular Component Biogenesis ATP Binding Positive Regulation Of Cell Communication Regulation Of Signal Transduction Nucleus Positive Regulation Of Signaling Regulation Of Apoptotic Process Microtubule-based Process Cellular Response To Peptide Hormone Stimulus Cellular Response To Hormone Stimulus Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Cellular Component Organization Beta-catenin Destruction Complex Response To Phorbol 13-acetate 12-myristate Regulation Of Programmed Cell Death Positive Regulation Of Cell Projection Organization Regulation Of Metabolic Process Regulation Of Autophagy Negative Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Response To Hormone Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Localization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Ketone Positive Regulation Of Protein Localization To Membrane Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Developmental Process Cellular Developmental Process Animal Organ Development Regulation Of Programmed Cell Death Nucleoplasm Protein-containing Complex Binding Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Nuclear Receptor Activity Enzyme Binding Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Biological Quality Regulation Of Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Protein Kinase Binding Regulation Of MiRNA Transcription Regulation Of Gene Expression Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Molecular Condensate Scaffold Activity Cell Surface Receptor Signaling Pathway Transcription Coactivator Binding Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of MiRNA Transcription Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Response To Stress Nucleus Positive Regulation Of RNA Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Programmed Cell Death Ubiquitin Protein Ligase Binding Chromatin Binding Regulation Of Growth Apoptotic Signaling Pathway
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