CLP1 and PRR3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLP1	PRR3
Description		cleavage factor polyribonucleotide kinase subunit 1	proline rich 3
Image			No pdb structure
GO Annotations	Cellular Component	TRNA-intron Endonuclease Complex Nucleus Nucleoplasm Cytosol MRNA Cleavage Factor Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Kinase Activity Transferase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity Polynucleotide 5'-hydroxyl-kinase Activity ATP-dependent Polynucleotide 5'-hydroxyl-kinase Activity ATP-dependent Polyribonucleotide 5'-hydroxyl-kinase Activity	RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	TRNA Splicing, Via Endonucleolytic Cleavage And Ligation RNA Processing MRNA Processing TRNA Processing Cerebellar Cortex Development MRNA 3'-end Processing RISC Complex Assembly Global Gene Silencing By MRNA Cleavage
Pathways		tRNA processing in the nucleus mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Neuroticism ( 29255261) Schizophrenia ( 25056061 29483656)	Autism spectrum disorder or schizophrenia ( 28540026) Itch intensity from mosquito bite ( 28199695) Neuroticism ( 29255261)
Interacting Genes		16 interacting genes: APP CEP164 CPSF3 CREB3 DAGLB FGF16 FTO HCFC1 MEOX2 MESD NUDT21 PCMT1 PRR3 PSMB5 SNF8 YJU2B	25 interacting genes: APOBEC3C ASF1A BCL2L2-PABPN1 CCDC57 CLP1 DMRTB1 EXOSC8 HNRNPA0 KHDRBS2 KHDRBS3 KLF1 KRT31 KRTAP6-2 KRTAP6-3 MYPOP NXF1 PSMA3 RAMAC RBM3 RBMX RBMY1A1 RBMY1F RBMY1J SNRPA TLE5
Entrez ID		10978	80742
HPRD ID		16382	17915
Ensembl ID		ENSG00000172409	ENSG00000204576
Uniprot IDs		Q92989	B3KQA4 P79522 Q96QB9
PDB IDs		8HMY 8HMZ
Enriched GO Terms of Interacting Partners?		Release From Viral Latency Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway MRNA Cleavage And Polyadenylation Specificity Factor Complex Positive Regulation Of Monocyte Chemotaxis Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Chemotaxis Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Chemotaxis Amylin Binding Positive Regulation Of Toll Signaling Pathway Chromatin Binding Regulation Of Monocyte Chemotaxis Positive Regulation Of Deacetylase Activity MRNA 3'-end Processing Positive Regulation Of Pro-B Cell Differentiation RNA Repair TRNA Demethylase Activity	Regulation Of MRNA Splicing, Via Spliceosome MRNA Processing MRNA Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing RNA Processing Nucleic Acid Binding Positive Regulation Of RNA Splicing Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process RNA Binding RNA Metabolic Process Spliceosomal Complex Nucleic Acid Metabolic Process MRNA Binding Positive Regulation Of MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Splicing Nucleus Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Identical Protein Binding Regulation Of Gene Expression MRNA 3'-UTR AU-rich Region Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Gene Expression Intermediate Filament ATP-dependent Polyribonucleotide 5'-hydroxyl-kinase Activity Polynucleotide 5'-hydroxyl-kinase Activity ATP-dependent Polynucleotide 5'-hydroxyl-kinase Activity MRNA Capping Enzyme Complex MRNA Cap Methyltransferase RNMT:RAMAC Complex RNA 5'-cap (guanine-N7)-methylation Regulation Of Macromolecule Metabolic Process Global Gene Silencing By MRNA Cleavage U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Supraspliceosomal Complex Keratinization
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